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THSD7A expression in human cancer

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THSD7A expression in human cancer. / Stahl, Phillip R; Hoxha, Elion; Wiech, Thorsten; Schröder, Cornelia; Simon, Ronald; Stahl, Rolf A K.

In: GENE CHROMOSOME CANC, Vol. 56, No. 4, 04.2017, p. 314-327.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stahl, PR, Hoxha, E, Wiech, T, Schröder, C, Simon, R & Stahl, RAK 2017, 'THSD7A expression in human cancer', GENE CHROMOSOME CANC, vol. 56, no. 4, pp. 314-327. https://doi.org/10.1002/gcc.22440

APA

Stahl, P. R., Hoxha, E., Wiech, T., Schröder, C., Simon, R., & Stahl, R. A. K. (2017). THSD7A expression in human cancer. GENE CHROMOSOME CANC, 56(4), 314-327. https://doi.org/10.1002/gcc.22440

Vancouver

Stahl PR, Hoxha E, Wiech T, Schröder C, Simon R, Stahl RAK. THSD7A expression in human cancer. GENE CHROMOSOME CANC. 2017 Apr;56(4):314-327. https://doi.org/10.1002/gcc.22440

Bibtex

@article{51b51c7122b54f2fa2db356bddc8b3b9,
title = "THSD7A expression in human cancer",
abstract = "We recently described a case of a Thrombospondin Type-1 Domain containing 7A (THSD7A) associated membranous nephropathy in a female patient who was synchronously suffering from a THSD7A-positive malignancy. We here investigated the role of THSD7A as a new potential tumor antigen by evaluating over 20 000 tissue spots in more than 70 different tumor entities by immunohistochemistry using tissue microarrays. THSD7A expression was highly variable in different neoplasias with differing staining patterns. Both gain and loss of THSD7A expression compared to expression status in non-tumor tissue were linked to tumor-specific markers in the different tumor entities and were of prognostic value. The potential role of THSD7A in tumor development and therapy needs further investigation.",
keywords = "Biomarkers, Tumor, Female, Humans, Immunoenzyme Techniques, Male, Neoplasm Grading, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Staging, Neoplasms, Prognosis, Survival Rate, Thrombospondins, Journal Article",
author = "Stahl, {Phillip R} and Elion Hoxha and Thorsten Wiech and Cornelia Schr{\"o}der and Ronald Simon and Stahl, {Rolf A K}",
note = "{\textcopyright} 2017 Wiley Periodicals, Inc.",
year = "2017",
month = apr,
doi = "10.1002/gcc.22440",
language = "English",
volume = "56",
pages = "314--327",
journal = "GENE CHROMOSOME CANC",
issn = "1045-2257",
publisher = "Wiley-Liss Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - THSD7A expression in human cancer

AU - Stahl, Phillip R

AU - Hoxha, Elion

AU - Wiech, Thorsten

AU - Schröder, Cornelia

AU - Simon, Ronald

AU - Stahl, Rolf A K

N1 - © 2017 Wiley Periodicals, Inc.

PY - 2017/4

Y1 - 2017/4

N2 - We recently described a case of a Thrombospondin Type-1 Domain containing 7A (THSD7A) associated membranous nephropathy in a female patient who was synchronously suffering from a THSD7A-positive malignancy. We here investigated the role of THSD7A as a new potential tumor antigen by evaluating over 20 000 tissue spots in more than 70 different tumor entities by immunohistochemistry using tissue microarrays. THSD7A expression was highly variable in different neoplasias with differing staining patterns. Both gain and loss of THSD7A expression compared to expression status in non-tumor tissue were linked to tumor-specific markers in the different tumor entities and were of prognostic value. The potential role of THSD7A in tumor development and therapy needs further investigation.

AB - We recently described a case of a Thrombospondin Type-1 Domain containing 7A (THSD7A) associated membranous nephropathy in a female patient who was synchronously suffering from a THSD7A-positive malignancy. We here investigated the role of THSD7A as a new potential tumor antigen by evaluating over 20 000 tissue spots in more than 70 different tumor entities by immunohistochemistry using tissue microarrays. THSD7A expression was highly variable in different neoplasias with differing staining patterns. Both gain and loss of THSD7A expression compared to expression status in non-tumor tissue were linked to tumor-specific markers in the different tumor entities and were of prognostic value. The potential role of THSD7A in tumor development and therapy needs further investigation.

KW - Biomarkers, Tumor

KW - Female

KW - Humans

KW - Immunoenzyme Techniques

KW - Male

KW - Neoplasm Grading

KW - Neoplasm Invasiveness

KW - Neoplasm Metastasis

KW - Neoplasm Staging

KW - Neoplasms

KW - Prognosis

KW - Survival Rate

KW - Thrombospondins

KW - Journal Article

U2 - 10.1002/gcc.22440

DO - 10.1002/gcc.22440

M3 - SCORING: Journal article

C2 - 28035718

VL - 56

SP - 314

EP - 327

JO - GENE CHROMOSOME CANC

JF - GENE CHROMOSOME CANC

SN - 1045-2257

IS - 4

ER -