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Thy-1 (CD90) promotes bone formation and protects against obesity

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Thy-1 (CD90) promotes bone formation and protects against obesity. / Picke, Ann-Kristin; Campbell, Graeme M; Blüher, Matthias; Krügel, Ute; Schmidt, Felix N; Tsourdi, Elena; Winzer, Maria; Rauner, Martina; Vukicevic, Vladimir; Busse, Björn; Salbach-Hirsch, Juliane; Tuckermann, Jan P; Simon, Jan C; Anderegg, Ulf; Hofbauer, Lorenz C; Saalbach, Anja.

In: SCI TRANSL MED, Vol. 10, No. 453, 08.08.2018, p. eaao6806 .

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Picke, A-K, Campbell, GM, Blüher, M, Krügel, U, Schmidt, FN, Tsourdi, E, Winzer, M, Rauner, M, Vukicevic, V, Busse, B, Salbach-Hirsch, J, Tuckermann, JP, Simon, JC, Anderegg, U, Hofbauer, LC & Saalbach, A 2018, 'Thy-1 (CD90) promotes bone formation and protects against obesity', SCI TRANSL MED, vol. 10, no. 453, pp. eaao6806 . https://doi.org/10.1126/scitranslmed.aao6806

APA

Picke, A-K., Campbell, G. M., Blüher, M., Krügel, U., Schmidt, F. N., Tsourdi, E., Winzer, M., Rauner, M., Vukicevic, V., Busse, B., Salbach-Hirsch, J., Tuckermann, J. P., Simon, J. C., Anderegg, U., Hofbauer, L. C., & Saalbach, A. (2018). Thy-1 (CD90) promotes bone formation and protects against obesity. SCI TRANSL MED, 10(453), eaao6806 . https://doi.org/10.1126/scitranslmed.aao6806

Vancouver

Picke A-K, Campbell GM, Blüher M, Krügel U, Schmidt FN, Tsourdi E et al. Thy-1 (CD90) promotes bone formation and protects against obesity. SCI TRANSL MED. 2018 Aug 8;10(453):eaao6806 . https://doi.org/10.1126/scitranslmed.aao6806

Bibtex

@article{424010efe6d240f1b4db9831897495e2,
title = "Thy-1 (CD90) promotes bone formation and protects against obesity",
abstract = "Osteoporosis and obesity result from disturbed osteogenic and adipogenic differentiation and present emerging challenges for our aging society. Because of the regulatory role of Thy-1 in mesenchyme-derived fibroblasts, we investigated the impact of Thy-1 expression on mesenchymal stem cell (MSC) fate between osteogenic and adipogenic differentiation and consequences for bone formation and adipose tissue development in vivo. MSCs from Thy-1-deficient mice have decreased osteoblast differentiation and increased adipogenic differentiation compared to MSCs from wild-type mice. Consistently, Thy-1-deficient mice exhibited decreased bone volume and bone formation rate with elevated cortical porosity, resulting in lower bone strength. In parallel, body weight, subcutaneous/epigonadal fat mass, and bone fat volume were increased. Thy-1 deficiency was accompanied by reduced expression of specific Wnt ligands with simultaneous increase of the Wnt inhibitors sclerostin and dickkopf-1 and an altered responsiveness to Wnt. We demonstrated that disturbed bone remodeling in osteoporosis and dysregulated adipose tissue accumulation in patients with obesity were mirrored by reduced serum Thy-1 concentrations. Our findings provide new insights into the mutual regulation of bone formation and obesity and open new perspectives to monitor and to interfere with the dysregulated balance of adipogenesis and osteogenesis in obesity and osteoporosis.",
keywords = "Journal Article",
author = "Ann-Kristin Picke and Campbell, {Graeme M} and Matthias Bl{\"u}her and Ute Kr{\"u}gel and Schmidt, {Felix N} and Elena Tsourdi and Maria Winzer and Martina Rauner and Vladimir Vukicevic and Bj{\"o}rn Busse and Juliane Salbach-Hirsch and Tuckermann, {Jan P} and Simon, {Jan C} and Ulf Anderegg and Hofbauer, {Lorenz C} and Anja Saalbach",
note = "Copyright {\textcopyright} 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",
year = "2018",
month = aug,
day = "8",
doi = "10.1126/scitranslmed.aao6806",
language = "English",
volume = "10",
pages = "eaao6806 ",
journal = "SCI TRANSL MED",
issn = "1946-6234",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "453",

