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The role of the cannabinoid receptor in adolescents' processing of facial expressions

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The role of the cannabinoid receptor in adolescents' processing of facial expressions. / Ewald, Anais; Becker, Susanne; Heinrich, Angela; Banaschewski, Tobias; Poustka, Luise; Bokde, Arun; Büchel, Christian; Bromberg, Uli; Cattrell, Anna; Conrod, Patricia; Desrivières, Sylvane; Frouin, Vincent; Papadopoulos-Orfanos, Dimitri; Gallinat, Jürgen; Garavan, Hugh; Heinz, Andreas; Walter, Henrik; Ittermann, Bernd; Gowland, Penny; Paus, Tomáš; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Smolka, Michael N; Vetter, Nora; Whelan, Rob; Schumann, Gunter; Flor, Herta; Nees, Frauke; IMAGEN Consortium.

In: EUR J NEUROSCI, Vol. 43, No. 1, 01.2016, p. 98-105.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ewald, A, Becker, S, Heinrich, A, Banaschewski, T, Poustka, L, Bokde, A, Büchel, C, Bromberg, U, Cattrell, A, Conrod, P, Desrivières, S, Frouin, V, Papadopoulos-Orfanos, D, Gallinat, J, Garavan, H, Heinz, A, Walter, H, Ittermann, B, Gowland, P, Paus, T, Martinot, J-L, Paillère Martinot, M-L, Smolka, MN, Vetter, N, Whelan, R, Schumann, G, Flor, H, Nees, F & IMAGEN Consortium 2016, 'The role of the cannabinoid receptor in adolescents' processing of facial expressions', EUR J NEUROSCI, vol. 43, no. 1, pp. 98-105. https://doi.org/10.1111/ejn.13118

APA

Ewald, A., Becker, S., Heinrich, A., Banaschewski, T., Poustka, L., Bokde, A., Büchel, C., Bromberg, U., Cattrell, A., Conrod, P., Desrivières, S., Frouin, V., Papadopoulos-Orfanos, D., Gallinat, J., Garavan, H., Heinz, A., Walter, H., Ittermann, B., Gowland, P., ... IMAGEN Consortium (2016). The role of the cannabinoid receptor in adolescents' processing of facial expressions. EUR J NEUROSCI, 43(1), 98-105. https://doi.org/10.1111/ejn.13118

Vancouver

Ewald A, Becker S, Heinrich A, Banaschewski T, Poustka L, Bokde A et al. The role of the cannabinoid receptor in adolescents' processing of facial expressions. EUR J NEUROSCI. 2016 Jan;43(1):98-105. https://doi.org/10.1111/ejn.13118

Bibtex

@article{c76aad0ebaa440ee8d484bb3ad14e77c,
title = "The role of the cannabinoid receptor in adolescents' processing of facial expressions",
abstract = "The processing of emotional faces is an important prerequisite for adequate social interactions in daily life, and might thus specifically be altered in adolescence, a period marked by significant changes in social emotional processing. Previous research has shown that the cannabinoid receptor CB1R is associated with longer gaze duration and increased brain responses in the striatum to happy faces in adults, yet, for adolescents, it is not clear whether an association between CBR1 and face processing exists. In the present study we investigated genetic effects of the two CB1R polymorphisms, rs1049353 and rs806377, on the processing of emotional faces in healthy adolescents. They participated in functional magnetic resonance imaging during a Faces Task, watching blocks of video clips with angry and neutral facial expressions, and completed a Morphed Faces Task in the laboratory where they looked at different facial expressions that switched from anger to fear or sadness or from happiness to fear or sadness, and labelled them according to these four emotional expressions. A-allele versus GG-carriers in rs1049353 displayed earlier recognition of facial expressions changing from anger to sadness or fear, but not for expressions changing from happiness to sadness or fear, and higher brain responses to angry, but not neutral, faces in the amygdala and insula. For rs806377 no significant effects emerged. This suggests that rs1049353 is involved in the processing of negative facial expressions with relation to anger in adolescence. These findings add to our understanding of social emotion-related mechanisms in this life period.",
author = "Anais Ewald and Susanne Becker and Angela Heinrich and Tobias Banaschewski and Luise Poustka and Arun Bokde and Christian B{\"u}chel and Uli Bromberg and Anna Cattrell and Patricia Conrod and Sylvane Desrivi{\`e}res and Vincent Frouin and Dimitri Papadopoulos-Orfanos and J{\"u}rgen Gallinat and Hugh Garavan and Andreas Heinz and Henrik Walter and Bernd Ittermann and Penny Gowland and Tom{\'a}{\v s} Paus and Jean-Luc Martinot and {Paill{\`e}re Martinot}, Marie-Laure and Smolka, {Michael N} and Nora Vetter and Rob Whelan and Gunter Schumann and Herta Flor and Frauke Nees and {IMAGEN Consortium}",
note = "{\textcopyright} 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.",
year = "2016",
month = jan,
doi = "10.1111/ejn.13118",
language = "English",
volume = "43",
pages = "98--105",
journal = "EUR J NEUROSCI",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - The role of the cannabinoid receptor in adolescents' processing of facial expressions

