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The US7 score is sensitive to change in a large cohort of patients with rheumatoid arthritis over 12 months of therapy

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The US7 score is sensitive to change in a large cohort of patients with rheumatoid arthritis over 12 months of therapy. / Backhaus, Tina M; Ohrndorf, Sarah; Kellner, Herbert; Strunk, Johannes; Hartung, Wolfgang; Sattler, Horst; Iking-Konert, Christof; Burmester, Gerd R; Schmidt, Wolfgang A; Backhaus, Marina.

In: ANN RHEUM DIS, Vol. 72, No. 7, 01.07.2013, p. 1163-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Backhaus, TM, Ohrndorf, S, Kellner, H, Strunk, J, Hartung, W, Sattler, H, Iking-Konert, C, Burmester, GR, Schmidt, WA & Backhaus, M 2013, 'The US7 score is sensitive to change in a large cohort of patients with rheumatoid arthritis over 12 months of therapy', ANN RHEUM DIS, vol. 72, no. 7, pp. 1163-9. https://doi.org/10.1136/annrheumdis-2012-201397

APA

Backhaus, T. M., Ohrndorf, S., Kellner, H., Strunk, J., Hartung, W., Sattler, H., Iking-Konert, C., Burmester, G. R., Schmidt, W. A., & Backhaus, M. (2013). The US7 score is sensitive to change in a large cohort of patients with rheumatoid arthritis over 12 months of therapy. ANN RHEUM DIS, 72(7), 1163-9. https://doi.org/10.1136/annrheumdis-2012-201397

Vancouver

Backhaus TM, Ohrndorf S, Kellner H, Strunk J, Hartung W, Sattler H et al. The US7 score is sensitive to change in a large cohort of patients with rheumatoid arthritis over 12 months of therapy. ANN RHEUM DIS. 2013 Jul 1;72(7):1163-9. https://doi.org/10.1136/annrheumdis-2012-201397

Bibtex

@article{ef6ead075e1f489eb32595393c74a184,
title = "The US7 score is sensitive to change in a large cohort of patients with rheumatoid arthritis over 12 months of therapy",
abstract = "PURPOSE: To determine the sensitivity to change of the US7 score among RA patients under various therapies and to analyze the effect of each therapeutic option over 1 year. To estimate predictors for development of destructive bone changes.METHODS: Musculoskeletal ultrasound (US7 score), DAS28, CRP and ESR were performed in 432 RA patients at baseline and after 3, 6 and 12 months. The cohort was divided into four sub-groups: first-line DMARDs (Group 1; 27.3%), therapy switch: DMARDs to second DMARDs (Group 2; 25.0%), first-line biologic after DMARDs therapy (Group 3; 35.4%) and therapy change from biologic to second biologic (Group 4; 12.3%).RESULTS: The US7 synovitis and tenosynovitis sum scores in grey-scale (GSUS) and power Doppler ultrasound (PDUS) as well as ESR, CRP decreased significantly (p<0.05) after 12 months in group 1 to 3. Group 1+2 also illustrated a significant change of DAS28 after 1 year (p<0.001). Only in Group 4, the US7 erosion sum score decreased significantly from 4.3 to 3.6 (p=0.008) after 1 year. Predictors capable of forecasting US erosions after one year were: higher score of US7 synovitis (p<0.001), of US7 erosions in GSUS (p<0.001), as well as of DAS28 (p<0.001) at baseline.CONCLUSIONS: The comparable developments of the US7 score with clinical and laboratory data illustrates its potential to reflect therapeutic response. Therefore, the novel US7 score is sensitive to change. Patients who switched from one biologic to another exhibited a significant decline in erosions after 12 months, while the erosions scores in the other groups were stable.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Antirheumatic Agents, Arthritis, Rheumatoid, Cohort Studies, Female, Foot Joints, Hand Joints, Humans, Male, Middle Aged, Sensitivity and Specificity, Synovitis, Tenosynovitis, Treatment Outcome, Ultrasonography, Doppler, Color, Young Adult",
author = "Backhaus, {Tina M} and Sarah Ohrndorf and Herbert Kellner and Johannes Strunk and Wolfgang Hartung and Horst Sattler and Christof Iking-Konert and Burmester, {Gerd R} and Schmidt, {Wolfgang A} and Marina Backhaus",
year = "2013",
month = jul,
day = "1",
doi = "10.1136/annrheumdis-2012-201397",
language = "English",
volume = "72",
pages = "1163--9",
journal = "ANN RHEUM DIS",
issn = "0003-4967",
publisher = "BMJ PUBLISHING GROUP",
number = "7",

