Therapy of gastric mucosa associated lymphoid tissue lymphoma
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Therapy of gastric mucosa associated lymphoid tissue lymphoma. / Morgner, Andrea; Schmelz, Renate; Thiede, Christian; Stolte, Manfred; Miehlke, Stephan.
In: WORLD J GASTROENTERO, Vol. 13, No. 26, 14.07.2007, p. 3554-66.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Therapy of gastric mucosa associated lymphoid tissue lymphoma
AU - Morgner, Andrea
AU - Schmelz, Renate
AU - Thiede, Christian
AU - Stolte, Manfred
AU - Miehlke, Stephan
PY - 2007/7/14
Y1 - 2007/7/14
N2 - Gastric mucosa associated lymphoid tissue (MALT) lymphoma has recently been incorporated into the World Health Organization (WHO) lymphoma classification, termed as extranodal marginal zone B-cell lymphoma of MALT-type. In about 90% of cases this lymphoma is associated with H pylori infection which has been clearly shown to play a causative role in lymphomagenesis. Although much knowledge has been gained in defining the clinical features, natural history, pathology, and molecular genetics of the disease in the last decade, the optimal treatment approach for gastric MALT lymphomas, especially locally advanced cases, is still evolving. In this review we focus on data for the therapeutic, stage dependent management of gastric MALT lymphoma. Hence, the role of eradication therapy, surgery, chemotherapy and radiotherapy is critically analyzed. Based on these data, we suggest a therapeutic algorithm that might help to better stratify patients for optimal treatment success.
AB - Gastric mucosa associated lymphoid tissue (MALT) lymphoma has recently been incorporated into the World Health Organization (WHO) lymphoma classification, termed as extranodal marginal zone B-cell lymphoma of MALT-type. In about 90% of cases this lymphoma is associated with H pylori infection which has been clearly shown to play a causative role in lymphomagenesis. Although much knowledge has been gained in defining the clinical features, natural history, pathology, and molecular genetics of the disease in the last decade, the optimal treatment approach for gastric MALT lymphomas, especially locally advanced cases, is still evolving. In this review we focus on data for the therapeutic, stage dependent management of gastric MALT lymphoma. Hence, the role of eradication therapy, surgery, chemotherapy and radiotherapy is critically analyzed. Based on these data, we suggest a therapeutic algorithm that might help to better stratify patients for optimal treatment success.
KW - Antibodies, Monoclonal
KW - Antibodies, Monoclonal, Murine-Derived
KW - Antineoplastic Agents
KW - Combined Modality Therapy
KW - Helicobacter Infections
KW - Helicobacter pylori
KW - Humans
KW - Lymphoma, B-Cell, Marginal Zone
KW - Neoplasm Staging
KW - Organoplatinum Compounds
KW - Radiotherapy
KW - Rituximab
KW - Stomach Neoplasms
KW - Journal Article
KW - Review
M3 - SCORING: Journal article
C2 - 17659705
VL - 13
SP - 3554
EP - 3566
JO - WORLD J GASTROENTERO
JF - WORLD J GASTROENTERO
SN - 1007-9327
IS - 26
ER -