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The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

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The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. / Schugar, Rebecca C; Shih, Diana M; Warrier, Manya; Helsley, Robert N; Burrows, Amy; Ferguson, Daniel; Brown, Amanda L; Gromovsky, Anthony D; Heine, Markus; Chatterjee, Arunachal; Li, Lin; Li, Xinmin S; Wang, Zeneng; Willard, Belinda; Meng, YongHong; Kim, Hanjun; Che, Nam; Pan, Calvin; Lee, Richard G; Crooke, Rosanne M; Graham, Mark J; Morton, Richard E; Langefeld, Carl D; Das, Swapan K; Rudel, Lawrence L; Zein, Nizar; McCullough, Arthur J; Dasarathy, Srinivasan; Tang, W H Wilson; Erokwu, Bernadette O; Flask, Chris A; Laakso, Markku; Civelek, Mete; Naga Prasad, Sathyamangla V; Heeren, Joerg; Lusis, Aldons J; Hazen, Stanley L; Brown, J Mark.

In: CELL REP, Vol. 19, No. 12, 20.06.2017, p. 2451-2461.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schugar, RC, Shih, DM, Warrier, M, Helsley, RN, Burrows, A, Ferguson, D, Brown, AL, Gromovsky, AD, Heine, M, Chatterjee, A, Li, L, Li, XS, Wang, Z, Willard, B, Meng, Y, Kim, H, Che, N, Pan, C, Lee, RG, Crooke, RM, Graham, MJ, Morton, RE, Langefeld, CD, Das, SK, Rudel, LL, Zein, N, McCullough, AJ, Dasarathy, S, Tang, WHW, Erokwu, BO, Flask, CA, Laakso, M, Civelek, M, Naga Prasad, SV, Heeren, J, Lusis, AJ, Hazen, SL & Brown, JM 2017, 'The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue', CELL REP, vol. 19, no. 12, pp. 2451-2461. https://doi.org/10.1016/j.celrep.2017.05.077

APA

Schugar, R. C., Shih, D. M., Warrier, M., Helsley, R. N., Burrows, A., Ferguson, D., Brown, A. L., Gromovsky, A. D., Heine, M., Chatterjee, A., Li, L., Li, X. S., Wang, Z., Willard, B., Meng, Y., Kim, H., Che, N., Pan, C., Lee, R. G., ... Brown, J. M. (2017). The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. CELL REP, 19(12), 2451-2461. https://doi.org/10.1016/j.celrep.2017.05.077

Vancouver

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D et al. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. CELL REP. 2017 Jun 20;19(12):2451-2461. https://doi.org/10.1016/j.celrep.2017.05.077

Bibtex

@article{5a09bccb215e484b91313e5d0085114e,
title = "The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue",
abstract = "Emerging evidence suggests that microbes resident in the human intestine represent a key environmental factor contributing to obesity-associated disorders. Here, we demonstrate that the gut microbiota-initiated trimethylamine N-oxide (TMAO)-generating pathway is linked to obesity and energy metabolism. In multiple clinical cohorts, systemic levels of TMAO were observed to strongly associate with type 2 diabetes. In addition, circulating TMAO levels were associated with obesity traits in the different inbred strains represented in the Hybrid Mouse Diversity Panel. Further, antisense oligonucleotide-mediated knockdown or genetic deletion of the TMAO-producing enzyme flavin-containing monooxygenase 3 (FMO3) conferred protection against obesity in mice. Complimentary mouse and human studies indicate a negative regulatory role for FMO3 in the beiging of white adipose tissue. Collectively, our studies reveal a link between the TMAO-producing enzyme FMO3 and obesity and the beiging of white adipose tissue.",
keywords = "Journal Article",
author = "Schugar, {Rebecca C} and Shih, {Diana M} and Manya Warrier and Helsley, {Robert N} and Amy Burrows and Daniel Ferguson and Brown, {Amanda L} and Gromovsky, {Anthony D} and Markus Heine and Arunachal Chatterjee and Lin Li and Li, {Xinmin S} and Zeneng Wang and Belinda Willard and YongHong Meng and Hanjun Kim and Nam Che and Calvin Pan and Lee, {Richard G} and Crooke, {Rosanne M} and Graham, {Mark J} and Morton, {Richard E} and Langefeld, {Carl D} and Das, {Swapan K} and Rudel, {Lawrence L} and Nizar Zein and McCullough, {Arthur J} and Srinivasan Dasarathy and Tang, {W H Wilson} and Erokwu, {Bernadette O} and Flask, {Chris A} and Markku Laakso and Mete Civelek and {Naga Prasad}, {Sathyamangla V} and Joerg Heeren and Lusis, {Aldons J} and Hazen, {Stanley L} and Brown, {J Mark}",
note = "Copyright {\textcopyright} 2017 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = jun,
day = "20",
doi = "10.1016/j.celrep.2017.05.077",
language = "English",
volume = "19",
pages = "2451--2461",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

