Thy-1 as a potential novel diagnostic marker for gastrointestinal stromal tumors.
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Thy-1 as a potential novel diagnostic marker for gastrointestinal stromal tumors. / Oikonomou, Despina; Hassan, Kambiz; Kaifi, Jussuf; Fiegel, Henning; Schurr, Paulus; Reichelt, Uta; Aridome, Kuniaki; Yekebas, Emre F.; Mann, Oliver; Kluth, Dietrich; Strate, Tim; Izbicki, Jakob R.
In: J CANCER RES CLIN, Vol. 133, No. 12, 12, 2007, p. 951-955.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Thy-1 as a potential novel diagnostic marker for gastrointestinal stromal tumors.
AU - Oikonomou, Despina
AU - Hassan, Kambiz
AU - Kaifi, Jussuf
AU - Fiegel, Henning
AU - Schurr, Paulus
AU - Reichelt, Uta
AU - Aridome, Kuniaki
AU - Yekebas, Emre F.
AU - Mann, Oliver
AU - Kluth, Dietrich
AU - Strate, Tim
AU - Izbicki, Jakob R.
PY - 2007
Y1 - 2007
N2 - PURPOSE: Only few immunohistochemical markers besides c-kit exist for gastrointestinal stromal tumors (GISTs). Thy-1, a cell-surface glycoprotein, is a marker for several types of stem cells and particularly for neuronal precursor cells. The aim of this study was to determine Thy-1 expression in GISTs. MATERIALS AND METHODS: Fifty-seven surgically resected and paraffin-embedded GIST samples were analyzed by immunohistochemistry with peroxidase method for Thy-1 molecule. RESULTS: Thy-1 was detected in the majority of 57 GIST samples (54 out of 57 patients, 95%). All samples were c-kit positive and 90% were CD34 positive. All three Thy-1 negative samples were CD34 positive, had a low proliferative index (Ki-67
AB - PURPOSE: Only few immunohistochemical markers besides c-kit exist for gastrointestinal stromal tumors (GISTs). Thy-1, a cell-surface glycoprotein, is a marker for several types of stem cells and particularly for neuronal precursor cells. The aim of this study was to determine Thy-1 expression in GISTs. MATERIALS AND METHODS: Fifty-seven surgically resected and paraffin-embedded GIST samples were analyzed by immunohistochemistry with peroxidase method for Thy-1 molecule. RESULTS: Thy-1 was detected in the majority of 57 GIST samples (54 out of 57 patients, 95%). All samples were c-kit positive and 90% were CD34 positive. All three Thy-1 negative samples were CD34 positive, had a low proliferative index (Ki-67
M3 - SCORING: Zeitschriftenaufsatz
VL - 133
SP - 951
EP - 955
JO - J CANCER RES CLIN
JF - J CANCER RES CLIN
SN - 0171-5216
IS - 12
M1 - 12
ER -