The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.
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The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. / Flores-Santana, Wilmarie; Salmon, Debra J; Donzelli, Sonia; Switzer, Christopher H; Basudhar, Debashree; Ridnour, Lisa; Cheng, Robert; Glynn, Sharon A; Paolocci, Nazareno; Fukuto, Jon M; Miranda, Katrina M; Wink, David A.
In: ANTIOXID REDOX SIGN, Vol. 14, No. 9, 9, 2011, p. 1659-1674.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.
AU - Flores-Santana, Wilmarie
AU - Salmon, Debra J
AU - Donzelli, Sonia
AU - Switzer, Christopher H
AU - Basudhar, Debashree
AU - Ridnour, Lisa
AU - Cheng, Robert
AU - Glynn, Sharon A
AU - Paolocci, Nazareno
AU - Fukuto, Jon M
AU - Miranda, Katrina M
AU - Wink, David A
PY - 2011
Y1 - 2011
N2 - The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review.
AB - The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review.
KW - Animals
KW - Humans
KW - Metalloproteins/chemistry/metabolism
KW - Nitrogen Oxides/chemistry/metabolism
KW - Sulfhydryl Compounds/chemistry/metabolism
KW - Animals
KW - Humans
KW - Metalloproteins/chemistry/metabolism
KW - Nitrogen Oxides/chemistry/metabolism
KW - Sulfhydryl Compounds/chemistry/metabolism
M3 - SCORING: Journal article
VL - 14
SP - 1659
EP - 1674
JO - ANTIOXID REDOX SIGN
JF - ANTIOXID REDOX SIGN
SN - 1523-0864
IS - 9
M1 - 9
ER -