The translocations t(6;18;11)(q24;q21;q21) and t(11;14;18)(q21;q32;q21) lead to a fusion of the API2 and MALT1 genes and occur in MALT lymphomas.
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The translocations t(6;18;11)(q24;q21;q21) and t(11;14;18)(q21;q32;q21) lead to a fusion of the API2 and MALT1 genes and occur in MALT lymphomas. / Murga-Penas, Eva-Maria; Eva, M; Callet-Bauchu, Evelyne; Ye, Hongtao; Albert, Nadine; Albert, Nadine; Copie-Bergman, Christiane; Gazzo, Sophie; Berger, Françoise; Bokemeyer, Carsten; Bokemeyer, Carsten; Dierlamm, Judith; Dierlamm, Judith.
In: HAEMATOLOGICA, Vol. 92, No. 3, 3, 2007, p. 405-409.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The translocations t(6;18;11)(q24;q21;q21) and t(11;14;18)(q21;q32;q21) lead to a fusion of the API2 and MALT1 genes and occur in MALT lymphomas.
AU - Murga-Penas, Eva-Maria
AU - Eva, M
AU - Callet-Bauchu, Evelyne
AU - Ye, Hongtao
AU - Albert, Nadine
AU - Albert, Nadine
AU - Copie-Bergman, Christiane
AU - Gazzo, Sophie
AU - Berger, Françoise
AU - Bokemeyer, Carsten
AU - Bokemeyer, Carsten
AU - Dierlamm, Judith
AU - Dierlamm, Judith
PY - 2007
Y1 - 2007
N2 - So far, only one variant translocation of the t(11;18)(q21;q21), the t(11;12;18) (q21;q13;q21), has been reported. We herein describe two new variant translocations, the t(6;18;11)(q24;q21;q21) and the t(11;14;18)(q21;q32;q21), occurring in mucosa-associated lymphoid tissue (MALT) lymphomas. In both cases, fluorescence in situ hybridization (FISH) and reverse transcriptase polymerase chain reaction (RT-PCR) revealed the presence of an 5'API2-3'MALT1 fusion product, encoded on the derivative chromosome 11. Exon 7 of API2 was fused with exon 5 of MALT1 in the t(11;14;18) and with exon 8 of MALT1 in the t(6;18;11). FISH revealed the involvement of the immunoglobulin locus in the t(11;14;18). Rapid amplification of cDNA ends (RACE)-PCR to detect the involved partner gene on 6q showed exclusively wild-type API2 and MALT1 sequences.
AB - So far, only one variant translocation of the t(11;18)(q21;q21), the t(11;12;18) (q21;q13;q21), has been reported. We herein describe two new variant translocations, the t(6;18;11)(q24;q21;q21) and the t(11;14;18)(q21;q32;q21), occurring in mucosa-associated lymphoid tissue (MALT) lymphomas. In both cases, fluorescence in situ hybridization (FISH) and reverse transcriptase polymerase chain reaction (RT-PCR) revealed the presence of an 5'API2-3'MALT1 fusion product, encoded on the derivative chromosome 11. Exon 7 of API2 was fused with exon 5 of MALT1 in the t(11;14;18) and with exon 8 of MALT1 in the t(6;18;11). FISH revealed the involvement of the immunoglobulin locus in the t(11;14;18). Rapid amplification of cDNA ends (RACE)-PCR to detect the involved partner gene on 6q showed exclusively wild-type API2 and MALT1 sequences.
U2 - 10.3324/haematol.10268
DO - 10.3324/haematol.10268
M3 - SCORING: Zeitschriftenaufsatz
VL - 92
SP - 405
EP - 409
JO - HAEMATOLOGICA
JF - HAEMATOLOGICA
SN - 0390-6078
IS - 3
M1 - 3
ER -