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The role of surgery in Caroli's disease

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The role of surgery in Caroli's disease. / Bockhorn, Maximilian; Malagó, Massimo; Lang, Hauke; Nadalin, Silvio; Paul, Andreas; Saner, Fuat; Frilling, Andreja; Broelsch, Christoph E.

In: J AM COLL SURGEONS, Vol. 202, No. 6, 01.06.2006, p. 928-32.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bockhorn, M, Malagó, M, Lang, H, Nadalin, S, Paul, A, Saner, F, Frilling, A & Broelsch, CE 2006, 'The role of surgery in Caroli's disease', J AM COLL SURGEONS, vol. 202, no. 6, pp. 928-32. https://doi.org/10.1016/j.jamcollsurg.2006.02.021

APA

Bockhorn, M., Malagó, M., Lang, H., Nadalin, S., Paul, A., Saner, F., Frilling, A., & Broelsch, C. E. (2006). The role of surgery in Caroli's disease. J AM COLL SURGEONS, 202(6), 928-32. https://doi.org/10.1016/j.jamcollsurg.2006.02.021

Vancouver

Bockhorn M, Malagó M, Lang H, Nadalin S, Paul A, Saner F et al. The role of surgery in Caroli's disease. J AM COLL SURGEONS. 2006 Jun 1;202(6):928-32. https://doi.org/10.1016/j.jamcollsurg.2006.02.021

Bibtex

@article{309ffa180c024acabd88335dbbbf93f7,
title = "The role of surgery in Caroli's disease",
abstract = "BACKGROUND: Caroli's disease is a rare congenital disorder characterized by multifocal segmental dilation of the intrahepatic bile ducts. Whether conservative or surgical strategies should be preferred is still a matter of debate. The aim of this study was to evaluate the role of surgery in the management of Caroli's disease.STUDY DESIGN: From April 1998 until August 2005, 12 consecutive patients with Caroli's disease were treated in the Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Germany. All patients were intended to receive liver resections or liver transplantations.RESULTS: There were seven men and five women, with a median age of 39 years (range 7 months to 70 years). Eight patients had monolobar and four patients had bilobar liver involvement. All patients had a history of recurrent cholangitis, with up to 16 unsuccessful conservative treatment attempts. Nine patients (75%) underwent liver resection and two (17%) had liver transplantation. Intraoperatively, three patients (25%) were found to have cholangiocarcinoma, of which one was unresectable. There was no mortality and only low morbidity (16%) postoperatively. After a median followup of 31 months, 11 patients are well with no recurrent symptoms.CONCLUSIONS: Surgery can offer a definite therapy, with an acceptable morbidity and virtually no mortality in localized Caroli's disease. In diffuse disease, the use of extended resections or liver transplantation can provide good longterm results.",
keywords = "Adolescent, Adult, Aged, Caroli Disease, Child, Child, Preschool, Female, Follow-Up Studies, Germany, Hepatectomy, Humans, Incidence, Infant, Liver Transplantation, Male, Middle Aged, Postoperative Complications, Retrospective Studies, Survival Rate, Treatment Outcome",
author = "Maximilian Bockhorn and Massimo Malag{\'o} and Hauke Lang and Silvio Nadalin and Andreas Paul and Fuat Saner and Andreja Frilling and Broelsch, {Christoph E}",
year = "2006",
month = jun,
day = "1",
doi = "10.1016/j.jamcollsurg.2006.02.021",
language = "English",
volume = "202",
pages = "928--32",
journal = "J AM COLL SURGEONS",
issn = "1072-7515",
publisher = "Elsevier Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - The role of surgery in Caroli's disease

AU - Bockhorn, Maximilian

AU - Malagó, Massimo

AU - Lang, Hauke

AU - Nadalin, Silvio

AU - Paul, Andreas

AU - Saner, Fuat

AU - Frilling, Andreja

AU - Broelsch, Christoph E

PY - 2006/6/1

Y1 - 2006/6/1

N2 - BACKGROUND: Caroli's disease is a rare congenital disorder characterized by multifocal segmental dilation of the intrahepatic bile ducts. Whether conservative or surgical strategies should be preferred is still a matter of debate. The aim of this study was to evaluate the role of surgery in the management of Caroli's disease.STUDY DESIGN: From April 1998 until August 2005, 12 consecutive patients with Caroli's disease were treated in the Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Germany. All patients were intended to receive liver resections or liver transplantations.RESULTS: There were seven men and five women, with a median age of 39 years (range 7 months to 70 years). Eight patients had monolobar and four patients had bilobar liver involvement. All patients had a history of recurrent cholangitis, with up to 16 unsuccessful conservative treatment attempts. Nine patients (75%) underwent liver resection and two (17%) had liver transplantation. Intraoperatively, three patients (25%) were found to have cholangiocarcinoma, of which one was unresectable. There was no mortality and only low morbidity (16%) postoperatively. After a median followup of 31 months, 11 patients are well with no recurrent symptoms.CONCLUSIONS: Surgery can offer a definite therapy, with an acceptable morbidity and virtually no mortality in localized Caroli's disease. In diffuse disease, the use of extended resections or liver transplantation can provide good longterm results.

AB - BACKGROUND: Caroli's disease is a rare congenital disorder characterized by multifocal segmental dilation of the intrahepatic bile ducts. Whether conservative or surgical strategies should be preferred is still a matter of debate. The aim of this study was to evaluate the role of surgery in the management of Caroli's disease.STUDY DESIGN: From April 1998 until August 2005, 12 consecutive patients with Caroli's disease were treated in the Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Germany. All patients were intended to receive liver resections or liver transplantations.RESULTS: There were seven men and five women, with a median age of 39 years (range 7 months to 70 years). Eight patients had monolobar and four patients had bilobar liver involvement. All patients had a history of recurrent cholangitis, with up to 16 unsuccessful conservative treatment attempts. Nine patients (75%) underwent liver resection and two (17%) had liver transplantation. Intraoperatively, three patients (25%) were found to have cholangiocarcinoma, of which one was unresectable. There was no mortality and only low morbidity (16%) postoperatively. After a median followup of 31 months, 11 patients are well with no recurrent symptoms.CONCLUSIONS: Surgery can offer a definite therapy, with an acceptable morbidity and virtually no mortality in localized Caroli's disease. In diffuse disease, the use of extended resections or liver transplantation can provide good longterm results.

KW - Adolescent

KW - Adult

KW - Aged

KW - Caroli Disease

KW - Child

KW - Child, Preschool

KW - Female

KW - Follow-Up Studies

KW - Germany

KW - Hepatectomy

KW - Humans

KW - Incidence

KW - Infant

KW - Liver Transplantation

KW - Male

KW - Middle Aged

KW - Postoperative Complications

KW - Retrospective Studies

KW - Survival Rate

KW - Treatment Outcome

U2 - 10.1016/j.jamcollsurg.2006.02.021

DO - 10.1016/j.jamcollsurg.2006.02.021

M3 - SCORING: Journal article

C2 - 16735207

VL - 202

SP - 928

EP - 932

JO - J AM COLL SURGEONS

JF - J AM COLL SURGEONS

SN - 1072-7515

IS - 6

ER -