}

RIS

TY - JOUR

T1 - The US7 score is sensitive to change in a large cohort of patients with rheumatoid arthritis over 12 months of therapy

AU - Backhaus, Tina M

AU - Ohrndorf, Sarah

AU - Kellner, Herbert

AU - Strunk, Johannes

AU - Hartung, Wolfgang

AU - Sattler, Horst

AU - Iking-Konert, Christof

AU - Burmester, Gerd R

AU - Schmidt, Wolfgang A

AU - Backhaus, Marina

PY - 2013/7/1

Y1 - 2013/7/1

N2 - PURPOSE: To determine the sensitivity to change of the US7 score among RA patients under various therapies and to analyze the effect of each therapeutic option over 1 year. To estimate predictors for development of destructive bone changes.METHODS: Musculoskeletal ultrasound (US7 score), DAS28, CRP and ESR were performed in 432 RA patients at baseline and after 3, 6 and 12 months. The cohort was divided into four sub-groups: first-line DMARDs (Group 1; 27.3%), therapy switch: DMARDs to second DMARDs (Group 2; 25.0%), first-line biologic after DMARDs therapy (Group 3; 35.4%) and therapy change from biologic to second biologic (Group 4; 12.3%).RESULTS: The US7 synovitis and tenosynovitis sum scores in grey-scale (GSUS) and power Doppler ultrasound (PDUS) as well as ESR, CRP decreased significantly (p<0.05) after 12 months in group 1 to 3. Group 1+2 also illustrated a significant change of DAS28 after 1 year (p<0.001). Only in Group 4, the US7 erosion sum score decreased significantly from 4.3 to 3.6 (p=0.008) after 1 year. Predictors capable of forecasting US erosions after one year were: higher score of US7 synovitis (p<0.001), of US7 erosions in GSUS (p<0.001), as well as of DAS28 (p<0.001) at baseline.CONCLUSIONS: The comparable developments of the US7 score with clinical and laboratory data illustrates its potential to reflect therapeutic response. Therefore, the novel US7 score is sensitive to change. Patients who switched from one biologic to another exhibited a significant decline in erosions after 12 months, while the erosions scores in the other groups were stable.

AB - PURPOSE: To determine the sensitivity to change of the US7 score among RA patients under various therapies and to analyze the effect of each therapeutic option over 1 year. To estimate predictors for development of destructive bone changes.METHODS: Musculoskeletal ultrasound (US7 score), DAS28, CRP and ESR were performed in 432 RA patients at baseline and after 3, 6 and 12 months. The cohort was divided into four sub-groups: first-line DMARDs (Group 1; 27.3%), therapy switch: DMARDs to second DMARDs (Group 2; 25.0%), first-line biologic after DMARDs therapy (Group 3; 35.4%) and therapy change from biologic to second biologic (Group 4; 12.3%).RESULTS: The US7 synovitis and tenosynovitis sum scores in grey-scale (GSUS) and power Doppler ultrasound (PDUS) as well as ESR, CRP decreased significantly (p<0.05) after 12 months in group 1 to 3. Group 1+2 also illustrated a significant change of DAS28 after 1 year (p<0.001). Only in Group 4, the US7 erosion sum score decreased significantly from 4.3 to 3.6 (p=0.008) after 1 year. Predictors capable of forecasting US erosions after one year were: higher score of US7 synovitis (p<0.001), of US7 erosions in GSUS (p<0.001), as well as of DAS28 (p<0.001) at baseline.CONCLUSIONS: The comparable developments of the US7 score with clinical and laboratory data illustrates its potential to reflect therapeutic response. Therefore, the novel US7 score is sensitive to change. Patients who switched from one biologic to another exhibited a significant decline in erosions after 12 months, while the erosions scores in the other groups were stable.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antirheumatic Agents

KW - Arthritis, Rheumatoid

KW - Cohort Studies

KW - Female

KW - Foot Joints

KW - Hand Joints

KW - Humans

KW - Male

KW - Middle Aged

KW - Sensitivity and Specificity

KW - Synovitis

KW - Tenosynovitis

KW - Treatment Outcome

KW - Ultrasonography, Doppler, Color

KW - Young Adult

U2 - 10.1136/annrheumdis-2012-201397

DO - 10.1136/annrheumdis-2012-201397

M3 - SCORING: Journal article

C2 - 22956596

VL - 72

SP - 1163

EP - 1169

JO - ANN RHEUM DIS

JF - ANN RHEUM DIS

SN - 0003-4967

IS - 7

ER -