Three-dimensional imaging of ventilation dynamics in asthmatics using multiecho projection acquisition with constrained reconstruction.
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Three-dimensional imaging of ventilation dynamics in asthmatics using multiecho projection acquisition with constrained reconstruction. / Holmes, James H; O'Halloran, Rafael L; Brodsky, Ethan K; Bley, Thorsten; Francois, Christopher J; Velikina, Julia V; Sorkness, Ronald L; Busse, William W; Fain, Sean B.
In: MAGN RESON MED, Vol. 62, No. 6, 6, 2009, p. 1543-1556.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Three-dimensional imaging of ventilation dynamics in asthmatics using multiecho projection acquisition with constrained reconstruction.
AU - Holmes, James H
AU - O'Halloran, Rafael L
AU - Brodsky, Ethan K
AU - Bley, Thorsten
AU - Francois, Christopher J
AU - Velikina, Julia V
AU - Sorkness, Ronald L
AU - Busse, William W
AU - Fain, Sean B
PY - 2009
Y1 - 2009
N2 - The purpose of this work is to detect dynamic gas trapping in three dimensions during forced exhalation at isotropic high spatial resolution and high temporal resolution using hyperpolarized helium-3 MRI. Ten subjects underwent hyperpolarized helium-3 MRI and multidetector CT. MRI was performed throughout inspiration, breath-hold, and forced expiration. A multiecho three-dimensional projection acquisition was used to improve data collection efficiency and an iterative constrained reconstruction was implemented to improve signal to noise ratio (SNR) and increase robustness to motion. Two radiologists evaluated the dynamic MRI and breath-held multidetector CT data for gas and air trapping, respectively. Phantom studies showed the proposed technique significantly improved depiction of moving objects compared to view-sharing methods. Gas trapping was detected using MRI in five of the six asthmatic subjects who displayed air trapping with multidetector CT. Locations in disagreement were found to represent small to moderate regions of air trapping. The proposed technique provides whole-lung three-dimensional imaging of respiration dynamics at high spatial and temporal resolution and compares well to the current standard, multidetector CT. While multidetector CT can provide information about static regional air trapping, it is unable to depict dynamics in a setting more comparable to a spirometry maneuver and explore the longitudinal time evolution of the trapped regions.
AB - The purpose of this work is to detect dynamic gas trapping in three dimensions during forced exhalation at isotropic high spatial resolution and high temporal resolution using hyperpolarized helium-3 MRI. Ten subjects underwent hyperpolarized helium-3 MRI and multidetector CT. MRI was performed throughout inspiration, breath-hold, and forced expiration. A multiecho three-dimensional projection acquisition was used to improve data collection efficiency and an iterative constrained reconstruction was implemented to improve signal to noise ratio (SNR) and increase robustness to motion. Two radiologists evaluated the dynamic MRI and breath-held multidetector CT data for gas and air trapping, respectively. Phantom studies showed the proposed technique significantly improved depiction of moving objects compared to view-sharing methods. Gas trapping was detected using MRI in five of the six asthmatic subjects who displayed air trapping with multidetector CT. Locations in disagreement were found to represent small to moderate regions of air trapping. The proposed technique provides whole-lung three-dimensional imaging of respiration dynamics at high spatial and temporal resolution and compares well to the current standard, multidetector CT. While multidetector CT can provide information about static regional air trapping, it is unable to depict dynamics in a setting more comparable to a spirometry maneuver and explore the longitudinal time evolution of the trapped regions.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Young Adult
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Algorithms
KW - Asthma diagnosis
KW - Contrast Media
KW - Echo-Planar Imaging methods
KW - Helium diagnostic use
KW - Image Enhancement methods
KW - Image Interpretation, Computer-Assisted methods
KW - Imaging, Three-Dimensional methods
KW - Isotopes diagnostic use
KW - Pulmonary Gas Exchange
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Young Adult
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Algorithms
KW - Asthma diagnosis
KW - Contrast Media
KW - Echo-Planar Imaging methods
KW - Helium diagnostic use
KW - Image Enhancement methods
KW - Image Interpretation, Computer-Assisted methods
KW - Imaging, Three-Dimensional methods
KW - Isotopes diagnostic use
KW - Pulmonary Gas Exchange
M3 - SCORING: Zeitschriftenaufsatz
VL - 62
SP - 1543
EP - 1556
JO - MAGN RESON MED
JF - MAGN RESON MED
SN - 0740-3194
IS - 6
M1 - 6
ER -
