Research ExplorerPublicationsThe role of Wnt proteins in arthritis

The role of Wnt proteins in arthritis

Standard

The role of Wnt proteins in arthritis. / Schett, Georg; Zwerina, Jochen; David, Jean-Pierre.

In: Nature clinical practice. Rheumatology, Vol. 4, No. 9, 01.09.2008, p. 473-80.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Schett, G, Zwerina, J & David, J-P 2008, 'The role of Wnt proteins in arthritis', Nature clinical practice. Rheumatology, vol. 4, no. 9, pp. 473-80. https://doi.org/10.1038/ncprheum0881

APA

Schett, G., Zwerina, J., & David, J-P. (2008). The role of Wnt proteins in arthritis. Nature clinical practice. Rheumatology, 4(9), 473-80. https://doi.org/10.1038/ncprheum0881

Vancouver

Schett G, Zwerina J, David J-P. The role of Wnt proteins in arthritis. Nature clinical practice. Rheumatology. 2008 Sep 1;4(9):473-80. https://doi.org/10.1038/ncprheum0881

Bibtex

@article{a309666559fc474b8ba0f5655334da8f,
title = "The role of Wnt proteins in arthritis",
abstract = "Wnt proteins regulate organ development, tumorigenesis and bone homeostasis, among other functions. The binding of Wnt proteins to plasma membrane receptors on mesenchymal cells induces the differentiation of these cells into the osteoblast lineage and thereby supports bone formation. Wnts are also key signaling proteins in joint remodeling processes. Active Wnt signaling contributes to osteophyte formation and might have an essential role in the anabolic pattern of joint remodeling that is observed in ankylosing spondylitis and osteoarthritis. By contrast, blockade of Wnt signaling facilitates bone erosion and contributes to catabolic joint remodeling, a process that is observed in rheumatoid arthritis. This Review summarizes current knowledge of the molecular regulation of joint remodeling associated with chronic arthritis, focusing on the role of the Wnt proteins and their inhibitors. It also addresses the role of Wnt in determining the differences in clinical presentation of inflammatory arthropathies and discusses implications for future therapy.",
keywords = "Arthritis, Bone Remodeling, Humans, Joints, Osteophyte, Signal Transduction, Wnt Proteins",
author = "Georg Schett and Jochen Zwerina and Jean-Pierre David",
year = "2008",
month = sep,
day = "1",
doi = "10.1038/ncprheum0881",
language = "English",
volume = "4",
pages = "473--80",
number = "9",

}

RIS

TY - JOUR

T1 - The role of Wnt proteins in arthritis

AU - Schett, Georg

AU - Zwerina, Jochen

AU - David, Jean-Pierre

PY - 2008/9/1

Y1 - 2008/9/1

N2 - Wnt proteins regulate organ development, tumorigenesis and bone homeostasis, among other functions. The binding of Wnt proteins to plasma membrane receptors on mesenchymal cells induces the differentiation of these cells into the osteoblast lineage and thereby supports bone formation. Wnts are also key signaling proteins in joint remodeling processes. Active Wnt signaling contributes to osteophyte formation and might have an essential role in the anabolic pattern of joint remodeling that is observed in ankylosing spondylitis and osteoarthritis. By contrast, blockade of Wnt signaling facilitates bone erosion and contributes to catabolic joint remodeling, a process that is observed in rheumatoid arthritis. This Review summarizes current knowledge of the molecular regulation of joint remodeling associated with chronic arthritis, focusing on the role of the Wnt proteins and their inhibitors. It also addresses the role of Wnt in determining the differences in clinical presentation of inflammatory arthropathies and discusses implications for future therapy.

AB - Wnt proteins regulate organ development, tumorigenesis and bone homeostasis, among other functions. The binding of Wnt proteins to plasma membrane receptors on mesenchymal cells induces the differentiation of these cells into the osteoblast lineage and thereby supports bone formation. Wnts are also key signaling proteins in joint remodeling processes. Active Wnt signaling contributes to osteophyte formation and might have an essential role in the anabolic pattern of joint remodeling that is observed in ankylosing spondylitis and osteoarthritis. By contrast, blockade of Wnt signaling facilitates bone erosion and contributes to catabolic joint remodeling, a process that is observed in rheumatoid arthritis. This Review summarizes current knowledge of the molecular regulation of joint remodeling associated with chronic arthritis, focusing on the role of the Wnt proteins and their inhibitors. It also addresses the role of Wnt in determining the differences in clinical presentation of inflammatory arthropathies and discusses implications for future therapy.

KW - Arthritis

KW - Bone Remodeling

KW - Humans

KW - Joints

KW - Osteophyte

KW - Signal Transduction

KW - Wnt Proteins

U2 - 10.1038/ncprheum0881

DO - 10.1038/ncprheum0881

M3 - SCORING: Journal article

C2 - 18756273

VL - 4

SP - 473

EP - 480

IS - 9

ER -