The three sorCS genes are differentially expressed and regulated by synaptic activity.
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The three sorCS genes are differentially expressed and regulated by synaptic activity. / Hermey, Guido; Plath, Niels; Hübner, Christian A; Kuhl, Dietmar; Schaller, H Chica; Hermans-Borgmeyer, Irm.
In: J NEUROCHEM, Vol. 88, No. 6, 6, 2004, p. 1470-1476.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The three sorCS genes are differentially expressed and regulated by synaptic activity.
AU - Hermey, Guido
AU - Plath, Niels
AU - Hübner, Christian A
AU - Kuhl, Dietmar
AU - Schaller, H Chica
AU - Hermans-Borgmeyer, Irm
PY - 2004
Y1 - 2004
N2 - We have isolated the murine sorCS3 gene, a new member of the family of receptors containing a Vps10p-domain. Receptors of this family facilitate rapid endocytosis and are thought to be involved in intracellular sorting. SorCS3 and the highly homologous sorCS1 and sorCS2 genes were expressed in a combinatorial, mostly non-overlapping pattern in both the developing and mature central nervous system. During development, distribution and abundancy of their transcripts was regulated. Moreover, their expression was differentially influenced by neuronal activity in the hippocampus of adult mice. Although kainic acid-induced seizures had no effect on sorCS2 mRNA levels, they dramatically increased the expression of sorCS1 and sorCS3. The activity-dependent induction of sorCS1 expression required de novo protein synthesis, whereas that of sorCS3 did not. Our results imply that the three sorCS genes have diverse, but partly overlapping functions in the developing and mature central nervous system.
AB - We have isolated the murine sorCS3 gene, a new member of the family of receptors containing a Vps10p-domain. Receptors of this family facilitate rapid endocytosis and are thought to be involved in intracellular sorting. SorCS3 and the highly homologous sorCS1 and sorCS2 genes were expressed in a combinatorial, mostly non-overlapping pattern in both the developing and mature central nervous system. During development, distribution and abundancy of their transcripts was regulated. Moreover, their expression was differentially influenced by neuronal activity in the hippocampus of adult mice. Although kainic acid-induced seizures had no effect on sorCS2 mRNA levels, they dramatically increased the expression of sorCS1 and sorCS3. The activity-dependent induction of sorCS1 expression required de novo protein synthesis, whereas that of sorCS3 did not. Our results imply that the three sorCS genes have diverse, but partly overlapping functions in the developing and mature central nervous system.
M3 - SCORING: Zeitschriftenaufsatz
VL - 88
SP - 1470
EP - 1476
JO - J NEUROCHEM
JF - J NEUROCHEM
SN - 0022-3042
IS - 6
M1 - 6
ER -
