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The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells

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The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells. / Hütz, Katharina; Mejías-Luque, Raquel; Farsakova, Katarina; Ogris, Manfred; Krebs, Stefan; Anton, Martina; Vieth, Michael; Schüller, Ulrich; Schneider, Marlon R; Blum, Helmut; Wagner, Ernst; Jung, Andreas; Gerhard, Markus.

In: CARCINOGENESIS, Vol. 35, No. 4, 04.2014, p. 942-50.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hütz, K, Mejías-Luque, R, Farsakova, K, Ogris, M, Krebs, S, Anton, M, Vieth, M, Schüller, U, Schneider, MR, Blum, H, Wagner, E, Jung, A & Gerhard, M 2014, 'The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells', CARCINOGENESIS, vol. 35, no. 4, pp. 942-50. https://doi.org/10.1093/carcin/bgt410

APA

Hütz, K., Mejías-Luque, R., Farsakova, K., Ogris, M., Krebs, S., Anton, M., Vieth, M., Schüller, U., Schneider, M. R., Blum, H., Wagner, E., Jung, A., & Gerhard, M. (2014). The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells. CARCINOGENESIS, 35(4), 942-50. https://doi.org/10.1093/carcin/bgt410

Vancouver

Hütz K, Mejías-Luque R, Farsakova K, Ogris M, Krebs S, Anton M et al. The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells. CARCINOGENESIS. 2014 Apr;35(4):942-50. https://doi.org/10.1093/carcin/bgt410

Bibtex

@article{98b2534eba9b483cae390a71197d88e6,
title = "The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells",
abstract = "Gastric cancer (GC) is still one of the most common causes of cancer-related death worldwide, which is mainly attributable to late diagnosis and poor treatment options. Infection with Helicobacter pylori, different environmental factors and genetic alterations are known to influence the risk of developing gastric tumors. However, the molecular mechanisms involved in gastric carcinogenesis are still not fully understood, making it difficult to design targeted therapeutic approaches. Aberrant expression of the specific gastric differentiation marker SOX2 has been observed in stomach cancer. However, the role of SOX2 in gastric tumors has not been well established to date. To elucidate the role of SOX2 in gastric tumorigenesis, SOX2 transcriptional activity was blocked in AZ-521 cells. Interestingly, inhibition of SOX2 reduced cell proliferation and migration, increased apoptosis and induced changes in cell cycle. Blocking of SOX2 also reduced the tumorigenic potential of AZ-521 cells in vivo. In addition, correlation of SOX2 expression and proliferation was observed in a subset of human gastric tumors. Finally, target genes of SOX2 were for the first time identified by RNA microarray in GC cells. Taken together, the results presented here indicate that SOX2 controls several aspects related to GC development and progression by regulating the expression of members of important signaling pathways. These findings could provide new therapeutic options for a subset of GCs exhibiting SOX2 deregulation.",
keywords = "Animals, Base Sequence, Carcinogenesis, Cell Line, Tumor, DNA Primers, Female, Humans, Mice, Real-Time Polymerase Chain Reaction, SOXB1 Transcription Factors, Stomach Neoplasms, Journal Article, Research Support, Non-U.S. Gov't",
author = "Katharina H{\"u}tz and Raquel Mej{\'i}as-Luque and Katarina Farsakova and Manfred Ogris and Stefan Krebs and Martina Anton and Michael Vieth and Ulrich Sch{\"u}ller and Schneider, {Marlon R} and Helmut Blum and Ernst Wagner and Andreas Jung and Markus Gerhard",
year = "2014",
month = apr,
doi = "10.1093/carcin/bgt410",
language = "English",
volume = "35",
pages = "942--50",
journal = "CARCINOGENESIS",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells

AU - Hütz, Katharina

AU - Mejías-Luque, Raquel

AU - Farsakova, Katarina

AU - Ogris, Manfred

AU - Krebs, Stefan

AU - Anton, Martina

AU - Vieth, Michael

AU - Schüller, Ulrich

AU - Schneider, Marlon R

AU - Blum, Helmut

AU - Wagner, Ernst

AU - Jung, Andreas

AU - Gerhard, Markus

PY - 2014/4

Y1 - 2014/4

N2 - Gastric cancer (GC) is still one of the most common causes of cancer-related death worldwide, which is mainly attributable to late diagnosis and poor treatment options. Infection with Helicobacter pylori, different environmental factors and genetic alterations are known to influence the risk of developing gastric tumors. However, the molecular mechanisms involved in gastric carcinogenesis are still not fully understood, making it difficult to design targeted therapeutic approaches. Aberrant expression of the specific gastric differentiation marker SOX2 has been observed in stomach cancer. However, the role of SOX2 in gastric tumors has not been well established to date. To elucidate the role of SOX2 in gastric tumorigenesis, SOX2 transcriptional activity was blocked in AZ-521 cells. Interestingly, inhibition of SOX2 reduced cell proliferation and migration, increased apoptosis and induced changes in cell cycle. Blocking of SOX2 also reduced the tumorigenic potential of AZ-521 cells in vivo. In addition, correlation of SOX2 expression and proliferation was observed in a subset of human gastric tumors. Finally, target genes of SOX2 were for the first time identified by RNA microarray in GC cells. Taken together, the results presented here indicate that SOX2 controls several aspects related to GC development and progression by regulating the expression of members of important signaling pathways. These findings could provide new therapeutic options for a subset of GCs exhibiting SOX2 deregulation.

AB - Gastric cancer (GC) is still one of the most common causes of cancer-related death worldwide, which is mainly attributable to late diagnosis and poor treatment options. Infection with Helicobacter pylori, different environmental factors and genetic alterations are known to influence the risk of developing gastric tumors. However, the molecular mechanisms involved in gastric carcinogenesis are still not fully understood, making it difficult to design targeted therapeutic approaches. Aberrant expression of the specific gastric differentiation marker SOX2 has been observed in stomach cancer. However, the role of SOX2 in gastric tumors has not been well established to date. To elucidate the role of SOX2 in gastric tumorigenesis, SOX2 transcriptional activity was blocked in AZ-521 cells. Interestingly, inhibition of SOX2 reduced cell proliferation and migration, increased apoptosis and induced changes in cell cycle. Blocking of SOX2 also reduced the tumorigenic potential of AZ-521 cells in vivo. In addition, correlation of SOX2 expression and proliferation was observed in a subset of human gastric tumors. Finally, target genes of SOX2 were for the first time identified by RNA microarray in GC cells. Taken together, the results presented here indicate that SOX2 controls several aspects related to GC development and progression by regulating the expression of members of important signaling pathways. These findings could provide new therapeutic options for a subset of GCs exhibiting SOX2 deregulation.

KW - Animals

KW - Base Sequence

KW - Carcinogenesis

KW - Cell Line, Tumor

KW - DNA Primers

KW - Female

KW - Humans

KW - Mice

KW - Real-Time Polymerase Chain Reaction

KW - SOXB1 Transcription Factors

KW - Stomach Neoplasms

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1093/carcin/bgt410

DO - 10.1093/carcin/bgt410

M3 - SCORING: Journal article

C2 - 24325912

VL - 35

SP - 942

EP - 950

JO - CARCINOGENESIS

JF - CARCINOGENESIS

SN - 0143-3334

IS - 4

ER -