The Role of Renal Progenitors in Renal Regeneration
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The Role of Renal Progenitors in Renal Regeneration. / Meyer-Schwesinger, Catherine.
In: NEPHRON, Vol. 132, No. 2, 2016, p. 101-109.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The Role of Renal Progenitors in Renal Regeneration
AU - Meyer-Schwesinger, Catherine
N1 - © 2016 S. Karger AG, Basel.
PY - 2016
Y1 - 2016
N2 - The adult kidney has a remarkable ability to survive injury and restore function despite a limited turnover of cells under physiologic conditions. This accounts both for the tubular and to a lesser extent for the glomerular compartment. It is an ongoing debate whether renal repair is carried out by self-duplication/de-differentiation of mature resident renal cells, or by specialized renal progenitors residing in specific niches or by circulating bone marrow-derived stem cells. In this review, the existence of renal progenitor cells and their contribution for regeneration of the tubular and the glomerular compartment are discussed, highlighting landmark publications of recent years.
AB - The adult kidney has a remarkable ability to survive injury and restore function despite a limited turnover of cells under physiologic conditions. This accounts both for the tubular and to a lesser extent for the glomerular compartment. It is an ongoing debate whether renal repair is carried out by self-duplication/de-differentiation of mature resident renal cells, or by specialized renal progenitors residing in specific niches or by circulating bone marrow-derived stem cells. In this review, the existence of renal progenitor cells and their contribution for regeneration of the tubular and the glomerular compartment are discussed, highlighting landmark publications of recent years.
U2 - 10.1159/000442180
DO - 10.1159/000442180
M3 - SCORING: Journal article
C2 - 26771306
VL - 132
SP - 101
EP - 109
JO - NEPHRON
JF - NEPHRON
SN - 1660-8151
IS - 2
ER -