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The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer

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The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer. / Quhal, Fahad; Rajwa, Pawel; Mori, Keiichiro; Laukhtina, Ekaterina; Grossmann, Nico C; Schuettfort, Victor M; König, Frederik; Aydh, Abdulmajeed; Motlagh, Reza S; Katayama, Satoshi; Mostafai, Hadi; Pradere, Benjamin; Marra, Giancarlo; Gontero, Paolo; Mathieu, Romain; Karakiewicz, Pierre I; Briganti, Alberto; Shariat, Shahrokh F; Heidenreich, Axel.

In: PROSTATE, Vol. 81, No. 11, 08.2021, p. 765-771.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Quhal, F, Rajwa, P, Mori, K, Laukhtina, E, Grossmann, NC, Schuettfort, VM, König, F, Aydh, A, Motlagh, RS, Katayama, S, Mostafai, H, Pradere, B, Marra, G, Gontero, P, Mathieu, R, Karakiewicz, PI, Briganti, A, Shariat, SF & Heidenreich, A 2021, 'The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer', PROSTATE, vol. 81, no. 11, pp. 765-771. https://doi.org/10.1002/pros.24173

APA

Quhal, F., Rajwa, P., Mori, K., Laukhtina, E., Grossmann, N. C., Schuettfort, V. M., König, F., Aydh, A., Motlagh, R. S., Katayama, S., Mostafai, H., Pradere, B., Marra, G., Gontero, P., Mathieu, R., Karakiewicz, P. I., Briganti, A., Shariat, S. F., & Heidenreich, A. (2021). The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer. PROSTATE, 81(11), 765-771. https://doi.org/10.1002/pros.24173

Vancouver

Quhal F, Rajwa P, Mori K, Laukhtina E, Grossmann NC, Schuettfort VM et al. The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer. PROSTATE. 2021 Aug;81(11):765-771. https://doi.org/10.1002/pros.24173

Bibtex

@article{5f9c634339d34412b96a847a98bd24f7,
title = "The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer",
abstract = "PURPOSE: To examine the effect of lymph node dissection on the outcomes of patients who underwent salvage radical prostatectomy (SRP).MATERIAL AND METHODS: We retrospectively reviewed data from radiation-recurrent patients with prostate cancer (PCa) who underwent SRP from 2000-2016. None of the patients had clinical lymph node involvement before SRP. The effect of the number of removed lymph nodes (RLNs) and the number of positive lymph nodes (PLNs) on biochemical recurrence (BCR)-free survival, metastases free survival, and overall survival (OS) was tested in multivariable Cox regression analyses.RESULTS: About 334 patients underwent SRP and pelvic lymph node dissection (PLND). Lymph node involvement was associated with increased risk of BCR (p < .001), metastasis (p < .001), and overall mortality (p = .006). In a multivariable Cox regression analysis, an increased number of RLNs significantly lowered the risk of BCR (hazard ratio [HR] 0.96, p = .01). In patients with positive lymph nodes, a higher number of RLNs and a lower number of PLNs were associated with improved freedom from BCR (HR 0.89, p = .001 and HR 1.34, p = .008, respectively). At a median follow-up of 23.9 months (interquartile range, 4.7-37.7), neither the number of RLNs nor the number of PLNs were associated with OS (p = .69 and p = .34, respectively).CONCLUSION: Pathologic lymph node involvement increased the risk of BCR, metastasis and overall mortality in radiation-recurrent PCa patients undergoing SRP. The risk of BCR decreased steadily with a higher number of RLNs during SRP. Further research is needed to support this conclusion and develop a precise therapeutic adjuvant strategy based on the number of RLNs and PLNs.",
author = "Fahad Quhal and Pawel Rajwa and Keiichiro Mori and Ekaterina Laukhtina and Grossmann, {Nico C} and Schuettfort, {Victor M} and Frederik K{\"o}nig and Abdulmajeed Aydh and Motlagh, {Reza S} and Satoshi Katayama and Hadi Mostafai and Benjamin Pradere and Giancarlo Marra and Paolo Gontero and Romain Mathieu and Karakiewicz, {Pierre I} and Alberto Briganti and Shariat, {Shahrokh F} and Axel Heidenreich",
note = "{\textcopyright} 2021 The Authors. The Prostate published by Wiley Periodicals LLC.",
year = "2021",
month = aug,
doi = "10.1002/pros.24173",
language = "English",
volume = "81",
pages = "765--771",
journal = "PROSTATE",
issn = "0270-4137",
publisher = "Wiley-Liss Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer

