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The sensitivity and specificity of the OralCDx technique

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The sensitivity and specificity of the OralCDx technique : evaluation of 103 cases. / Scheifele, Christian; Schmidt-Westhausen, Andrea-Maria; Dietrich, Thomas; Reichart, Peter A.

In: ORAL ONCOL, Vol. 40, No. 8, 01.09.2004, p. 824-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Scheifele, C, Schmidt-Westhausen, A-M, Dietrich, T & Reichart, PA 2004, 'The sensitivity and specificity of the OralCDx technique: evaluation of 103 cases', ORAL ONCOL, vol. 40, no. 8, pp. 824-8. https://doi.org/10.1016/j.oraloncology.2004.02.004

APA

Scheifele, C., Schmidt-Westhausen, A-M., Dietrich, T., & Reichart, P. A. (2004). The sensitivity and specificity of the OralCDx technique: evaluation of 103 cases. ORAL ONCOL, 40(8), 824-8. https://doi.org/10.1016/j.oraloncology.2004.02.004

Vancouver

Scheifele C, Schmidt-Westhausen A-M, Dietrich T, Reichart PA. The sensitivity and specificity of the OralCDx technique: evaluation of 103 cases. ORAL ONCOL. 2004 Sep 1;40(8):824-8. https://doi.org/10.1016/j.oraloncology.2004.02.004

Bibtex

@article{1a8e30fc5e844399a965aa99c2f3afa0,
title = "The sensitivity and specificity of the OralCDx technique: evaluation of 103 cases",
abstract = "In this study, we compared 103 OralCDx results with the histological findings of 96 clinical sites in 80 patients (33 females; 64.3+/-13.7 years and 47 males; 53.2+/-11.5 years). The histological findings were classified as follows: compatible with oral leukoplakia (OL; n = 60) or oral lichen planus (OLP; n = 17), both without dysplasia; dysplasia in OL or OLP (n = 9); and oral squamous cell carcinoma (OSCC; n = 17). There were seven (6.8%) specimens with an inadequate cell count. Overall, the sensitivity of the OralCDx technique to detect dysplasia and OSCC was 92.3% (95% CI: 74.9-99.1%), and the specificity was 94.3% (95% CI: 86.0-98.4%). The positive likelihood ratio (LR+) was 16.2 (95% CI: 6.2-42.1) and the negative likelihood ratio (LR-) was 0.08 (95% CI: 0.02-0.31). In conclusion, these figures are in agreement with previously published data and support the use of OralCDx as a screening tool of oral lesions, but further trials are still necessary.",
keywords = "Biopsy/methods, Diagnosis, Computer-Assisted/methods, Female, Humans, Leukoplakia, Oral/diagnosis, Lichen Planus, Oral/diagnosis, Likelihood Functions, Male, Middle Aged, Mouth Mucosa/pathology, Mouth Neoplasms/diagnosis, Sensitivity and Specificity",
author = "Christian Scheifele and Andrea-Maria Schmidt-Westhausen and Thomas Dietrich and Reichart, {Peter A}",
year = "2004",
month = sep,
day = "1",
doi = "10.1016/j.oraloncology.2004.02.004",
language = "English",
volume = "40",
pages = "824--8",
journal = "ORAL ONCOL",
issn = "1368-8375",
publisher = "Elsevier Limited",
number = "8",

}

RIS

TY - JOUR

T1 - The sensitivity and specificity of the OralCDx technique

T2 - evaluation of 103 cases

AU - Scheifele, Christian

AU - Schmidt-Westhausen, Andrea-Maria

AU - Dietrich, Thomas

AU - Reichart, Peter A

PY - 2004/9/1

Y1 - 2004/9/1

N2 - In this study, we compared 103 OralCDx results with the histological findings of 96 clinical sites in 80 patients (33 females; 64.3+/-13.7 years and 47 males; 53.2+/-11.5 years). The histological findings were classified as follows: compatible with oral leukoplakia (OL; n = 60) or oral lichen planus (OLP; n = 17), both without dysplasia; dysplasia in OL or OLP (n = 9); and oral squamous cell carcinoma (OSCC; n = 17). There were seven (6.8%) specimens with an inadequate cell count. Overall, the sensitivity of the OralCDx technique to detect dysplasia and OSCC was 92.3% (95% CI: 74.9-99.1%), and the specificity was 94.3% (95% CI: 86.0-98.4%). The positive likelihood ratio (LR+) was 16.2 (95% CI: 6.2-42.1) and the negative likelihood ratio (LR-) was 0.08 (95% CI: 0.02-0.31). In conclusion, these figures are in agreement with previously published data and support the use of OralCDx as a screening tool of oral lesions, but further trials are still necessary.

AB - In this study, we compared 103 OralCDx results with the histological findings of 96 clinical sites in 80 patients (33 females; 64.3+/-13.7 years and 47 males; 53.2+/-11.5 years). The histological findings were classified as follows: compatible with oral leukoplakia (OL; n = 60) or oral lichen planus (OLP; n = 17), both without dysplasia; dysplasia in OL or OLP (n = 9); and oral squamous cell carcinoma (OSCC; n = 17). There were seven (6.8%) specimens with an inadequate cell count. Overall, the sensitivity of the OralCDx technique to detect dysplasia and OSCC was 92.3% (95% CI: 74.9-99.1%), and the specificity was 94.3% (95% CI: 86.0-98.4%). The positive likelihood ratio (LR+) was 16.2 (95% CI: 6.2-42.1) and the negative likelihood ratio (LR-) was 0.08 (95% CI: 0.02-0.31). In conclusion, these figures are in agreement with previously published data and support the use of OralCDx as a screening tool of oral lesions, but further trials are still necessary.

KW - Biopsy/methods

KW - Diagnosis, Computer-Assisted/methods

KW - Female

KW - Humans

KW - Leukoplakia, Oral/diagnosis

KW - Lichen Planus, Oral/diagnosis

KW - Likelihood Functions

KW - Male

KW - Middle Aged

KW - Mouth Mucosa/pathology

KW - Mouth Neoplasms/diagnosis

KW - Sensitivity and Specificity

U2 - 10.1016/j.oraloncology.2004.02.004

DO - 10.1016/j.oraloncology.2004.02.004

M3 - SCORING: Journal article

C2 - 15288838

VL - 40

SP - 824

EP - 828

JO - ORAL ONCOL

JF - ORAL ONCOL

SN - 1368-8375

IS - 8

ER -