Research ExplorerPublicationsThe relationship between adipokines and the onset of type 2 ...

The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

Standard

The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study. / Neville, Charlotte E; Patterson, Christopher C; Linden, Gerard J; Love, Karl; McKinley, Michelle C; Kee, Frank; Blankenberg, Stefan; Evans, Alun; Yarnell, John; Woodside, Jayne V.

In: DIABETES RES CLIN PR, Vol. 120, 10.2016, p. 24-30.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Neville, CE, Patterson, CC, Linden, GJ, Love, K, McKinley, MC, Kee, F, Blankenberg, S, Evans, A, Yarnell, J & Woodside, JV 2016, 'The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study', DIABETES RES CLIN PR, vol. 120, pp. 24-30. https://doi.org/10.1016/j.diabres.2016.07.010

APA

Neville, C. E., Patterson, C. C., Linden, G. J., Love, K., McKinley, M. C., Kee, F., Blankenberg, S., Evans, A., Yarnell, J., & Woodside, J. V. (2016). The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study. DIABETES RES CLIN PR, 120, 24-30. https://doi.org/10.1016/j.diabres.2016.07.010

Vancouver

Neville CE, Patterson CC, Linden GJ, Love K, McKinley MC, Kee F et al. The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study. DIABETES RES CLIN PR. 2016 Oct;120:24-30. https://doi.org/10.1016/j.diabres.2016.07.010

Bibtex

@article{17d86aeb6b264339ba3948f4321e78b6,
title = "The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study",
abstract = "AIMS: Epidemiological evidence suggests that adipokines may be associated with the onset of type 2 diabetes, but the evidence to date is limited and inconclusive. This study examined the association between adiponectin and leptin and the subsequent diagnosis of type 2 diabetes in a UK population based cohort of non-diabetic middle-aged men.METHODS: Baseline serum levels of leptin and adiponectin were measured in 1839 non-diabetic men aged 50-60years who were participating in the prospective population-based PRIME study. Over a mean follow-up of 14.7years, new cases of type 2 diabetes were determined from self-reported clinical information with subsequent validation by general practitioners.RESULTS: 151 Participants developed type 2 diabetes during follow-up. In Cox regression models adjusted for age, men in the top third of the leptin distribution were at increased risk (hazard ratio (HR) 4.27, 95% CI 2.67-6.83) and men in the top third of the adiponectin distribution at reduced risk (HR 0.24, 95% CI 0.14-0.42) relative to men in the bottom third. However, significance was lost for leptin after additional adjustment for BMI, waist to hip ratio, lifestyle factors and biological risk factors, including C-reactive protein (CRP). Further adjustment for HOMA-IR also resulted in loss of significance for adiponectin.CONCLUSIONS: This study provides evidence that adipokines are associated with men's future type 2 diabetes risk but not independently of other risk factors.",
keywords = "Adiponectin/blood, Biomarkers/blood, C-Reactive Protein/metabolism, Diabetes Mellitus, Type 2/blood, Humans, Incidence, Leptin/blood, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Risk Factors, United Kingdom/epidemiology",
author = "Neville, {Charlotte E} and Patterson, {Christopher C} and Linden, {Gerard J} and Karl Love and McKinley, {Michelle C} and Frank Kee and Stefan Blankenberg and Alun Evans and John Yarnell and Woodside, {Jayne V}",
note = "Crown Copyright {\textcopyright} 2016. Published by Elsevier Ireland Ltd. All rights reserved.",
year = "2016",
month = oct,
doi = "10.1016/j.diabres.2016.07.010",
language = "English",
volume = "120",
pages = "24--30",
journal = "DIABETES RES CLIN PR",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

AU - Neville, Charlotte E

AU - Patterson, Christopher C

AU - Linden, Gerard J

AU - Love, Karl

AU - McKinley, Michelle C

AU - Kee, Frank

AU - Blankenberg, Stefan

AU - Evans, Alun

AU - Yarnell, John

AU - Woodside, Jayne V

N1 - Crown Copyright © 2016. Published by Elsevier Ireland Ltd. All rights reserved.

PY - 2016/10

Y1 - 2016/10

N2 - AIMS: Epidemiological evidence suggests that adipokines may be associated with the onset of type 2 diabetes, but the evidence to date is limited and inconclusive. This study examined the association between adiponectin and leptin and the subsequent diagnosis of type 2 diabetes in a UK population based cohort of non-diabetic middle-aged men.METHODS: Baseline serum levels of leptin and adiponectin were measured in 1839 non-diabetic men aged 50-60years who were participating in the prospective population-based PRIME study. Over a mean follow-up of 14.7years, new cases of type 2 diabetes were determined from self-reported clinical information with subsequent validation by general practitioners.RESULTS: 151 Participants developed type 2 diabetes during follow-up. In Cox regression models adjusted for age, men in the top third of the leptin distribution were at increased risk (hazard ratio (HR) 4.27, 95% CI 2.67-6.83) and men in the top third of the adiponectin distribution at reduced risk (HR 0.24, 95% CI 0.14-0.42) relative to men in the bottom third. However, significance was lost for leptin after additional adjustment for BMI, waist to hip ratio, lifestyle factors and biological risk factors, including C-reactive protein (CRP). Further adjustment for HOMA-IR also resulted in loss of significance for adiponectin.CONCLUSIONS: This study provides evidence that adipokines are associated with men's future type 2 diabetes risk but not independently of other risk factors.

AB - AIMS: Epidemiological evidence suggests that adipokines may be associated with the onset of type 2 diabetes, but the evidence to date is limited and inconclusive. This study examined the association between adiponectin and leptin and the subsequent diagnosis of type 2 diabetes in a UK population based cohort of non-diabetic middle-aged men.METHODS: Baseline serum levels of leptin and adiponectin were measured in 1839 non-diabetic men aged 50-60years who were participating in the prospective population-based PRIME study. Over a mean follow-up of 14.7years, new cases of type 2 diabetes were determined from self-reported clinical information with subsequent validation by general practitioners.RESULTS: 151 Participants developed type 2 diabetes during follow-up. In Cox regression models adjusted for age, men in the top third of the leptin distribution were at increased risk (hazard ratio (HR) 4.27, 95% CI 2.67-6.83) and men in the top third of the adiponectin distribution at reduced risk (HR 0.24, 95% CI 0.14-0.42) relative to men in the bottom third. However, significance was lost for leptin after additional adjustment for BMI, waist to hip ratio, lifestyle factors and biological risk factors, including C-reactive protein (CRP). Further adjustment for HOMA-IR also resulted in loss of significance for adiponectin.CONCLUSIONS: This study provides evidence that adipokines are associated with men's future type 2 diabetes risk but not independently of other risk factors.

KW - Adiponectin/blood

KW - Biomarkers/blood

KW - C-Reactive Protein/metabolism

KW - Diabetes Mellitus, Type 2/blood

KW - Humans

KW - Incidence

KW - Leptin/blood

KW - Male

KW - Middle Aged

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Factors

KW - United Kingdom/epidemiology

U2 - 10.1016/j.diabres.2016.07.010

DO - 10.1016/j.diabres.2016.07.010

M3 - SCORING: Journal article

C2 - 27500548

VL - 120

SP - 24

EP - 30

JO - DIABETES RES CLIN PR

JF - DIABETES RES CLIN PR

SN - 0168-8227

ER -