AU - Quhal, Fahad

AU - Rajwa, Pawel

AU - Mori, Keiichiro

AU - Laukhtina, Ekaterina

AU - Grossmann, Nico C

AU - Schuettfort, Victor M

AU - König, Frederik

AU - Aydh, Abdulmajeed

AU - Motlagh, Reza S

AU - Katayama, Satoshi

AU - Mostafai, Hadi

AU - Pradere, Benjamin

AU - Marra, Giancarlo

AU - Gontero, Paolo

AU - Mathieu, Romain

AU - Karakiewicz, Pierre I

AU - Briganti, Alberto

AU - Shariat, Shahrokh F

AU - Heidenreich, Axel

N1 - © 2021 The Authors. The Prostate published by Wiley Periodicals LLC.

PY - 2021/8

Y1 - 2021/8

N2 - PURPOSE: To examine the effect of lymph node dissection on the outcomes of patients who underwent salvage radical prostatectomy (SRP).MATERIAL AND METHODS: We retrospectively reviewed data from radiation-recurrent patients with prostate cancer (PCa) who underwent SRP from 2000-2016. None of the patients had clinical lymph node involvement before SRP. The effect of the number of removed lymph nodes (RLNs) and the number of positive lymph nodes (PLNs) on biochemical recurrence (BCR)-free survival, metastases free survival, and overall survival (OS) was tested in multivariable Cox regression analyses.RESULTS: About 334 patients underwent SRP and pelvic lymph node dissection (PLND). Lymph node involvement was associated with increased risk of BCR (p < .001), metastasis (p < .001), and overall mortality (p = .006). In a multivariable Cox regression analysis, an increased number of RLNs significantly lowered the risk of BCR (hazard ratio [HR] 0.96, p = .01). In patients with positive lymph nodes, a higher number of RLNs and a lower number of PLNs were associated with improved freedom from BCR (HR 0.89, p = .001 and HR 1.34, p = .008, respectively). At a median follow-up of 23.9 months (interquartile range, 4.7-37.7), neither the number of RLNs nor the number of PLNs were associated with OS (p = .69 and p = .34, respectively).CONCLUSION: Pathologic lymph node involvement increased the risk of BCR, metastasis and overall mortality in radiation-recurrent PCa patients undergoing SRP. The risk of BCR decreased steadily with a higher number of RLNs during SRP. Further research is needed to support this conclusion and develop a precise therapeutic adjuvant strategy based on the number of RLNs and PLNs.

AB - PURPOSE: To examine the effect of lymph node dissection on the outcomes of patients who underwent salvage radical prostatectomy (SRP).MATERIAL AND METHODS: We retrospectively reviewed data from radiation-recurrent patients with prostate cancer (PCa) who underwent SRP from 2000-2016. None of the patients had clinical lymph node involvement before SRP. The effect of the number of removed lymph nodes (RLNs) and the number of positive lymph nodes (PLNs) on biochemical recurrence (BCR)-free survival, metastases free survival, and overall survival (OS) was tested in multivariable Cox regression analyses.RESULTS: About 334 patients underwent SRP and pelvic lymph node dissection (PLND). Lymph node involvement was associated with increased risk of BCR (p < .001), metastasis (p < .001), and overall mortality (p = .006). In a multivariable Cox regression analysis, an increased number of RLNs significantly lowered the risk of BCR (hazard ratio [HR] 0.96, p = .01). In patients with positive lymph nodes, a higher number of RLNs and a lower number of PLNs were associated with improved freedom from BCR (HR 0.89, p = .001 and HR 1.34, p = .008, respectively). At a median follow-up of 23.9 months (interquartile range, 4.7-37.7), neither the number of RLNs nor the number of PLNs were associated with OS (p = .69 and p = .34, respectively).CONCLUSION: Pathologic lymph node involvement increased the risk of BCR, metastasis and overall mortality in radiation-recurrent PCa patients undergoing SRP. The risk of BCR decreased steadily with a higher number of RLNs during SRP. Further research is needed to support this conclusion and develop a precise therapeutic adjuvant strategy based on the number of RLNs and PLNs.

U2 - 10.1002/pros.24173

DO - 10.1002/pros.24173

M3 - SCORING: Journal article

C2 - 34057227

VL - 81

SP - 765

EP - 771

JO - PROSTATE

JF - PROSTATE

SN - 0270-4137

IS - 11

ER -