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The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease

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The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease. / Zengin, Elvin; Sinning, Christoph; Zeller, Tanja; Rupprecht, Hans-J; Schnabel, Renate B; Lackner, Karl-J; Blankenberg, Stefan; Westermann, Dirk; Bickel, Christoph; AtheroGene Investigators.

In: BIOMARK MED, Vol. 9, No. 8, 2015, p. 731-741.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zengin, E, Sinning, C, Zeller, T, Rupprecht, H-J, Schnabel, RB, Lackner, K-J, Blankenberg, S, Westermann, D, Bickel, C & AtheroGene Investigators 2015, 'The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease', BIOMARK MED, vol. 9, no. 8, pp. 731-741. https://doi.org/10.2217/BMM.15.41

APA

Zengin, E., Sinning, C., Zeller, T., Rupprecht, H-J., Schnabel, R. B., Lackner, K-J., Blankenberg, S., Westermann, D., Bickel, C., & AtheroGene Investigators (2015). The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease. BIOMARK MED, 9(8), 731-741. https://doi.org/10.2217/BMM.15.41

Vancouver

Zengin E, Sinning C, Zeller T, Rupprecht H-J, Schnabel RB, Lackner K-J et al. The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease. BIOMARK MED. 2015;9(8):731-741. https://doi.org/10.2217/BMM.15.41

Bibtex

@article{fce8979bc7ad4f37a285b5ef3d947ba3,
title = "The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease",
abstract = "BACKGROUND: Pregnancy-associated plasma protein-A (PAPP-A) is discussed as a biomarker representing unstable plaques in coronary artery disease (CAD).METHODS: In this study 927 patients with CAD (534 with stable angina and 393 with acute coronary syndrome [ACS]) and 217 patients without CAD and measured PAPP-A levels were included. Follow-up for a median of 5 years was documented.RESULTS: Rising quartiles of PAPP-A concentration had a higher cardiovascular mortality in the overall cohort of patients with CAD (p = 0.002) and the cohort with ACS (p = 0.01). Patients with suspected ACS below the LOD for troponin I but elevated PAPP-A levels had an increased cardiovascular mortality. A cut-off of 11.4 IU/l identified patients with a higher mortality during follow-up.CONCLUSION: Rising PAPP-A levels are prognostic in patients with CAD. PAPP-A levels were especially predictive in ACS patients with troponin below 10% CV of the 99 th percentile for cardiovascular mortality.",
keywords = "Aged, Biomarkers/blood, Cohort Studies, Coronary Artery Disease/blood, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Pregnancy-Associated Plasma Protein-A/metabolism, Prognosis, ROC Curve, Risk Factors, Troponin I/blood",
author = "Elvin Zengin and Christoph Sinning and Tanja Zeller and Hans-J Rupprecht and Schnabel, {Renate B} and Karl-J Lackner and Stefan Blankenberg and Dirk Westermann and Christoph Bickel and {AtheroGene Investigators}",
year = "2015",
doi = "10.2217/BMM.15.41",
language = "English",
volume = "9",
pages = "731--741",
journal = "BIOMARK MED",
issn = "1752-0363",
publisher = "Future Medicine Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease

AU - Zengin, Elvin

AU - Sinning, Christoph

AU - Zeller, Tanja

AU - Rupprecht, Hans-J

AU - Schnabel, Renate B

AU - Lackner, Karl-J

AU - Blankenberg, Stefan

AU - Westermann, Dirk

AU - Bickel, Christoph

AU - AtheroGene Investigators

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Pregnancy-associated plasma protein-A (PAPP-A) is discussed as a biomarker representing unstable plaques in coronary artery disease (CAD).METHODS: In this study 927 patients with CAD (534 with stable angina and 393 with acute coronary syndrome [ACS]) and 217 patients without CAD and measured PAPP-A levels were included. Follow-up for a median of 5 years was documented.RESULTS: Rising quartiles of PAPP-A concentration had a higher cardiovascular mortality in the overall cohort of patients with CAD (p = 0.002) and the cohort with ACS (p = 0.01). Patients with suspected ACS below the LOD for troponin I but elevated PAPP-A levels had an increased cardiovascular mortality. A cut-off of 11.4 IU/l identified patients with a higher mortality during follow-up.CONCLUSION: Rising PAPP-A levels are prognostic in patients with CAD. PAPP-A levels were especially predictive in ACS patients with troponin below 10% CV of the 99 th percentile for cardiovascular mortality.

AB - BACKGROUND: Pregnancy-associated plasma protein-A (PAPP-A) is discussed as a biomarker representing unstable plaques in coronary artery disease (CAD).METHODS: In this study 927 patients with CAD (534 with stable angina and 393 with acute coronary syndrome [ACS]) and 217 patients without CAD and measured PAPP-A levels were included. Follow-up for a median of 5 years was documented.RESULTS: Rising quartiles of PAPP-A concentration had a higher cardiovascular mortality in the overall cohort of patients with CAD (p = 0.002) and the cohort with ACS (p = 0.01). Patients with suspected ACS below the LOD for troponin I but elevated PAPP-A levels had an increased cardiovascular mortality. A cut-off of 11.4 IU/l identified patients with a higher mortality during follow-up.CONCLUSION: Rising PAPP-A levels are prognostic in patients with CAD. PAPP-A levels were especially predictive in ACS patients with troponin below 10% CV of the 99 th percentile for cardiovascular mortality.

KW - Aged

KW - Biomarkers/blood

KW - Cohort Studies

KW - Coronary Artery Disease/blood

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Pregnancy-Associated Plasma Protein-A/metabolism

KW - Prognosis

KW - ROC Curve

KW - Risk Factors

KW - Troponin I/blood

U2 - 10.2217/BMM.15.41

DO - 10.2217/BMM.15.41

M3 - SCORING: Journal article

C2 - 26223809

VL - 9

SP - 731

EP - 741

JO - BIOMARK MED

JF - BIOMARK MED

SN - 1752-0363

IS - 8

ER -