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Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

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Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. / Johann, Kornelia; Cremer, Anna Lena; Fischer, Alexander W; Heine, Markus; Pensado, Eva Rial; Resch, Julia; Nock, Sebastian; Virtue, Samuel; Harder, Lisbeth; Oelkrug, Rebecca; Astiz, Mariana; Brabant, Georg; Warner, Amy; Vidal-Puig, Antonio; Oster, Henrik; Boelen, Anita; López, Miguel; Heeren, Joerg; Dalley, Jeffrey W; Backes, Heiko; Mittag, Jens.

In: CELL REP, Vol. 27, No. 11, 11.06.2019, p. 3385-3400.e3.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Johann, K, Cremer, AL, Fischer, AW, Heine, M, Pensado, ER, Resch, J, Nock, S, Virtue, S, Harder, L, Oelkrug, R, Astiz, M, Brabant, G, Warner, A, Vidal-Puig, A, Oster, H, Boelen, A, López, M, Heeren, J, Dalley, JW, Backes, H & Mittag, J 2019, 'Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption', CELL REP, vol. 27, no. 11, pp. 3385-3400.e3. https://doi.org/10.1016/j.celrep.2019.05.054

APA

Johann, K., Cremer, A. L., Fischer, A. W., Heine, M., Pensado, E. R., Resch, J., Nock, S., Virtue, S., Harder, L., Oelkrug, R., Astiz, M., Brabant, G., Warner, A., Vidal-Puig, A., Oster, H., Boelen, A., López, M., Heeren, J., Dalley, J. W., ... Mittag, J. (2019). Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. CELL REP, 27(11), 3385-3400.e3. https://doi.org/10.1016/j.celrep.2019.05.054

Vancouver

Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J et al. Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. CELL REP. 2019 Jun 11;27(11):3385-3400.e3. https://doi.org/10.1016/j.celrep.2019.05.054

Bibtex

@article{ae8084d650ac43f38db7a555e6935d30,
title = "Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption",
abstract = "Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and potentially providing metabolic benefits. Here, we show that browning by TH requires TH-receptor β and occurs independently of the sympathetic nervous system. The beige fat, however, lacks sufficient adrenergic stimulation and is not metabolically activated despite high levels of uncoupling protein 1 (UCP1). Studies at different environmental temperatures reveal that TH instead causes hyperthermia by actions in skeletal muscle combined with a central body temperature set-point elevation. Consequently, the metabolic and thermogenic effects of systemic hyperthyroidism were maintained in UCP1 knockout mice, demonstrating that neither beige nor brown fat contributes to the TH-induced hyperthermia and elevated glucose consumption, and underlining that the mere presence of UCP1 is insufficient to draw conclusions on the therapeutic potential of browning agents.",
keywords = "Adipose Tissue, Beige/metabolism, Adipose Tissue, Brown/metabolism, Adipose Tissue, White/metabolism, Animals, Glucose/metabolism, Male, Mice, Mice, Inbred C57BL, Muscle, Skeletal/metabolism, Receptors, Adrenergic, beta-3/metabolism, Thermogenesis, Thyroid Hormones/metabolism, Uncoupling Protein 1/genetics",
author = "Kornelia Johann and Cremer, {Anna Lena} and Fischer, {Alexander W} and Markus Heine and Pensado, {Eva Rial} and Julia Resch and Sebastian Nock and Samuel Virtue and Lisbeth Harder and Rebecca Oelkrug and Mariana Astiz and Georg Brabant and Amy Warner and Antonio Vidal-Puig and Henrik Oster and Anita Boelen and Miguel L{\'o}pez and Joerg Heeren and Dalley, {Jeffrey W} and Heiko Backes and Jens Mittag",
note = "Copyright {\textcopyright} 2019 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = jun,
day = "11",
doi = "10.1016/j.celrep.2019.05.054",
language = "English",
volume = "27",
pages = "3385--3400.e3",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

AU - Johann, Kornelia

AU - Cremer, Anna Lena

AU - Fischer, Alexander W

AU - Heine, Markus

AU - Pensado, Eva Rial

AU - Resch, Julia

AU - Nock, Sebastian

AU - Virtue, Samuel

AU - Harder, Lisbeth

AU - Oelkrug, Rebecca

AU - Astiz, Mariana

AU - Brabant, Georg

AU - Warner, Amy

AU - Vidal-Puig, Antonio

AU - Oster, Henrik

AU - Boelen, Anita

AU - López, Miguel

AU - Heeren, Joerg

AU - Dalley, Jeffrey W

AU - Backes, Heiko

AU - Mittag, Jens

N1 - Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2019/6/11

Y1 - 2019/6/11

N2 - Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and potentially providing metabolic benefits. Here, we show that browning by TH requires TH-receptor β and occurs independently of the sympathetic nervous system. The beige fat, however, lacks sufficient adrenergic stimulation and is not metabolically activated despite high levels of uncoupling protein 1 (UCP1). Studies at different environmental temperatures reveal that TH instead causes hyperthermia by actions in skeletal muscle combined with a central body temperature set-point elevation. Consequently, the metabolic and thermogenic effects of systemic hyperthyroidism were maintained in UCP1 knockout mice, demonstrating that neither beige nor brown fat contributes to the TH-induced hyperthermia and elevated glucose consumption, and underlining that the mere presence of UCP1 is insufficient to draw conclusions on the therapeutic potential of browning agents.

AB - Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and potentially providing metabolic benefits. Here, we show that browning by TH requires TH-receptor β and occurs independently of the sympathetic nervous system. The beige fat, however, lacks sufficient adrenergic stimulation and is not metabolically activated despite high levels of uncoupling protein 1 (UCP1). Studies at different environmental temperatures reveal that TH instead causes hyperthermia by actions in skeletal muscle combined with a central body temperature set-point elevation. Consequently, the metabolic and thermogenic effects of systemic hyperthyroidism were maintained in UCP1 knockout mice, demonstrating that neither beige nor brown fat contributes to the TH-induced hyperthermia and elevated glucose consumption, and underlining that the mere presence of UCP1 is insufficient to draw conclusions on the therapeutic potential of browning agents.

KW - Adipose Tissue, Beige/metabolism

KW - Adipose Tissue, Brown/metabolism

KW - Adipose Tissue, White/metabolism

KW - Animals

KW - Glucose/metabolism

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Muscle, Skeletal/metabolism

KW - Receptors, Adrenergic, beta-3/metabolism

KW - Thermogenesis

KW - Thyroid Hormones/metabolism

KW - Uncoupling Protein 1/genetics

U2 - 10.1016/j.celrep.2019.05.054

DO - 10.1016/j.celrep.2019.05.054

M3 - SCORING: Journal article

C2 - 31189119

VL - 27

SP - 3385-3400.e3

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 11

ER -