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The role of the cerebellum in the pathogenesis of cortical myoclonus

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The role of the cerebellum in the pathogenesis of cortical myoclonus. / Ganos, Christos; Kassavetis, Panagiotis; Erro, Roberto; Edwards, Mark J; Rothwell, John; Bhatia, Kailash P.

In: MOVEMENT DISORD, Vol. 29, No. 4, 01.04.2014, p. 437-43.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ganos, C, Kassavetis, P, Erro, R, Edwards, MJ, Rothwell, J & Bhatia, KP 2014, 'The role of the cerebellum in the pathogenesis of cortical myoclonus', MOVEMENT DISORD, vol. 29, no. 4, pp. 437-43. https://doi.org/10.1002/mds.25867

APA

Ganos, C., Kassavetis, P., Erro, R., Edwards, M. J., Rothwell, J., & Bhatia, K. P. (2014). The role of the cerebellum in the pathogenesis of cortical myoclonus. MOVEMENT DISORD, 29(4), 437-43. https://doi.org/10.1002/mds.25867

Vancouver

Ganos C, Kassavetis P, Erro R, Edwards MJ, Rothwell J, Bhatia KP. The role of the cerebellum in the pathogenesis of cortical myoclonus. MOVEMENT DISORD. 2014 Apr 1;29(4):437-43. https://doi.org/10.1002/mds.25867

Bibtex

@article{c1f07984d2044518aff137e2678bc8db,
title = "The role of the cerebellum in the pathogenesis of cortical myoclonus",
abstract = "The putative involvement of the cerebellum in the pathogenesis of cortical myoclonic syndromes has been long hypothesized, as neuropathological changes in patients with cortical myoclonus have most commonly been found in the cerebellum rather than in the suspected culprit, the primary somatosensory cortex. A model of increased cortical excitability due to loss of cerebellar inhibitory control via cerebello-thalamo-cortical connections has been proposed, but evidence remains equivocal. Here, we explore this hypothesis by examining syndromes that present with cortical myoclonus and ataxia. We first describe common clinical characteristics and underlying neuropathology. We critically view information on cerebellar physiology with regard to motorcortical output and compare findings between hypothesized and reported neurophysiological changes in conditions with cortical myoclonus and ataxia. We synthesize knowledge and focus on neurochemical changes in these conditions. Finally, we propose that the combination of alterations in inhibitory neurotransmission and the presence of cerebellar pathology are important elements in the pathogenesis of cortical myoclonus.",
keywords = "Ataxia, Cerebellum, Cerebral Cortex, Electroencephalography, Humans, Myoclonus, Synaptic Transmission",
author = "Christos Ganos and Panagiotis Kassavetis and Roberto Erro and Edwards, {Mark J} and John Rothwell and Bhatia, {Kailash P}",
note = "{\textcopyright} 2014 International Parkinson and Movement Disorder Society.",
year = "2014",
month = apr,
day = "1",
doi = "10.1002/mds.25867",
language = "English",
volume = "29",
pages = "437--43",
journal = "MOVEMENT DISORD",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - The role of the cerebellum in the pathogenesis of cortical myoclonus

AU - Ganos, Christos

AU - Kassavetis, Panagiotis

AU - Erro, Roberto

AU - Edwards, Mark J

AU - Rothwell, John

AU - Bhatia, Kailash P

N1 - © 2014 International Parkinson and Movement Disorder Society.

PY - 2014/4/1

Y1 - 2014/4/1

N2 - The putative involvement of the cerebellum in the pathogenesis of cortical myoclonic syndromes has been long hypothesized, as neuropathological changes in patients with cortical myoclonus have most commonly been found in the cerebellum rather than in the suspected culprit, the primary somatosensory cortex. A model of increased cortical excitability due to loss of cerebellar inhibitory control via cerebello-thalamo-cortical connections has been proposed, but evidence remains equivocal. Here, we explore this hypothesis by examining syndromes that present with cortical myoclonus and ataxia. We first describe common clinical characteristics and underlying neuropathology. We critically view information on cerebellar physiology with regard to motorcortical output and compare findings between hypothesized and reported neurophysiological changes in conditions with cortical myoclonus and ataxia. We synthesize knowledge and focus on neurochemical changes in these conditions. Finally, we propose that the combination of alterations in inhibitory neurotransmission and the presence of cerebellar pathology are important elements in the pathogenesis of cortical myoclonus.

AB - The putative involvement of the cerebellum in the pathogenesis of cortical myoclonic syndromes has been long hypothesized, as neuropathological changes in patients with cortical myoclonus have most commonly been found in the cerebellum rather than in the suspected culprit, the primary somatosensory cortex. A model of increased cortical excitability due to loss of cerebellar inhibitory control via cerebello-thalamo-cortical connections has been proposed, but evidence remains equivocal. Here, we explore this hypothesis by examining syndromes that present with cortical myoclonus and ataxia. We first describe common clinical characteristics and underlying neuropathology. We critically view information on cerebellar physiology with regard to motorcortical output and compare findings between hypothesized and reported neurophysiological changes in conditions with cortical myoclonus and ataxia. We synthesize knowledge and focus on neurochemical changes in these conditions. Finally, we propose that the combination of alterations in inhibitory neurotransmission and the presence of cerebellar pathology are important elements in the pathogenesis of cortical myoclonus.

KW - Ataxia

KW - Cerebellum

KW - Cerebral Cortex

KW - Electroencephalography

KW - Humans

KW - Myoclonus

KW - Synaptic Transmission

U2 - 10.1002/mds.25867

DO - 10.1002/mds.25867

M3 - SCORING: Journal article

C2 - 24634361

VL - 29

SP - 437

EP - 443

JO - MOVEMENT DISORD

JF - MOVEMENT DISORD

SN - 0885-3185

IS - 4

ER -