The rate of secondary malignancies after radical prostatectomy versus external beam radiation therapy for localized prostate cancer: a population-based study on 17,845 patients.
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The rate of secondary malignancies after radical prostatectomy versus external beam radiation therapy for localized prostate cancer: a population-based study on 17,845 patients. / Bhojani, Naeem; Capitanio, Umberto; Nazareno, Suardi; Jeldres, Claudio; Isbarn, Hendrik; Shariat, Shahrokh F; Graefen, Markus; Arjane, Philippe; Duclos, Alain; Lattouf, Jean-Baptiste; Saad, Fred; Valiquette, Luc; Montorsi, Francesco; Perrotte, Paul; Karakiewicz, Pierre I.
In: INT J RADIAT ONCOL, Vol. 76, No. 2, 2, 2010, p. 342-348.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The rate of secondary malignancies after radical prostatectomy versus external beam radiation therapy for localized prostate cancer: a population-based study on 17,845 patients.
AU - Bhojani, Naeem
AU - Capitanio, Umberto
AU - Nazareno, Suardi
AU - Jeldres, Claudio
AU - Isbarn, Hendrik
AU - Shariat, Shahrokh F
AU - Graefen, Markus
AU - Arjane, Philippe
AU - Duclos, Alain
AU - Lattouf, Jean-Baptiste
AU - Saad, Fred
AU - Valiquette, Luc
AU - Montorsi, Francesco
AU - Perrotte, Paul
AU - Karakiewicz, Pierre I
PY - 2010
Y1 - 2010
N2 - PURPOSE: External-beam radiation therapy (EBRT) may predispose to secondary malignancies that include bladder cancer (BCa), rectal cancer (RCa), and lung cancer (LCa). We tested this hypothesis in a large French Canadian population-based cohort of prostate cancer patients. METHODS AND MATERIALS: Overall, 8,455 radical prostatectomy (RP) and 9,390 EBRT patients treated between 1983 and 2003 were assessed with Kaplan-Meier and Cox regression analyses. Three endpoints were examined: (1) diagnosis of secondary BCa, (2) LCa, or (3) RCa. Covariates included age, Charlson comorbidity index, and year of treatment. RESULTS: In multivariable analyses that relied on incident cases diagnosed 60 months or later after RP or EBRT, the rates of BCa (hazard ratio [HR], 1.4; p = 0.02), LCa (HR, 2.0; p = 0.004), and RCa (HR 2.1; p
AB - PURPOSE: External-beam radiation therapy (EBRT) may predispose to secondary malignancies that include bladder cancer (BCa), rectal cancer (RCa), and lung cancer (LCa). We tested this hypothesis in a large French Canadian population-based cohort of prostate cancer patients. METHODS AND MATERIALS: Overall, 8,455 radical prostatectomy (RP) and 9,390 EBRT patients treated between 1983 and 2003 were assessed with Kaplan-Meier and Cox regression analyses. Three endpoints were examined: (1) diagnosis of secondary BCa, (2) LCa, or (3) RCa. Covariates included age, Charlson comorbidity index, and year of treatment. RESULTS: In multivariable analyses that relied on incident cases diagnosed 60 months or later after RP or EBRT, the rates of BCa (hazard ratio [HR], 1.4; p = 0.02), LCa (HR, 2.0; p = 0.004), and RCa (HR 2.1; p
M3 - SCORING: Zeitschriftenaufsatz
VL - 76
SP - 342
EP - 348
JO - INT J RADIAT ONCOL
JF - INT J RADIAT ONCOL
SN - 0360-3016
IS - 2
M1 - 2
ER -