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The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata.

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The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata. / Betz, R C; König, K; Flaquer, A; Redler, S; Eigelshoven, S; Kortüm, Anne-Katrin; Hanneken, S; Hillmer, A; Tüting, T; Lambert, J; De Weert, J; Kruse, R; Lutz, G; Blaumeiser, B; Nöthen, M M.

In: BRIT J DERMATOL, Vol. 158, No. 2, 2, 2008, p. 389-391.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Betz, RC, König, K, Flaquer, A, Redler, S, Eigelshoven, S, Kortüm, A-K, Hanneken, S, Hillmer, A, Tüting, T, Lambert, J, De Weert, J, Kruse, R, Lutz, G, Blaumeiser, B & Nöthen, MM 2008, 'The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata.', BRIT J DERMATOL, vol. 158, no. 2, 2, pp. 389-391. <http://www.ncbi.nlm.nih.gov/pubmed/18028494?dopt=Citation>

APA

Betz, R. C., König, K., Flaquer, A., Redler, S., Eigelshoven, S., Kortüm, A-K., Hanneken, S., Hillmer, A., Tüting, T., Lambert, J., De Weert, J., Kruse, R., Lutz, G., Blaumeiser, B., & Nöthen, M. M. (2008). The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata. BRIT J DERMATOL, 158(2), 389-391. [2]. http://www.ncbi.nlm.nih.gov/pubmed/18028494?dopt=Citation

Vancouver

Betz RC, König K, Flaquer A, Redler S, Eigelshoven S, Kortüm A-K et al. The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata. BRIT J DERMATOL. 2008;158(2):389-391. 2.

Bibtex

@article{2740c32edf8645498a28412ace6e05a3,
title = "The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata.",
abstract = "BACKGROUND: The functional R620W (c.1858C>T) variant of the protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) has been associated with a variety of autoimmune disorders. A recent study has suggested that R620W also contributes to the severe form of alopecia areata (AA). OBJECTIVES: We sought to replicate the finding of an association between PTPN22 and severe AA. In addition, we wanted to study the effect of PTPN22 on the general risk to develop AA and on other subtypes of AA (mild AA, early/late age at onset, positive/negative family history). METHODS: The R620W variant was genotyped in a large case-control sample of Belgian-German origin with 435 patients and 628 controls. RESULTS: Significant results were obtained for the overall collective of patients with AA (P=0.007). Subdividing the sample according to severity of AA, family history and age at onset, we detected lowest P-values for patients with the severe form of AA (Pcorr=0.036), with a positive family history (Pcorr=0.042) and with an age at onset",
author = "Betz, {R C} and K K{\"o}nig and A Flaquer and S Redler and S Eigelshoven and Anne-Katrin Kort{\"u}m and S Hanneken and A Hillmer and T T{\"u}ting and J Lambert and {De Weert}, J and R Kruse and G Lutz and B Blaumeiser and N{\"o}then, {M M}",
year = "2008",
language = "Deutsch",
volume = "158",
pages = "389--391",
journal = "BRIT J DERMATOL",
issn = "0007-0963",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata.

AU - Betz, R C

AU - König, K

AU - Flaquer, A

AU - Redler, S

AU - Eigelshoven, S

AU - Kortüm, Anne-Katrin

AU - Hanneken, S

AU - Hillmer, A

AU - Tüting, T

AU - Lambert, J

AU - De Weert, J

AU - Kruse, R

AU - Lutz, G

AU - Blaumeiser, B

AU - Nöthen, M M

PY - 2008

Y1 - 2008

N2 - BACKGROUND: The functional R620W (c.1858C>T) variant of the protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) has been associated with a variety of autoimmune disorders. A recent study has suggested that R620W also contributes to the severe form of alopecia areata (AA). OBJECTIVES: We sought to replicate the finding of an association between PTPN22 and severe AA. In addition, we wanted to study the effect of PTPN22 on the general risk to develop AA and on other subtypes of AA (mild AA, early/late age at onset, positive/negative family history). METHODS: The R620W variant was genotyped in a large case-control sample of Belgian-German origin with 435 patients and 628 controls. RESULTS: Significant results were obtained for the overall collective of patients with AA (P=0.007). Subdividing the sample according to severity of AA, family history and age at onset, we detected lowest P-values for patients with the severe form of AA (Pcorr=0.036), with a positive family history (Pcorr=0.042) and with an age at onset

AB - BACKGROUND: The functional R620W (c.1858C>T) variant of the protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) has been associated with a variety of autoimmune disorders. A recent study has suggested that R620W also contributes to the severe form of alopecia areata (AA). OBJECTIVES: We sought to replicate the finding of an association between PTPN22 and severe AA. In addition, we wanted to study the effect of PTPN22 on the general risk to develop AA and on other subtypes of AA (mild AA, early/late age at onset, positive/negative family history). METHODS: The R620W variant was genotyped in a large case-control sample of Belgian-German origin with 435 patients and 628 controls. RESULTS: Significant results were obtained for the overall collective of patients with AA (P=0.007). Subdividing the sample according to severity of AA, family history and age at onset, we detected lowest P-values for patients with the severe form of AA (Pcorr=0.036), with a positive family history (Pcorr=0.042) and with an age at onset

M3 - SCORING: Zeitschriftenaufsatz

VL - 158

SP - 389

EP - 391

JO - BRIT J DERMATOL

JF - BRIT J DERMATOL

SN - 0007-0963

IS - 2

M1 - 2

ER -