AU - Schugar, Rebecca C

AU - Shih, Diana M

AU - Warrier, Manya

AU - Helsley, Robert N

AU - Burrows, Amy

AU - Ferguson, Daniel

AU - Brown, Amanda L

AU - Gromovsky, Anthony D

AU - Heine, Markus

AU - Chatterjee, Arunachal

AU - Li, Lin

AU - Li, Xinmin S

AU - Wang, Zeneng

AU - Willard, Belinda

AU - Meng, YongHong

AU - Kim, Hanjun

AU - Che, Nam

AU - Pan, Calvin

AU - Lee, Richard G

AU - Crooke, Rosanne M

AU - Graham, Mark J

AU - Morton, Richard E

AU - Langefeld, Carl D

AU - Das, Swapan K

AU - Rudel, Lawrence L

AU - Zein, Nizar

AU - McCullough, Arthur J

AU - Dasarathy, Srinivasan

AU - Tang, W H Wilson

AU - Erokwu, Bernadette O

AU - Flask, Chris A

AU - Laakso, Markku

AU - Civelek, Mete

AU - Naga Prasad, Sathyamangla V

AU - Heeren, Joerg

AU - Lusis, Aldons J

AU - Hazen, Stanley L

AU - Brown, J Mark

N1 - Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2017/6/20

Y1 - 2017/6/20

N2 - Emerging evidence suggests that microbes resident in the human intestine represent a key environmental factor contributing to obesity-associated disorders. Here, we demonstrate that the gut microbiota-initiated trimethylamine N-oxide (TMAO)-generating pathway is linked to obesity and energy metabolism. In multiple clinical cohorts, systemic levels of TMAO were observed to strongly associate with type 2 diabetes. In addition, circulating TMAO levels were associated with obesity traits in the different inbred strains represented in the Hybrid Mouse Diversity Panel. Further, antisense oligonucleotide-mediated knockdown or genetic deletion of the TMAO-producing enzyme flavin-containing monooxygenase 3 (FMO3) conferred protection against obesity in mice. Complimentary mouse and human studies indicate a negative regulatory role for FMO3 in the beiging of white adipose tissue. Collectively, our studies reveal a link between the TMAO-producing enzyme FMO3 and obesity and the beiging of white adipose tissue.

AB - Emerging evidence suggests that microbes resident in the human intestine represent a key environmental factor contributing to obesity-associated disorders. Here, we demonstrate that the gut microbiota-initiated trimethylamine N-oxide (TMAO)-generating pathway is linked to obesity and energy metabolism. In multiple clinical cohorts, systemic levels of TMAO were observed to strongly associate with type 2 diabetes. In addition, circulating TMAO levels were associated with obesity traits in the different inbred strains represented in the Hybrid Mouse Diversity Panel. Further, antisense oligonucleotide-mediated knockdown or genetic deletion of the TMAO-producing enzyme flavin-containing monooxygenase 3 (FMO3) conferred protection against obesity in mice. Complimentary mouse and human studies indicate a negative regulatory role for FMO3 in the beiging of white adipose tissue. Collectively, our studies reveal a link between the TMAO-producing enzyme FMO3 and obesity and the beiging of white adipose tissue.

KW - Journal Article

U2 - 10.1016/j.celrep.2017.05.077

DO - 10.1016/j.celrep.2017.05.077

M3 - SCORING: Journal article

C2 - 28636934

VL - 19

SP - 2451

EP - 2461

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 12

ER -