Research ExplorerPublicationsThree Separate Spike Antigen Exposures by COVID-19 Vaccinati...

Three Separate Spike Antigen Exposures by COVID-19 Vaccination or SARS-CoV-2 Infection Elicit Strong Humoral Immune Responses in Healthcare Workers

Standard

Three Separate Spike Antigen Exposures by COVID-19 Vaccination or SARS-CoV-2 Infection Elicit Strong Humoral Immune Responses in Healthcare Workers. / Brehm, Thomas Theo; Ullrich, Felix; Thompson, Michelle; Küchen, Julia; Schwinge, Dorothee; Spier, Anthea; Huber, Samuel; Knobloch, Johannes K; Aepfelbacher, Martin; Addo, Marylyn M; Lohse, Ansgar W; Lütgehetmann, Marc; Schulze Zur Wiesch, Julian.

In: VACCINES-BASEL, Vol. 10, No. 7, 1086, 06.07.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Brehm, TT, Ullrich, F, Thompson, M, Küchen, J, Schwinge, D, Spier, A, Huber, S, Knobloch, JK, Aepfelbacher, M, Addo, MM, Lohse, AW, Lütgehetmann, M & Schulze Zur Wiesch, J 2022, 'Three Separate Spike Antigen Exposures by COVID-19 Vaccination or SARS-CoV-2 Infection Elicit Strong Humoral Immune Responses in Healthcare Workers', VACCINES-BASEL, vol. 10, no. 7, 1086. https://doi.org/10.3390/vaccines10071086

APA

Brehm, T. T., Ullrich, F., Thompson, M., Küchen, J., Schwinge, D., Spier, A., Huber, S., Knobloch, J. K., Aepfelbacher, M., Addo, M. M., Lohse, A. W., Lütgehetmann, M., & Schulze Zur Wiesch, J. (2022). Three Separate Spike Antigen Exposures by COVID-19 Vaccination or SARS-CoV-2 Infection Elicit Strong Humoral Immune Responses in Healthcare Workers. VACCINES-BASEL, 10(7), [1086]. https://doi.org/10.3390/vaccines10071086

Vancouver

Brehm TT, Ullrich F, Thompson M, Küchen J, Schwinge D, Spier A et al. Three Separate Spike Antigen Exposures by COVID-19 Vaccination or SARS-CoV-2 Infection Elicit Strong Humoral Immune Responses in Healthcare Workers. VACCINES-BASEL. 2022 Jul 6;10(7). 1086. https://doi.org/10.3390/vaccines10071086

Bibtex

@article{fd16012c616343f1a1c79819c18d00ca,
title = "Three Separate Spike Antigen Exposures by COVID-19 Vaccination or SARS-CoV-2 Infection Elicit Strong Humoral Immune Responses in Healthcare Workers",
abstract = "BACKGROUND: The immunogenicity of different COVID-19 vaccine regimens and combinations in na{\"i}ve and convalescent individuals has not been formally tested in controlled studies, and real-life observational studies are scarce.METHODS: We assessed the SARS-CoV-2 infection and COVID-19 vaccination-induced immunity of 697 hospital workers at the University Medical Center Hamburg-Eppendorf between 17 and 31 January 2022.RESULTS: The overall prevalence of anti-NC-SARS-CoV-2 antibodies indicating prior infection was 9.8% (n = 68) and thus lower than the seroprevalence in the general population. All vaccinated individuals had detectable anti-S1-RBD-SARS-CoV-2 antibodies (median AU/mL [IQR]: 13,891 [8505-23,543]), indicating strong protection against severe COVID-19. Individuals who received three COVID-19 vaccine doses (median AU/mL [IQR]: 13,856 [8635-22,705]) and those who resolved a prior SARS-CoV-2 infection and had received two COVID-19 vaccine doses (median AU/mL [IQR] 13,409 [6934-25,000]) exhibited the strongest humoral immune responses.CONCLUSIONS: The current study indicates that three exposures to the viral spike protein by either SARS-CoV-2 infection or COVID-19 vaccination are necessary to elicit particularly strong humoral immune responses, which supports current vaccination recommendations.",
author = "Brehm, {Thomas Theo} and Felix Ullrich and Michelle Thompson and Julia K{\"u}chen and Dorothee Schwinge and Anthea Spier and Samuel Huber and Knobloch, {Johannes K} and Martin Aepfelbacher and Addo, {Marylyn M} and Lohse, {Ansgar W} and Marc L{\"u}tgehetmann and {Schulze Zur Wiesch}, Julian",
year = "2022",
month = jul,
day = "6",
doi = "10.3390/vaccines10071086",
language = "English",
volume = "10",
journal = "VACCINES-BASEL",
issn = "2076-393X",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "7",

