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The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

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The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms. / Duménieu, Maël; Oulé, Marie; Kreutz, Michael R; Lopez-Rojas, Jeffrey.

In: FRONT CELL NEUROSCI, Vol. 11, 2017, p. 115.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Duménieu, M, Oulé, M, Kreutz, MR & Lopez-Rojas, J 2017, 'The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms', FRONT CELL NEUROSCI, vol. 11, pp. 115. https://doi.org/10.3389/fncel.2017.00115

APA

Duménieu, M., Oulé, M., Kreutz, M. R., & Lopez-Rojas, J. (2017). The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms. FRONT CELL NEUROSCI, 11, 115. https://doi.org/10.3389/fncel.2017.00115

Vancouver

Duménieu M, Oulé M, Kreutz MR, Lopez-Rojas J. The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms. FRONT CELL NEUROSCI. 2017;11:115. https://doi.org/10.3389/fncel.2017.00115

Bibtex

@article{6204401520414940b38636be4bf9ffa9,
title = "The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms",
abstract = "Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expression of voltage-gated ion channels (VGCs). Several studies show an uneven distribution of ion channels and their differential regulation within dendrites and axons, which is a prerequisite for an appropriate integration of synaptic inputs and the generation of adequate action potential (AP) firing patterns. This review article will focus on the signaling pathways leading to segmented expression of voltage-gated potassium and sodium ion channels at the neuronal plasma membrane and the regulatory mechanisms ensuring segregated functions. We will also discuss the relevance of proper ion channel targeting for neuronal physiology and how alterations in polarized distribution contribute to neuronal pathology.",
keywords = "Journal Article",
author = "Ma{\"e}l Dum{\'e}nieu and Marie Oul{\'e} and Kreutz, {Michael R} and Jeffrey Lopez-Rojas",
year = "2017",
doi = "10.3389/fncel.2017.00115",
language = "English",
volume = "11",
pages = "115",
journal = "FRONT CELL NEUROSCI",
issn = "1662-5102",
publisher = "Frontiers Media",

}

RIS

TY - JOUR

T1 - The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

AU - Duménieu, Maël

AU - Oulé, Marie

AU - Kreutz, Michael R

AU - Lopez-Rojas, Jeffrey

PY - 2017

Y1 - 2017

N2 - Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expression of voltage-gated ion channels (VGCs). Several studies show an uneven distribution of ion channels and their differential regulation within dendrites and axons, which is a prerequisite for an appropriate integration of synaptic inputs and the generation of adequate action potential (AP) firing patterns. This review article will focus on the signaling pathways leading to segmented expression of voltage-gated potassium and sodium ion channels at the neuronal plasma membrane and the regulatory mechanisms ensuring segregated functions. We will also discuss the relevance of proper ion channel targeting for neuronal physiology and how alterations in polarized distribution contribute to neuronal pathology.

AB - Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expression of voltage-gated ion channels (VGCs). Several studies show an uneven distribution of ion channels and their differential regulation within dendrites and axons, which is a prerequisite for an appropriate integration of synaptic inputs and the generation of adequate action potential (AP) firing patterns. This review article will focus on the signaling pathways leading to segmented expression of voltage-gated potassium and sodium ion channels at the neuronal plasma membrane and the regulatory mechanisms ensuring segregated functions. We will also discuss the relevance of proper ion channel targeting for neuronal physiology and how alterations in polarized distribution contribute to neuronal pathology.

KW - Journal Article

U2 - 10.3389/fncel.2017.00115

DO - 10.3389/fncel.2017.00115

M3 - SCORING: Journal article

C2 - 28484374

VL - 11

SP - 115

JO - FRONT CELL NEUROSCI

JF - FRONT CELL NEUROSCI

SN - 1662-5102

ER -