The Ways of Tails: the GET Pathway and more
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The Ways of Tails: the GET Pathway and more : the GET Pathway and more. / Borgese, Nica; Coy-Vergara, Javier; Colombo, Sara Francesca; Schwappach, Blanche.
In: The protein journal, Vol. 38, No. 3, 06.2019, p. 289-305.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - The Ways of Tails: the GET Pathway and more
T2 - the GET Pathway and more
AU - Borgese, Nica
AU - Coy-Vergara, Javier
AU - Colombo, Sara Francesca
AU - Schwappach, Blanche
PY - 2019/6
Y1 - 2019/6
N2 - Due to their topology tail-anchored (TA) proteins must target to the membrane independently of the co-translational route defined by the signal sequence recognition particle (SRP), its receptor and the translocon Sec61. More than a decade of work has extensively characterized a highly conserved pathway, the yeast GET or mammalian TRC40 pathway, which is capable of countering the biogenetic challenge posed by the C-terminal TA anchor. In this review we briefly summarize current models of this targeting route and focus on emerging aspects such as the intricate interplay with the proteostatic network of cells and with other targeting pathways. Importantly, we consider the lessons provided by the in vivo analysis of the pathway in different model organisms and by the consideration of its full client spectrum in more recent studies. This analysis of the state of the field highlights directions in which the current models may be experimentally probed and conceptually extended.
AB - Due to their topology tail-anchored (TA) proteins must target to the membrane independently of the co-translational route defined by the signal sequence recognition particle (SRP), its receptor and the translocon Sec61. More than a decade of work has extensively characterized a highly conserved pathway, the yeast GET or mammalian TRC40 pathway, which is capable of countering the biogenetic challenge posed by the C-terminal TA anchor. In this review we briefly summarize current models of this targeting route and focus on emerging aspects such as the intricate interplay with the proteostatic network of cells and with other targeting pathways. Importantly, we consider the lessons provided by the in vivo analysis of the pathway in different model organisms and by the consideration of its full client spectrum in more recent studies. This analysis of the state of the field highlights directions in which the current models may be experimentally probed and conceptually extended.
KW - Animals
KW - Cell Membrane/metabolism
KW - Humans
KW - Membrane Proteins/chemistry
KW - Mice
KW - Protein Processing, Post-Translational
KW - Protein Transport
KW - Saccharomyces cerevisiae/metabolism
KW - Saccharomyces cerevisiae Proteins/metabolism
KW - Signal Recognition Particle/chemistry
U2 - 10.1007/s10930-019-09845-4
DO - 10.1007/s10930-019-09845-4
M3 - SCORING: Review article
C2 - 31203484
VL - 38
SP - 289
EP - 305
JO - PROTEIN J
JF - PROTEIN J
SN - 1572-3887
IS - 3
ER -