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Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice

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Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice. / Hidalgo, Yessia; Núñez, Sarah; Fuenzalida, Maria Jose; Flores-Santibáñez, Felipe; Sáez, Pablo J; Dorner, Jessica; Lennon-Dumenil, Ana-Maria; Martínez, Victor; Zorn, Emmanuel; Rosemblatt, Mario; Sauma, Daniela; Bono, Maria Rosa.

In: FRONT IMMUNOL, Vol. 11, 696, 2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hidalgo, Y, Núñez, S, Fuenzalida, MJ, Flores-Santibáñez, F, Sáez, PJ, Dorner, J, Lennon-Dumenil, A-M, Martínez, V, Zorn, E, Rosemblatt, M, Sauma, D & Bono, MR 2020, 'Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice', FRONT IMMUNOL, vol. 11, 696. https://doi.org/10.3389/fimmu.2020.00696

APA

Hidalgo, Y., Núñez, S., Fuenzalida, M. J., Flores-Santibáñez, F., Sáez, P. J., Dorner, J., Lennon-Dumenil, A-M., Martínez, V., Zorn, E., Rosemblatt, M., Sauma, D., & Bono, M. R. (2020). Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice. FRONT IMMUNOL, 11, [696]. https://doi.org/10.3389/fimmu.2020.00696

Vancouver

Hidalgo Y, Núñez S, Fuenzalida MJ, Flores-Santibáñez F, Sáez PJ, Dorner J et al. Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice. FRONT IMMUNOL. 2020;11. 696. https://doi.org/10.3389/fimmu.2020.00696

Bibtex

@article{122d15fed05e4b72b8b8c0289b736811,
title = "Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice",
abstract = "Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of autoreactive T and B cells, autoantibody production, and immune complex deposition in various organs. Previous evidence showed abnormal accumulation of B cells in the thymus of lupus-prone mice, but the role of this population in the progression of the disease remains mostly undefined. Here we analyzed the spatial distribution, function, and properties of this thymic B cell population in the BWF1 murine model of SLE. We found that in diseased animals, thymic B cells proliferate, and cluster in structures that resemble ectopic germinal centers. Moreover, we detected antibody-secreting cells in the thymus of diseased-BWF1 mice that produce anti-dsDNA IgG autoantibodies. We also found that thymic B cells from diseased-BWF1 mice induced the differentiation of thymocytes to follicular helper T cells (TFH). These data suggest that the accumulation of B cells in the thymus of BWF1 mice results in the formation of germinal center-like structures and the expansion of a TFH population, which may, in turn, activate and differentiate B cells into autoreactive plasma cells. Therefore, the thymus emerges as an important niche that supports the maintenance of the pathogenic humoral response in the development of murine SLE.",
author = "Yessia Hidalgo and Sarah N{\'u}{\~n}ez and Fuenzalida, {Maria Jose} and Felipe Flores-Santib{\'a}{\~n}ez and S{\'a}ez, {Pablo J} and Jessica Dorner and Ana-Maria Lennon-Dumenil and Victor Mart{\'i}nez and Emmanuel Zorn and Mario Rosemblatt and Daniela Sauma and Bono, {Maria Rosa}",
note = "Copyright {\textcopyright} 2020 Hidalgo, N{\'u}{\~n}ez, Fuenzalida, Flores-Santib{\'a}{\~n}ez, S{\'a}ez, Dorner, Lennon-Dumenil, Mart{\'i}nez, Zorn, Rosemblatt, Sauma and Bono.",
year = "2020",
doi = "10.3389/fimmu.2020.00696",
language = "English",
volume = "11",
journal = "FRONT IMMUNOL",
issn = "1664-3224",
publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice

AU - Hidalgo, Yessia

AU - Núñez, Sarah

AU - Fuenzalida, Maria Jose

AU - Flores-Santibáñez, Felipe

AU - Sáez, Pablo J

AU - Dorner, Jessica

AU - Lennon-Dumenil, Ana-Maria

AU - Martínez, Victor

AU - Zorn, Emmanuel

AU - Rosemblatt, Mario

AU - Sauma, Daniela

AU - Bono, Maria Rosa

N1 - Copyright © 2020 Hidalgo, Núñez, Fuenzalida, Flores-Santibáñez, Sáez, Dorner, Lennon-Dumenil, Martínez, Zorn, Rosemblatt, Sauma and Bono.

PY - 2020

Y1 - 2020

N2 - Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of autoreactive T and B cells, autoantibody production, and immune complex deposition in various organs. Previous evidence showed abnormal accumulation of B cells in the thymus of lupus-prone mice, but the role of this population in the progression of the disease remains mostly undefined. Here we analyzed the spatial distribution, function, and properties of this thymic B cell population in the BWF1 murine model of SLE. We found that in diseased animals, thymic B cells proliferate, and cluster in structures that resemble ectopic germinal centers. Moreover, we detected antibody-secreting cells in the thymus of diseased-BWF1 mice that produce anti-dsDNA IgG autoantibodies. We also found that thymic B cells from diseased-BWF1 mice induced the differentiation of thymocytes to follicular helper T cells (TFH). These data suggest that the accumulation of B cells in the thymus of BWF1 mice results in the formation of germinal center-like structures and the expansion of a TFH population, which may, in turn, activate and differentiate B cells into autoreactive plasma cells. Therefore, the thymus emerges as an important niche that supports the maintenance of the pathogenic humoral response in the development of murine SLE.

AB - Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of autoreactive T and B cells, autoantibody production, and immune complex deposition in various organs. Previous evidence showed abnormal accumulation of B cells in the thymus of lupus-prone mice, but the role of this population in the progression of the disease remains mostly undefined. Here we analyzed the spatial distribution, function, and properties of this thymic B cell population in the BWF1 murine model of SLE. We found that in diseased animals, thymic B cells proliferate, and cluster in structures that resemble ectopic germinal centers. Moreover, we detected antibody-secreting cells in the thymus of diseased-BWF1 mice that produce anti-dsDNA IgG autoantibodies. We also found that thymic B cells from diseased-BWF1 mice induced the differentiation of thymocytes to follicular helper T cells (TFH). These data suggest that the accumulation of B cells in the thymus of BWF1 mice results in the formation of germinal center-like structures and the expansion of a TFH population, which may, in turn, activate and differentiate B cells into autoreactive plasma cells. Therefore, the thymus emerges as an important niche that supports the maintenance of the pathogenic humoral response in the development of murine SLE.

U2 - 10.3389/fimmu.2020.00696

DO - 10.3389/fimmu.2020.00696

M3 - SCORING: Journal article

C2 - 32411134

VL - 11

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

M1 - 696

ER -