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Therapeutisches Drug Monitoring von Antiinfektiva bei Intensivpatienten – für welche Arzneistoffe und wie?

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Therapeutisches Drug Monitoring von Antiinfektiva bei Intensivpatienten – für welche Arzneistoffe und wie? / König, Christina; Kluge, Stefan; Wicha, Sebastian G.

In: DEUT MED WOCHENSCHR, Vol. 145, No. 24, 12.2020, p. 1764-1769.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

König, C, Kluge, S & Wicha, SG 2020, 'Therapeutisches Drug Monitoring von Antiinfektiva bei Intensivpatienten – für welche Arzneistoffe und wie?', DEUT MED WOCHENSCHR, vol. 145, no. 24, pp. 1764-1769. https://doi.org/10.1055/a-1207-1914

APA

König, C., Kluge, S., & Wicha, S. G. (2020). Therapeutisches Drug Monitoring von Antiinfektiva bei Intensivpatienten – für welche Arzneistoffe und wie? DEUT MED WOCHENSCHR, 145(24), 1764-1769. https://doi.org/10.1055/a-1207-1914

Vancouver

König C, Kluge S, Wicha SG. Therapeutisches Drug Monitoring von Antiinfektiva bei Intensivpatienten – für welche Arzneistoffe und wie? DEUT MED WOCHENSCHR. 2020 Dec;145(24):1764-1769. https://doi.org/10.1055/a-1207-1914

Bibtex

@article{bf8807522a6d4722b429bb9180cdcb79,
title = "Therapeutisches Drug Monitoring von Antiinfektiva bei Intensivpatienten – f{\"u}r welche Arzneistoffe und wie?",
abstract = "Pharmacokinetic and pharmacodynamic changes in intensive care unit patients can increase the risk for therapeutic failure or adverse effects of anti-infective therapy. Therapeutic drug monitoring (TDM) can inform required dose adaptions. The present article reviews the current practice and outlines modern approaches for decision making such as model-informed precision dosing software using the area-under-the-concentration-time-curve as target in favor of simplistic decision making based on trough concentrations. Moreover, the current recommendations for performing TDM of beta-lactams, aminoglycosides, linezolid, glycopeptides and voriconazole are concisely summarized.",
keywords = "Anti-Infective Agents/administration & dosage, Clinical Decision-Making, Critical Care, Drug Monitoring, Humans, Intensive Care Units, Software",
author = "Christina K{\"o}nig and Stefan Kluge and Wicha, {Sebastian G}",
note = "Thieme. All rights reserved.",
year = "2020",
month = dec,
doi = "10.1055/a-1207-1914",
language = "Deutsch",
volume = "145",
pages = "1764--1769",
journal = "DEUT MED WOCHENSCHR",
issn = "0012-0472",
publisher = "Georg Thieme Verlag KG",
number = "24",

}

RIS

TY - JOUR

T1 - Therapeutisches Drug Monitoring von Antiinfektiva bei Intensivpatienten – für welche Arzneistoffe und wie?

AU - König, Christina

AU - Kluge, Stefan

AU - Wicha, Sebastian G

N1 - Thieme. All rights reserved.

PY - 2020/12

Y1 - 2020/12

N2 - Pharmacokinetic and pharmacodynamic changes in intensive care unit patients can increase the risk for therapeutic failure or adverse effects of anti-infective therapy. Therapeutic drug monitoring (TDM) can inform required dose adaptions. The present article reviews the current practice and outlines modern approaches for decision making such as model-informed precision dosing software using the area-under-the-concentration-time-curve as target in favor of simplistic decision making based on trough concentrations. Moreover, the current recommendations for performing TDM of beta-lactams, aminoglycosides, linezolid, glycopeptides and voriconazole are concisely summarized.

AB - Pharmacokinetic and pharmacodynamic changes in intensive care unit patients can increase the risk for therapeutic failure or adverse effects of anti-infective therapy. Therapeutic drug monitoring (TDM) can inform required dose adaptions. The present article reviews the current practice and outlines modern approaches for decision making such as model-informed precision dosing software using the area-under-the-concentration-time-curve as target in favor of simplistic decision making based on trough concentrations. Moreover, the current recommendations for performing TDM of beta-lactams, aminoglycosides, linezolid, glycopeptides and voriconazole are concisely summarized.

KW - Anti-Infective Agents/administration & dosage

KW - Clinical Decision-Making

KW - Critical Care

KW - Drug Monitoring

KW - Humans

KW - Intensive Care Units

KW - Software

U2 - 10.1055/a-1207-1914

DO - 10.1055/a-1207-1914

M3 - SCORING: Review

C2 - 33254251

VL - 145

SP - 1764

EP - 1769

JO - DEUT MED WOCHENSCHR

JF - DEUT MED WOCHENSCHR

SN - 0012-0472

IS - 24

ER -