The role of decidual immune cells on human pregnancy
Standard
The role of decidual immune cells on human pregnancy. / Liu, Su; Diao, Liang-Hui; Huang, Chunyu; Li, Yuye; Zeng, Yong; Kwak-Kim, Joanne Y.H.
In: J REPROD IMMUNOL, Vol. 124, 11.2017, p. 44-53.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - The role of decidual immune cells on human pregnancy
AU - Liu, Su
AU - Diao, Liang-Hui
AU - Huang, Chunyu
AU - Li, Yuye
AU - Zeng, Yong
AU - Kwak-Kim, Joanne Y.H
PY - 2017/11
Y1 - 2017/11
N2 - The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and develop in the uterus, despite being recognized by the maternal immune cells. Within the innate immune system, decidual natural killer cells and antigen presenting cells (including macrophages and dendritic cells) that comprise a large proportion of the decidual leukocyte populations play an important role in modulating trophoblast invasion, angiogenesis and vascular remodeling. On the other hand, within the adaptive immune system, CD8+ T cells, effector CD4+ T cells, Foxp3+ regulatory T cells and CD4+HLA-G+ suppressor T cells are identified as potential players in maintaining immune tolerance toward the semi-allogeneic fetus. This review discusses how these key immune cells contribute to pregnancy outcome and the complex interactions between the innate and adaptive immune system during human pregnancy.
AB - The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and develop in the uterus, despite being recognized by the maternal immune cells. Within the innate immune system, decidual natural killer cells and antigen presenting cells (including macrophages and dendritic cells) that comprise a large proportion of the decidual leukocyte populations play an important role in modulating trophoblast invasion, angiogenesis and vascular remodeling. On the other hand, within the adaptive immune system, CD8+ T cells, effector CD4+ T cells, Foxp3+ regulatory T cells and CD4+HLA-G+ suppressor T cells are identified as potential players in maintaining immune tolerance toward the semi-allogeneic fetus. This review discusses how these key immune cells contribute to pregnancy outcome and the complex interactions between the innate and adaptive immune system during human pregnancy.
U2 - 10.1016/j.jri.2017.10.045
DO - 10.1016/j.jri.2017.10.045
M3 - SCORING: Review article
VL - 124
SP - 44
EP - 53
JO - J REPROD IMMUNOL
JF - J REPROD IMMUNOL
SN - 0165-0378
ER -