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Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties

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Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties. / Shubina, Larisa K; Makarieva, Tatyana N; Dyshlovoy, Sergey A; Fedorov, Sergey N; Dmitrenok, Pavel S; Stonik, Valentin A.

In: NAT PROD COMMUN, Vol. 5, No. 12, 12.2010, p. 1881-4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Shubina, LK, Makarieva, TN, Dyshlovoy, SA, Fedorov, SN, Dmitrenok, PS & Stonik, VA 2010, 'Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties', NAT PROD COMMUN, vol. 5, no. 12, pp. 1881-4.

APA

Shubina, L. K., Makarieva, T. N., Dyshlovoy, S. A., Fedorov, S. N., Dmitrenok, P. S., & Stonik, V. A. (2010). Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties. NAT PROD COMMUN, 5(12), 1881-4.

Vancouver

Shubina LK, Makarieva TN, Dyshlovoy SA, Fedorov SN, Dmitrenok PS, Stonik VA. Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties. NAT PROD COMMUN. 2010 Dec;5(12):1881-4.

Bibtex

@article{194a6672474c46539fc3956a02962b29,
title = "Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties",
abstract = "Three new aaptamine-type alkaloids, 2,3-dihydro-2,3-dioxoaaptamine (1), 6-(N-morpholinyl)-4,5-dihydro-5-oxo-demethyl(oxy)aaptamine (2) and 3-(methylamino)demethyl(oxy)aaptamine (3), along with known aaptamines were isolated from the sponge Aaptos sp. Their structures were determined on the basis of detailed analysis of their 1D and 2D NMR spectroscopic and mass spectral data. The isolated compounds induced apoptosis in human leukemia THP-1 cells.",
keywords = "Alkaloids, Animals, Apoptosis, Cell Line, Humans, Magnetic Resonance Spectroscopy, Naphthyridines, Porifera, Journal Article, Research Support, Non-U.S. Gov't",
author = "Shubina, {Larisa K} and Makarieva, {Tatyana N} and Dyshlovoy, {Sergey A} and Fedorov, {Sergey N} and Dmitrenok, {Pavel S} and Stonik, {Valentin A}",
year = "2010",
month = dec,
language = "English",
volume = "5",
pages = "1881--4",
journal = "NAT PROD COMMUN",
issn = "1934-578X",
publisher = "Natural Product Communications",
number = "12",

}

RIS

TY - JOUR

T1 - Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties

AU - Shubina, Larisa K

AU - Makarieva, Tatyana N

AU - Dyshlovoy, Sergey A

AU - Fedorov, Sergey N

AU - Dmitrenok, Pavel S

AU - Stonik, Valentin A

PY - 2010/12

Y1 - 2010/12

N2 - Three new aaptamine-type alkaloids, 2,3-dihydro-2,3-dioxoaaptamine (1), 6-(N-morpholinyl)-4,5-dihydro-5-oxo-demethyl(oxy)aaptamine (2) and 3-(methylamino)demethyl(oxy)aaptamine (3), along with known aaptamines were isolated from the sponge Aaptos sp. Their structures were determined on the basis of detailed analysis of their 1D and 2D NMR spectroscopic and mass spectral data. The isolated compounds induced apoptosis in human leukemia THP-1 cells.

AB - Three new aaptamine-type alkaloids, 2,3-dihydro-2,3-dioxoaaptamine (1), 6-(N-morpholinyl)-4,5-dihydro-5-oxo-demethyl(oxy)aaptamine (2) and 3-(methylamino)demethyl(oxy)aaptamine (3), along with known aaptamines were isolated from the sponge Aaptos sp. Their structures were determined on the basis of detailed analysis of their 1D and 2D NMR spectroscopic and mass spectral data. The isolated compounds induced apoptosis in human leukemia THP-1 cells.

KW - Alkaloids

KW - Animals

KW - Apoptosis

KW - Cell Line

KW - Humans

KW - Magnetic Resonance Spectroscopy

KW - Naphthyridines

KW - Porifera

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 21299112

VL - 5

SP - 1881

EP - 1884

JO - NAT PROD COMMUN

JF - NAT PROD COMMUN

SN - 1934-578X

IS - 12

ER -