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The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma.

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The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma. / Murga-Penas, Eva-Maria; Maria, Eva; Callet-Bauchu, Evelyne; Ye, Hongtao; Gazzo, Sophie; Schilling, Georgia; Schilling, Georgia; Vettorazzi, Eik; Vettorazzi, Eik; Salles, Gilles; Wlodarska, Iwona; Bokemeyer, Carsten; Dierlamm, Judith; Dierlamm, Judith.

In: BLOOD, 2009.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Murga-Penas, E-M, Maria, E, Callet-Bauchu, E, Ye, H, Gazzo, S, Schilling, G, Schilling, G, Vettorazzi, E, Vettorazzi, E, Salles, G, Wlodarska, I, Bokemeyer, C, Dierlamm, J & Dierlamm, J 2009, 'The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma.', BLOOD. <http://www.ncbi.nlm.nih.gov/pubmed/19965626?dopt=Citation>

APA

Murga-Penas, E-M., Maria, E., Callet-Bauchu, E., Ye, H., Gazzo, S., Schilling, G., Schilling, G., Vettorazzi, E., Vettorazzi, E., Salles, G., Wlodarska, I., Bokemeyer, C., Dierlamm, J., & Dierlamm, J. (2009). The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma. BLOOD. http://www.ncbi.nlm.nih.gov/pubmed/19965626?dopt=Citation

Vancouver

Murga-Penas E-M, Maria E, Callet-Bauchu E, Ye H, Gazzo S, Schilling G et al. The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma. BLOOD. 2009.

Bibtex

@article{723da30ec1144601b0e040d56ab87065,
title = "The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma.",
abstract = "The t(14;18)(q32;q21) involving the immunoglobulin heavy chain locus (IGH) and the MALT1 gene is a recurrent abnormality in MALT lymphomas. However, the nucleotide sequence of only one t(14;18)-positive MALT lymphoma has been reported so far. We here report the molecular characterization of the IGH-MALT1 fusion products in 5 new cases of t(14;18)-positive MALT lymphomas. Similar to the IGH-associated translocations in follicular and mantle cell lymphomas, the IGH-MALT1 junctions in MALT lymphoma showed all features of a recombination signal sequence (RSS)-guided V(D)J-mediated translocation at the IGH locus. Furthermore, analogous to follicular and mantle cell lymphoma, templated T-nucleotides were identified at the t(14;18)/IGH-MALT1 breakpoint junctions. On chromosome 18, we identified a novel major breakpoint region (MBR) in MALT1 upstream of its coding region. Moreover, the presence of duplications of MALT1 nucleotides in one case suggests an underlying staggered DNA-break process not consistent with V(D)J-mediated recombination. The molecular characteristics of the t(14;18)/IGH-MALT1 resemble those found in the t(14;18)/IGH-BCL2 in FL and t(11;14)/CCND1-IGH in MCL suggesting that these translocations could be generated by common pathomechanisms involving illegitime V(D)J-mediated recombination on IGH as well as new synthesis of T-nucleotides and non-homologous end joining (NHEJ) or alternative NHEJ repair pathways on the IGH-translocation partner.",
author = "Eva-Maria Murga-Penas and Eva Maria and Evelyne Callet-Bauchu and Hongtao Ye and Sophie Gazzo and Georgia Schilling and Georgia Schilling and Eik Vettorazzi and Eik Vettorazzi and Gilles Salles and Iwona Wlodarska and Carsten Bokemeyer and Judith Dierlamm and Judith Dierlamm",
year = "2009",
language = "Deutsch",
journal = "BLOOD",
issn = "0006-4971",
publisher = "American Society of Hematology",

}

RIS

TY - JOUR

T1 - The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma.

AU - Murga-Penas, Eva-Maria

AU - Maria, Eva

AU - Callet-Bauchu, Evelyne

AU - Ye, Hongtao

AU - Gazzo, Sophie

AU - Schilling, Georgia

AU - Schilling, Georgia

AU - Vettorazzi, Eik

AU - Vettorazzi, Eik

AU - Salles, Gilles

AU - Wlodarska, Iwona

AU - Bokemeyer, Carsten

AU - Dierlamm, Judith

AU - Dierlamm, Judith

PY - 2009

Y1 - 2009

N2 - The t(14;18)(q32;q21) involving the immunoglobulin heavy chain locus (IGH) and the MALT1 gene is a recurrent abnormality in MALT lymphomas. However, the nucleotide sequence of only one t(14;18)-positive MALT lymphoma has been reported so far. We here report the molecular characterization of the IGH-MALT1 fusion products in 5 new cases of t(14;18)-positive MALT lymphomas. Similar to the IGH-associated translocations in follicular and mantle cell lymphomas, the IGH-MALT1 junctions in MALT lymphoma showed all features of a recombination signal sequence (RSS)-guided V(D)J-mediated translocation at the IGH locus. Furthermore, analogous to follicular and mantle cell lymphoma, templated T-nucleotides were identified at the t(14;18)/IGH-MALT1 breakpoint junctions. On chromosome 18, we identified a novel major breakpoint region (MBR) in MALT1 upstream of its coding region. Moreover, the presence of duplications of MALT1 nucleotides in one case suggests an underlying staggered DNA-break process not consistent with V(D)J-mediated recombination. The molecular characteristics of the t(14;18)/IGH-MALT1 resemble those found in the t(14;18)/IGH-BCL2 in FL and t(11;14)/CCND1-IGH in MCL suggesting that these translocations could be generated by common pathomechanisms involving illegitime V(D)J-mediated recombination on IGH as well as new synthesis of T-nucleotides and non-homologous end joining (NHEJ) or alternative NHEJ repair pathways on the IGH-translocation partner.

AB - The t(14;18)(q32;q21) involving the immunoglobulin heavy chain locus (IGH) and the MALT1 gene is a recurrent abnormality in MALT lymphomas. However, the nucleotide sequence of only one t(14;18)-positive MALT lymphoma has been reported so far. We here report the molecular characterization of the IGH-MALT1 fusion products in 5 new cases of t(14;18)-positive MALT lymphomas. Similar to the IGH-associated translocations in follicular and mantle cell lymphomas, the IGH-MALT1 junctions in MALT lymphoma showed all features of a recombination signal sequence (RSS)-guided V(D)J-mediated translocation at the IGH locus. Furthermore, analogous to follicular and mantle cell lymphoma, templated T-nucleotides were identified at the t(14;18)/IGH-MALT1 breakpoint junctions. On chromosome 18, we identified a novel major breakpoint region (MBR) in MALT1 upstream of its coding region. Moreover, the presence of duplications of MALT1 nucleotides in one case suggests an underlying staggered DNA-break process not consistent with V(D)J-mediated recombination. The molecular characteristics of the t(14;18)/IGH-MALT1 resemble those found in the t(14;18)/IGH-BCL2 in FL and t(11;14)/CCND1-IGH in MCL suggesting that these translocations could be generated by common pathomechanisms involving illegitime V(D)J-mediated recombination on IGH as well as new synthesis of T-nucleotides and non-homologous end joining (NHEJ) or alternative NHEJ repair pathways on the IGH-translocation partner.

M3 - SCORING: Zeitschriftenaufsatz

JO - BLOOD

JF - BLOOD

SN - 0006-4971

ER -