The role of complement in arterial hypertension and hypertensive end organ damage
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The role of complement in arterial hypertension and hypertensive end organ damage. / Wenzel, Ulrich O; Kemper, Claudia; Bode, Marlies.
In: BRIT J PHARMACOL, Vol. 178, No. 14, 07.2021, p. 2849-2862.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - The role of complement in arterial hypertension and hypertensive end organ damage
AU - Wenzel, Ulrich O
AU - Kemper, Claudia
AU - Bode, Marlies
N1 - © 2020 The British Pharmacological Society.
PY - 2021/7
Y1 - 2021/7
N2 - Increasing evidence indicates that hypertension and hypertensive end organ damage are not only mediated by haemodynamic injury but that inflammation also plays an important role. The complement system protects the host from a hostile microbial environment and maintains tissue and cell integrity through the elimination of altered or dead cells. As an important effector arm of innate immunity, it plays also central roles in the regulation of adaptive immunity. Thus, complement activation may drive the pathology of hypertension through its effects on innate and adaptive immune responses, aside from direct effects on the vasculature. Recent experimental data strongly support a role for complement in all stages of arterial hypertension. The remarkably similar clinical and histopathological features of malignant nephrosclerosis and atypical haemolytic uraemic syndrome suggest also a role for complement in the development of malignant nephrosclerosis. Here, we review the role of complement in hypertension and hypertensive end organ damage. LINKED ARTICLES: This article is part of a themed issue on Canonical and non-canonical functions of the complement system in health and disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.14/issuetoc.
AB - Increasing evidence indicates that hypertension and hypertensive end organ damage are not only mediated by haemodynamic injury but that inflammation also plays an important role. The complement system protects the host from a hostile microbial environment and maintains tissue and cell integrity through the elimination of altered or dead cells. As an important effector arm of innate immunity, it plays also central roles in the regulation of adaptive immunity. Thus, complement activation may drive the pathology of hypertension through its effects on innate and adaptive immune responses, aside from direct effects on the vasculature. Recent experimental data strongly support a role for complement in all stages of arterial hypertension. The remarkably similar clinical and histopathological features of malignant nephrosclerosis and atypical haemolytic uraemic syndrome suggest also a role for complement in the development of malignant nephrosclerosis. Here, we review the role of complement in hypertension and hypertensive end organ damage. LINKED ARTICLES: This article is part of a themed issue on Canonical and non-canonical functions of the complement system in health and disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.14/issuetoc.
KW - Adaptive Immunity
KW - Complement System Proteins
KW - Humans
KW - Hypertension
KW - Immunity, Innate
KW - Inflammation
U2 - 10.1111/bph.15171
DO - 10.1111/bph.15171
M3 - SCORING: Review article
C2 - 32585035
VL - 178
SP - 2849
EP - 2862
JO - BRIT J PHARMACOL
JF - BRIT J PHARMACOL
SN - 0007-1188
IS - 14
ER -
