Think locally: control of ubiquitin-dependent protein degradation in neurons.
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Think locally: control of ubiquitin-dependent protein degradation in neurons. / Segref, Alexandra; Hoppe, Thorsten.
In: EMBO REP, Vol. 10, No. 1, 1, 2009, p. 44-50.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Think locally: control of ubiquitin-dependent protein degradation in neurons.
AU - Segref, Alexandra
AU - Hoppe, Thorsten
PY - 2009
Y1 - 2009
N2 - The nervous system coordinates many aspects of body function such as learning, memory, behaviour and locomotion. Therefore, it must develop and maintain an intricate network of differentiated neuronal cells, which communicate efficiently with each other and with non-neuronal target cells. Unlike most somatic cells, differentiated neurons are post-mitotic and characterized by a highly polarized morphology that determines the flow of information. Among other post-translational modifications, the ubiquitination of specific protein substrates was recently shown to have a crucial role in the regulation of neuronal development and differentiation. Here, we review recent findings that illustrate the mechanisms that mediate the temporal and spatial control of neuronal protein turnover by the ubiquitin-proteasome system (UPS), which is crucial for the development and function of the nervous system.
AB - The nervous system coordinates many aspects of body function such as learning, memory, behaviour and locomotion. Therefore, it must develop and maintain an intricate network of differentiated neuronal cells, which communicate efficiently with each other and with non-neuronal target cells. Unlike most somatic cells, differentiated neurons are post-mitotic and characterized by a highly polarized morphology that determines the flow of information. Among other post-translational modifications, the ubiquitination of specific protein substrates was recently shown to have a crucial role in the regulation of neuronal development and differentiation. Here, we review recent findings that illustrate the mechanisms that mediate the temporal and spatial control of neuronal protein turnover by the ubiquitin-proteasome system (UPS), which is crucial for the development and function of the nervous system.
M3 - SCORING: Zeitschriftenaufsatz
VL - 10
SP - 44
EP - 50
JO - EMBO REP
JF - EMBO REP
SN - 1469-221X
IS - 1
M1 - 1
ER -
