The Relationship Between Alcohol Consumption, BMI, and Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis
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The Relationship Between Alcohol Consumption, BMI, and Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis. / Llamosas-Falcón, Laura; Rehm, Jürgen; Bright, Sophie; Buckley, Charlotte; Carr, Tessa; Kilian, Carolin; Lasserre, Aurélie M; Lemp, Julia M; Zhu, Yachen; Probst, Charlotte.
In: DIABETES CARE, Vol. 46, No. 11, 01.11.2023, p. 2076-2083.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - The Relationship Between Alcohol Consumption, BMI, and Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis
AU - Llamosas-Falcón, Laura
AU - Rehm, Jürgen
AU - Bright, Sophie
AU - Buckley, Charlotte
AU - Carr, Tessa
AU - Kilian, Carolin
AU - Lasserre, Aurélie M
AU - Lemp, Julia M
AU - Zhu, Yachen
AU - Probst, Charlotte
N1 - © 2023 by the American Diabetes Association.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - BACKGROUND: Moderate alcohol use may be associated with lower risk of type 2 diabetes mellitus (T2DM). Previous reviews have reached mixed conclusions.PURPOSE: To quantify the dose-response relationship between alcohol consumption and T2DM, accounting for differential effects by sex and BMI.DATA SOURCES: Medline, Embase, Web of Science, and one secondary data source.STUDY SELECTION: Cohort studies on the relationship between alcohol use and T2DM.DATA EXTRACTION: Fifty-five studies, and one secondary data source, were included with a combined sample size of 1,363,355 men and 1,290,628 women, with 89,983 and 57,974 individuals, respectively, diagnosed with T2DM.DATA SYNTHESIS: Multivariate dose-response meta-analytic random-effect models were used. For women, a J-shaped relationship was found with a maximum risk reduction of 31% (relative risk [RR] 0.69, 95% CI 0.64-0.74) at an intake of 16 g of pure alcohol per day compared with lifetime abstainers. The protective association ceased above 49 g per day (RR 0.82, 95% CI 0.68-0.99). For men, no statistically significant relationship was identified. When results were stratified by BMI, the protective association was only found in overweight and obese women.LIMITATIONS: Our analysis relied on aggregate data. We included some articles that determined exposure and cases via self-report, and the studies did not account for temporal variations in alcohol use.CONCLUSIONS: The observed reduced risk seems to be specific to women in general and women with a BMI ≥25 kg/m2. Our findings allow for a more precise prediction of the sex-specific relationship between T2DM and alcohol use, as our results differ from those of previous studies.
AB - BACKGROUND: Moderate alcohol use may be associated with lower risk of type 2 diabetes mellitus (T2DM). Previous reviews have reached mixed conclusions.PURPOSE: To quantify the dose-response relationship between alcohol consumption and T2DM, accounting for differential effects by sex and BMI.DATA SOURCES: Medline, Embase, Web of Science, and one secondary data source.STUDY SELECTION: Cohort studies on the relationship between alcohol use and T2DM.DATA EXTRACTION: Fifty-five studies, and one secondary data source, were included with a combined sample size of 1,363,355 men and 1,290,628 women, with 89,983 and 57,974 individuals, respectively, diagnosed with T2DM.DATA SYNTHESIS: Multivariate dose-response meta-analytic random-effect models were used. For women, a J-shaped relationship was found with a maximum risk reduction of 31% (relative risk [RR] 0.69, 95% CI 0.64-0.74) at an intake of 16 g of pure alcohol per day compared with lifetime abstainers. The protective association ceased above 49 g per day (RR 0.82, 95% CI 0.68-0.99). For men, no statistically significant relationship was identified. When results were stratified by BMI, the protective association was only found in overweight and obese women.LIMITATIONS: Our analysis relied on aggregate data. We included some articles that determined exposure and cases via self-report, and the studies did not account for temporal variations in alcohol use.CONCLUSIONS: The observed reduced risk seems to be specific to women in general and women with a BMI ≥25 kg/m2. Our findings allow for a more precise prediction of the sex-specific relationship between T2DM and alcohol use, as our results differ from those of previous studies.
KW - Male
KW - Humans
KW - Female
KW - Diabetes Mellitus, Type 2/epidemiology
KW - Risk Factors
KW - Body Mass Index
KW - Alcohol Drinking/adverse effects
KW - Cohort Studies
U2 - 10.2337/dc23-1015
DO - 10.2337/dc23-1015
M3 - SCORING: Review article
C2 - 37890103
VL - 46
SP - 2076
EP - 2083
JO - DIABETES CARE
JF - DIABETES CARE
SN - 0149-5992
IS - 11
ER -