The role of calcitonin and alpha-calcitonin gene-related peptide in bone formation.
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The role of calcitonin and alpha-calcitonin gene-related peptide in bone formation. / Hübner, Antje K.; Keller, Johannes; Catalá-Lehnen, Philip; Perkovic, Sandra; Streichert, Thomas; Emeson, Ronald B; Amling, Michael; Schinke, Thorsten.
In: ARCH BIOCHEM BIOPHYS, Vol. 473, No. 2, 2, 2008, p. 210-217.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The role of calcitonin and alpha-calcitonin gene-related peptide in bone formation.
AU - Hübner, Antje K.
AU - Keller, Johannes
AU - Catalá-Lehnen, Philip
AU - Perkovic, Sandra
AU - Streichert, Thomas
AU - Emeson, Ronald B
AU - Amling, Michael
AU - Schinke, Thorsten
PY - 2008
Y1 - 2008
N2 - The Calca gene encodes two polypeptides, calcitonin (CT) and alpha-calcitonin gene-related peptide (alpha-CGRP), generated through alternative splicing. While CT, a hormone mainly produced by thyroidal C cells, has been described as a major regulator of bone resorption, alpha-CGRP, a neuropeptide expressed in the cells of the central and peripheral nervous system, is mostly known as a regulator of vascular tone. Surprisingly, the generation and skeletal analyses of two mouse deficiency models has recently uncovered a physiological function for both peptides in the regulation of bone formation. In the first model, where the replacement of exons 2-5 of the Calca gene resulted in the combined deficiency of CT and alpha-CGRP, an increased bone formation rate (BFR) was observed, whereas decreased BFR was found in the second model, where the introduction of a translational termination codon into exon 5 of the Calca gene resulted in the specific absence of alpha-CGRP.
AB - The Calca gene encodes two polypeptides, calcitonin (CT) and alpha-calcitonin gene-related peptide (alpha-CGRP), generated through alternative splicing. While CT, a hormone mainly produced by thyroidal C cells, has been described as a major regulator of bone resorption, alpha-CGRP, a neuropeptide expressed in the cells of the central and peripheral nervous system, is mostly known as a regulator of vascular tone. Surprisingly, the generation and skeletal analyses of two mouse deficiency models has recently uncovered a physiological function for both peptides in the regulation of bone formation. In the first model, where the replacement of exons 2-5 of the Calca gene resulted in the combined deficiency of CT and alpha-CGRP, an increased bone formation rate (BFR) was observed, whereas decreased BFR was found in the second model, where the introduction of a translational termination codon into exon 5 of the Calca gene resulted in the specific absence of alpha-CGRP.
M3 - SCORING: Zeitschriftenaufsatz
VL - 473
SP - 210
EP - 217
JO - ARCH BIOCHEM BIOPHYS
JF - ARCH BIOCHEM BIOPHYS
SN - 0003-9861
IS - 2
M1 - 2
ER -
