The Role of Renal Progenitors in Renal Regeneration

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The Role of Renal Progenitors in Renal Regeneration. / Meyer-Schwesinger, Catherine.

In: NEPHRON, Vol. 132, No. 2, 2016, p. 101-109.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

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@article{79d2d8eee1084945b647b5b83b74da70,
title = "The Role of Renal Progenitors in Renal Regeneration",
abstract = "The adult kidney has a remarkable ability to survive injury and restore function despite a limited turnover of cells under physiologic conditions. This accounts both for the tubular and to a lesser extent for the glomerular compartment. It is an ongoing debate whether renal repair is carried out by self-duplication/de-differentiation of mature resident renal cells, or by specialized renal progenitors residing in specific niches or by circulating bone marrow-derived stem cells. In this review, the existence of renal progenitor cells and their contribution for regeneration of the tubular and the glomerular compartment are discussed, highlighting landmark publications of recent years.",
author = "Catherine Meyer-Schwesinger",
note = "{\textcopyright} 2016 S. Karger AG, Basel.",
year = "2016",
doi = "10.1159/000442180",
language = "English",
volume = "132",
pages = "101--109",
journal = "NEPHRON",
issn = "1660-8151",
publisher = "S. Karger AG",
number = "2",

}

RIS

TY - JOUR

T1 - The Role of Renal Progenitors in Renal Regeneration

AU - Meyer-Schwesinger, Catherine

N1 - © 2016 S. Karger AG, Basel.

PY - 2016

Y1 - 2016

N2 - The adult kidney has a remarkable ability to survive injury and restore function despite a limited turnover of cells under physiologic conditions. This accounts both for the tubular and to a lesser extent for the glomerular compartment. It is an ongoing debate whether renal repair is carried out by self-duplication/de-differentiation of mature resident renal cells, or by specialized renal progenitors residing in specific niches or by circulating bone marrow-derived stem cells. In this review, the existence of renal progenitor cells and their contribution for regeneration of the tubular and the glomerular compartment are discussed, highlighting landmark publications of recent years.

AB - The adult kidney has a remarkable ability to survive injury and restore function despite a limited turnover of cells under physiologic conditions. This accounts both for the tubular and to a lesser extent for the glomerular compartment. It is an ongoing debate whether renal repair is carried out by self-duplication/de-differentiation of mature resident renal cells, or by specialized renal progenitors residing in specific niches or by circulating bone marrow-derived stem cells. In this review, the existence of renal progenitor cells and their contribution for regeneration of the tubular and the glomerular compartment are discussed, highlighting landmark publications of recent years.

U2 - 10.1159/000442180

DO - 10.1159/000442180

M3 - SCORING: Journal article

C2 - 26771306

VL - 132

SP - 101

EP - 109

JO - NEPHRON

JF - NEPHRON

SN - 1660-8151

IS - 2

ER -