AU - Ewald, Anais

AU - Becker, Susanne

AU - Heinrich, Angela

AU - Banaschewski, Tobias

AU - Poustka, Luise

AU - Bokde, Arun

AU - Büchel, Christian

AU - Bromberg, Uli

AU - Cattrell, Anna

AU - Conrod, Patricia

AU - Desrivières, Sylvane

AU - Frouin, Vincent

AU - Papadopoulos-Orfanos, Dimitri

AU - Gallinat, Jürgen

AU - Garavan, Hugh

AU - Heinz, Andreas

AU - Walter, Henrik

AU - Ittermann, Bernd

AU - Gowland, Penny

AU - Paus, Tomáš

AU - Martinot, Jean-Luc

AU - Paillère Martinot, Marie-Laure

AU - Smolka, Michael N

AU - Vetter, Nora

AU - Whelan, Rob

AU - Schumann, Gunter

AU - Flor, Herta

AU - Nees, Frauke

AU - IMAGEN Consortium

N1 - © 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

PY - 2016/1

Y1 - 2016/1

N2 - The processing of emotional faces is an important prerequisite for adequate social interactions in daily life, and might thus specifically be altered in adolescence, a period marked by significant changes in social emotional processing. Previous research has shown that the cannabinoid receptor CB1R is associated with longer gaze duration and increased brain responses in the striatum to happy faces in adults, yet, for adolescents, it is not clear whether an association between CBR1 and face processing exists. In the present study we investigated genetic effects of the two CB1R polymorphisms, rs1049353 and rs806377, on the processing of emotional faces in healthy adolescents. They participated in functional magnetic resonance imaging during a Faces Task, watching blocks of video clips with angry and neutral facial expressions, and completed a Morphed Faces Task in the laboratory where they looked at different facial expressions that switched from anger to fear or sadness or from happiness to fear or sadness, and labelled them according to these four emotional expressions. A-allele versus GG-carriers in rs1049353 displayed earlier recognition of facial expressions changing from anger to sadness or fear, but not for expressions changing from happiness to sadness or fear, and higher brain responses to angry, but not neutral, faces in the amygdala and insula. For rs806377 no significant effects emerged. This suggests that rs1049353 is involved in the processing of negative facial expressions with relation to anger in adolescence. These findings add to our understanding of social emotion-related mechanisms in this life period.

AB - The processing of emotional faces is an important prerequisite for adequate social interactions in daily life, and might thus specifically be altered in adolescence, a period marked by significant changes in social emotional processing. Previous research has shown that the cannabinoid receptor CB1R is associated with longer gaze duration and increased brain responses in the striatum to happy faces in adults, yet, for adolescents, it is not clear whether an association between CBR1 and face processing exists. In the present study we investigated genetic effects of the two CB1R polymorphisms, rs1049353 and rs806377, on the processing of emotional faces in healthy adolescents. They participated in functional magnetic resonance imaging during a Faces Task, watching blocks of video clips with angry and neutral facial expressions, and completed a Morphed Faces Task in the laboratory where they looked at different facial expressions that switched from anger to fear or sadness or from happiness to fear or sadness, and labelled them according to these four emotional expressions. A-allele versus GG-carriers in rs1049353 displayed earlier recognition of facial expressions changing from anger to sadness or fear, but not for expressions changing from happiness to sadness or fear, and higher brain responses to angry, but not neutral, faces in the amygdala and insula. For rs806377 no significant effects emerged. This suggests that rs1049353 is involved in the processing of negative facial expressions with relation to anger in adolescence. These findings add to our understanding of social emotion-related mechanisms in this life period.

U2 - 10.1111/ejn.13118

DO - 10.1111/ejn.13118

M3 - SCORING: Journal article

C2 - 26527537

VL - 43

SP - 98

EP - 105

JO - EUR J NEUROSCI

JF - EUR J NEUROSCI

SN - 0953-816X

IS - 1

ER -