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Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy

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Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy. / Zheng, Hanqiu; Bae, Yangjin; Kasimir-Bauer, Sabine; Tang, Rebecca; Chen, Jin; Ren, Guangwen; Yuan, Min; Esposito, Mark; Li, Wenyang; Wei, Yong; Shen, Minhong; Zhang, Lanjing; Tupitsyn, Nikolai; Pantel, Klaus; King, Chadwick; Sun, Jan; Moriguchi, Jodi; Jun, Helen Toni; Coxon, Angela; Lee, Brendan; Kang, Yibin.

In: CANCER CELL, Vol. 32, No. 6, 11.12.2017, p. 731-747.e6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zheng, H, Bae, Y, Kasimir-Bauer, S, Tang, R, Chen, J, Ren, G, Yuan, M, Esposito, M, Li, W, Wei, Y, Shen, M, Zhang, L, Tupitsyn, N, Pantel, K, King, C, Sun, J, Moriguchi, J, Jun, HT, Coxon, A, Lee, B & Kang, Y 2017, 'Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy', CANCER CELL, vol. 32, no. 6, pp. 731-747.e6. https://doi.org/10.1016/j.ccell.2017.11.002

APA

Zheng, H., Bae, Y., Kasimir-Bauer, S., Tang, R., Chen, J., Ren, G., Yuan, M., Esposito, M., Li, W., Wei, Y., Shen, M., Zhang, L., Tupitsyn, N., Pantel, K., King, C., Sun, J., Moriguchi, J., Jun, H. T., Coxon, A., ... Kang, Y. (2017). Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy. CANCER CELL, 32(6), 731-747.e6. https://doi.org/10.1016/j.ccell.2017.11.002

Vancouver

Zheng H, Bae Y, Kasimir-Bauer S, Tang R, Chen J, Ren G et al. Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy. CANCER CELL. 2017 Dec 11;32(6):731-747.e6. https://doi.org/10.1016/j.ccell.2017.11.002

Bibtex

@article{f5d365c0df6746b7bc9f53780fa3dd11,
title = "Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy",
abstract = "Bone metastasis is a major health threat to breast cancer patients. Tumor-derived Jagged1 represents a central node in mediating tumor-stromal interactions that promote osteolytic bone metastasis. Here, we report the development of a highly effective fully human monoclonal antibody against Jagged1 (clone 15D11). In addition to its inhibitory effect on bone metastasis of Jagged1-expressing tumor cells, 15D11 dramatically sensitizes bone metastasis to chemotherapy, which induces Jagged1 expression in osteoblasts to provide a survival niche for cancer cells. We further confirm the bone metastasis-promoting function of osteoblast-derived Jagged1 using osteoblast-specific Jagged1 transgenic mouse model. These findings establish 15D11 as a potential therapeutic agent for the prevention or treatment of bone metastasis.",
keywords = "Animals, Antibodies, Monoclonal, Antineoplastic Agents, Bone Neoplasms, Humans, Jagged-1 Protein, Mice, Mice, Transgenic, Osteoblasts, Xenograft Model Antitumor Assays, Journal Article",
author = "Hanqiu Zheng and Yangjin Bae and Sabine Kasimir-Bauer and Rebecca Tang and Jin Chen and Guangwen Ren and Min Yuan and Mark Esposito and Wenyang Li and Yong Wei and Minhong Shen and Lanjing Zhang and Nikolai Tupitsyn and Klaus Pantel and Chadwick King and Jan Sun and Jodi Moriguchi and Jun, {Helen Toni} and Angela Coxon and Brendan Lee and Yibin Kang",
note = "Copyright {\textcopyright} 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = dec,
day = "11",
doi = "10.1016/j.ccell.2017.11.002",
language = "English",
volume = "32",
pages = "731--747.e6",
journal = "CANCER CELL",
issn = "1535-6108",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy

AU - Zheng, Hanqiu

AU - Bae, Yangjin

AU - Kasimir-Bauer, Sabine

AU - Tang, Rebecca

AU - Chen, Jin

AU - Ren, Guangwen

AU - Yuan, Min

AU - Esposito, Mark

AU - Li, Wenyang

AU - Wei, Yong

AU - Shen, Minhong

AU - Zhang, Lanjing

AU - Tupitsyn, Nikolai

AU - Pantel, Klaus

AU - King, Chadwick

AU - Sun, Jan

AU - Moriguchi, Jodi

AU - Jun, Helen Toni

AU - Coxon, Angela

AU - Lee, Brendan

AU - Kang, Yibin

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/12/11

Y1 - 2017/12/11

N2 - Bone metastasis is a major health threat to breast cancer patients. Tumor-derived Jagged1 represents a central node in mediating tumor-stromal interactions that promote osteolytic bone metastasis. Here, we report the development of a highly effective fully human monoclonal antibody against Jagged1 (clone 15D11). In addition to its inhibitory effect on bone metastasis of Jagged1-expressing tumor cells, 15D11 dramatically sensitizes bone metastasis to chemotherapy, which induces Jagged1 expression in osteoblasts to provide a survival niche for cancer cells. We further confirm the bone metastasis-promoting function of osteoblast-derived Jagged1 using osteoblast-specific Jagged1 transgenic mouse model. These findings establish 15D11 as a potential therapeutic agent for the prevention or treatment of bone metastasis.

AB - Bone metastasis is a major health threat to breast cancer patients. Tumor-derived Jagged1 represents a central node in mediating tumor-stromal interactions that promote osteolytic bone metastasis. Here, we report the development of a highly effective fully human monoclonal antibody against Jagged1 (clone 15D11). In addition to its inhibitory effect on bone metastasis of Jagged1-expressing tumor cells, 15D11 dramatically sensitizes bone metastasis to chemotherapy, which induces Jagged1 expression in osteoblasts to provide a survival niche for cancer cells. We further confirm the bone metastasis-promoting function of osteoblast-derived Jagged1 using osteoblast-specific Jagged1 transgenic mouse model. These findings establish 15D11 as a potential therapeutic agent for the prevention or treatment of bone metastasis.

KW - Animals

KW - Antibodies, Monoclonal

KW - Antineoplastic Agents

KW - Bone Neoplasms

KW - Humans

KW - Jagged-1 Protein

KW - Mice

KW - Mice, Transgenic

KW - Osteoblasts

KW - Xenograft Model Antitumor Assays

KW - Journal Article

U2 - 10.1016/j.ccell.2017.11.002

DO - 10.1016/j.ccell.2017.11.002

M3 - SCORING: Journal article

C2 - 29232552

VL - 32

SP - 731-747.e6

JO - CANCER CELL

JF - CANCER CELL

SN - 1535-6108

IS - 6

ER -