}

RIS

TY - JOUR

T1 - Three Separate Spike Antigen Exposures by COVID-19 Vaccination or SARS-CoV-2 Infection Elicit Strong Humoral Immune Responses in Healthcare Workers

AU - Brehm, Thomas Theo

AU - Ullrich, Felix

AU - Thompson, Michelle

AU - Küchen, Julia

AU - Schwinge, Dorothee

AU - Spier, Anthea

AU - Huber, Samuel

AU - Knobloch, Johannes K

AU - Aepfelbacher, Martin

AU - Addo, Marylyn M

AU - Lohse, Ansgar W

AU - Lütgehetmann, Marc

AU - Schulze Zur Wiesch, Julian

PY - 2022/7/6

Y1 - 2022/7/6

N2 - BACKGROUND: The immunogenicity of different COVID-19 vaccine regimens and combinations in naïve and convalescent individuals has not been formally tested in controlled studies, and real-life observational studies are scarce.METHODS: We assessed the SARS-CoV-2 infection and COVID-19 vaccination-induced immunity of 697 hospital workers at the University Medical Center Hamburg-Eppendorf between 17 and 31 January 2022.RESULTS: The overall prevalence of anti-NC-SARS-CoV-2 antibodies indicating prior infection was 9.8% (n = 68) and thus lower than the seroprevalence in the general population. All vaccinated individuals had detectable anti-S1-RBD-SARS-CoV-2 antibodies (median AU/mL [IQR]: 13,891 [8505-23,543]), indicating strong protection against severe COVID-19. Individuals who received three COVID-19 vaccine doses (median AU/mL [IQR]: 13,856 [8635-22,705]) and those who resolved a prior SARS-CoV-2 infection and had received two COVID-19 vaccine doses (median AU/mL [IQR] 13,409 [6934-25,000]) exhibited the strongest humoral immune responses.CONCLUSIONS: The current study indicates that three exposures to the viral spike protein by either SARS-CoV-2 infection or COVID-19 vaccination are necessary to elicit particularly strong humoral immune responses, which supports current vaccination recommendations.

AB - BACKGROUND: The immunogenicity of different COVID-19 vaccine regimens and combinations in naïve and convalescent individuals has not been formally tested in controlled studies, and real-life observational studies are scarce.METHODS: We assessed the SARS-CoV-2 infection and COVID-19 vaccination-induced immunity of 697 hospital workers at the University Medical Center Hamburg-Eppendorf between 17 and 31 January 2022.RESULTS: The overall prevalence of anti-NC-SARS-CoV-2 antibodies indicating prior infection was 9.8% (n = 68) and thus lower than the seroprevalence in the general population. All vaccinated individuals had detectable anti-S1-RBD-SARS-CoV-2 antibodies (median AU/mL [IQR]: 13,891 [8505-23,543]), indicating strong protection against severe COVID-19. Individuals who received three COVID-19 vaccine doses (median AU/mL [IQR]: 13,856 [8635-22,705]) and those who resolved a prior SARS-CoV-2 infection and had received two COVID-19 vaccine doses (median AU/mL [IQR] 13,409 [6934-25,000]) exhibited the strongest humoral immune responses.CONCLUSIONS: The current study indicates that three exposures to the viral spike protein by either SARS-CoV-2 infection or COVID-19 vaccination are necessary to elicit particularly strong humoral immune responses, which supports current vaccination recommendations.

U2 - 10.3390/vaccines10071086

DO - 10.3390/vaccines10071086

M3 - SCORING: Journal article

C2 - 35891249

VL - 10

JO - VACCINES-BASEL

JF - VACCINES-BASEL

SN - 2076-393X

IS - 7

M1 - 1086

ER -