}

RIS

TY - JOUR

T1 - Thy-1 (CD90) promotes bone formation and protects against obesity

AU - Picke, Ann-Kristin

AU - Campbell, Graeme M

AU - Blüher, Matthias

AU - Krügel, Ute

AU - Schmidt, Felix N

AU - Tsourdi, Elena

AU - Winzer, Maria

AU - Rauner, Martina

AU - Vukicevic, Vladimir

AU - Busse, Björn

AU - Salbach-Hirsch, Juliane

AU - Tuckermann, Jan P

AU - Simon, Jan C

AU - Anderegg, Ulf

AU - Hofbauer, Lorenz C

AU - Saalbach, Anja

N1 - Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

PY - 2018/8/8

Y1 - 2018/8/8

N2 - Osteoporosis and obesity result from disturbed osteogenic and adipogenic differentiation and present emerging challenges for our aging society. Because of the regulatory role of Thy-1 in mesenchyme-derived fibroblasts, we investigated the impact of Thy-1 expression on mesenchymal stem cell (MSC) fate between osteogenic and adipogenic differentiation and consequences for bone formation and adipose tissue development in vivo. MSCs from Thy-1-deficient mice have decreased osteoblast differentiation and increased adipogenic differentiation compared to MSCs from wild-type mice. Consistently, Thy-1-deficient mice exhibited decreased bone volume and bone formation rate with elevated cortical porosity, resulting in lower bone strength. In parallel, body weight, subcutaneous/epigonadal fat mass, and bone fat volume were increased. Thy-1 deficiency was accompanied by reduced expression of specific Wnt ligands with simultaneous increase of the Wnt inhibitors sclerostin and dickkopf-1 and an altered responsiveness to Wnt. We demonstrated that disturbed bone remodeling in osteoporosis and dysregulated adipose tissue accumulation in patients with obesity were mirrored by reduced serum Thy-1 concentrations. Our findings provide new insights into the mutual regulation of bone formation and obesity and open new perspectives to monitor and to interfere with the dysregulated balance of adipogenesis and osteogenesis in obesity and osteoporosis.

AB - Osteoporosis and obesity result from disturbed osteogenic and adipogenic differentiation and present emerging challenges for our aging society. Because of the regulatory role of Thy-1 in mesenchyme-derived fibroblasts, we investigated the impact of Thy-1 expression on mesenchymal stem cell (MSC) fate between osteogenic and adipogenic differentiation and consequences for bone formation and adipose tissue development in vivo. MSCs from Thy-1-deficient mice have decreased osteoblast differentiation and increased adipogenic differentiation compared to MSCs from wild-type mice. Consistently, Thy-1-deficient mice exhibited decreased bone volume and bone formation rate with elevated cortical porosity, resulting in lower bone strength. In parallel, body weight, subcutaneous/epigonadal fat mass, and bone fat volume were increased. Thy-1 deficiency was accompanied by reduced expression of specific Wnt ligands with simultaneous increase of the Wnt inhibitors sclerostin and dickkopf-1 and an altered responsiveness to Wnt. We demonstrated that disturbed bone remodeling in osteoporosis and dysregulated adipose tissue accumulation in patients with obesity were mirrored by reduced serum Thy-1 concentrations. Our findings provide new insights into the mutual regulation of bone formation and obesity and open new perspectives to monitor and to interfere with the dysregulated balance of adipogenesis and osteogenesis in obesity and osteoporosis.

KW - Journal Article

U2 - 10.1126/scitranslmed.aao6806

DO - 10.1126/scitranslmed.aao6806

M3 - SCORING: Journal article

C2 - 30089635

VL - 10

SP - eaao6806

JO - SCI TRANSL MED

JF - SCI TRANSL MED

SN - 1946-6234

IS - 453

ER -