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The Prevalence of Early‐ and Late‐Onset Bacterial, Viral and Fungal Respiratory Superinfections in Invasively Ventilated COVID‐19 Patients.

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The Prevalence of Early‐ and Late‐Onset Bacterial, Viral and Fungal Respiratory Superinfections in Invasively Ventilated COVID‐19 Patients. / Paparoupa, Maria; Aldemyati, Razaz; Roggenkamp, Hannes; Berinson, Benjamin; Nörz, Dominik; Olearo, Flaminia; Kluge, Stefan; Roedl, Kevin; Heer, Geraldine; Wichmann, Dominic.

In: J MED VIROL, Vol. 94, No. 5, 05.2022, p. 1920-1925.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Paparoupa, M, Aldemyati, R, Roggenkamp, H, Berinson, B, Nörz, D, Olearo, F, Kluge, S, Roedl, K, Heer, G & Wichmann, D 2022, 'The Prevalence of Early‐ and Late‐Onset Bacterial, Viral and Fungal Respiratory Superinfections in Invasively Ventilated COVID‐19 Patients.', J MED VIROL, vol. 94, no. 5, pp. 1920-1925. https://doi.org/10.1002/jmv.27548

APA

Paparoupa, M., Aldemyati, R., Roggenkamp, H., Berinson, B., Nörz, D., Olearo, F., Kluge, S., Roedl, K., Heer, G., & Wichmann, D. (2022). The Prevalence of Early‐ and Late‐Onset Bacterial, Viral and Fungal Respiratory Superinfections in Invasively Ventilated COVID‐19 Patients. J MED VIROL, 94(5), 1920-1925. https://doi.org/10.1002/jmv.27548

Vancouver

Paparoupa M, Aldemyati R, Roggenkamp H, Berinson B, Nörz D, Olearo F et al. The Prevalence of Early‐ and Late‐Onset Bacterial, Viral and Fungal Respiratory Superinfections in Invasively Ventilated COVID‐19 Patients. J MED VIROL. 2022 May;94(5):1920-1925. https://doi.org/10.1002/jmv.27548

Bibtex

@article{0820febcf9cd4a288c73e991e10841a7,
title = "The Prevalence of Early‐ and Late‐Onset Bacterial, Viral and Fungal Respiratory Superinfections in Invasively Ventilated COVID‐19 Patients.",
abstract = "The role of respiratory superinfections in patients with coronavirus disease 2019 (COVID-19) pneumonia remains unclear. We investigated the prevalence of early- and late-onset superinfections in invasively ventilated patients with COVID-19 pneumonia admitted to our department of intensive care medicine between March 2020 and November 2020. Of the 102 cases, 74 (72.5%) received invasive ventilation and were tested for viral, bacterial, and fungal pathogens on Days 0-7, 8-14, and 15-21 after the initiation of mechanical ventilation. Approximately 45% developed one or more respiratory superinfections. There was a clear correlation between the duration of invasive ventilation and the prevalence of coinfecting pathogens. Male patients with obesity and those suffering from chronic obstructive pulmonary disease and/or diabetes mellitus had a significantly higher probability to develop a respiratory superinfection. The prevalence of viral coinfections was high, with a predominance of the herpes simplex virus (HSV), followed by cytomegalovirus. No respiratory viruses or intracellular bacteria were detected in our cohort. We observed a high coincidence between Aspergillus fumigatus and HSV infection. Gram-negative bacteria were the most frequent pathogen group. Klebsiella aerogenes was detected early after intubation, while Klebsiella pneumoniae and Pseudomonas aeruginosa were related to a prolonged respiratory weaning.",
author = "Maria Paparoupa and Razaz Aldemyati and Hannes Roggenkamp and Benjamin Berinson and Dominik N{\"o}rz and Flaminia Olearo and Stefan Kluge and Kevin Roedl and Geraldine Heer and Dominic Wichmann",
year = "2022",
month = may,
doi = "10.1002/jmv.27548",
language = "English",
volume = "94",
pages = "1920--1925",
journal = "J MED VIROL",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - The Prevalence of Early‐ and Late‐Onset Bacterial, Viral and Fungal Respiratory Superinfections in Invasively Ventilated COVID‐19 Patients.

AU - Paparoupa, Maria

AU - Aldemyati, Razaz

AU - Roggenkamp, Hannes

AU - Berinson, Benjamin

AU - Nörz, Dominik

AU - Olearo, Flaminia

AU - Kluge, Stefan

AU - Roedl, Kevin

AU - Heer, Geraldine

AU - Wichmann, Dominic

PY - 2022/5

Y1 - 2022/5

N2 - The role of respiratory superinfections in patients with coronavirus disease 2019 (COVID-19) pneumonia remains unclear. We investigated the prevalence of early- and late-onset superinfections in invasively ventilated patients with COVID-19 pneumonia admitted to our department of intensive care medicine between March 2020 and November 2020. Of the 102 cases, 74 (72.5%) received invasive ventilation and were tested for viral, bacterial, and fungal pathogens on Days 0-7, 8-14, and 15-21 after the initiation of mechanical ventilation. Approximately 45% developed one or more respiratory superinfections. There was a clear correlation between the duration of invasive ventilation and the prevalence of coinfecting pathogens. Male patients with obesity and those suffering from chronic obstructive pulmonary disease and/or diabetes mellitus had a significantly higher probability to develop a respiratory superinfection. The prevalence of viral coinfections was high, with a predominance of the herpes simplex virus (HSV), followed by cytomegalovirus. No respiratory viruses or intracellular bacteria were detected in our cohort. We observed a high coincidence between Aspergillus fumigatus and HSV infection. Gram-negative bacteria were the most frequent pathogen group. Klebsiella aerogenes was detected early after intubation, while Klebsiella pneumoniae and Pseudomonas aeruginosa were related to a prolonged respiratory weaning.

AB - The role of respiratory superinfections in patients with coronavirus disease 2019 (COVID-19) pneumonia remains unclear. We investigated the prevalence of early- and late-onset superinfections in invasively ventilated patients with COVID-19 pneumonia admitted to our department of intensive care medicine between March 2020 and November 2020. Of the 102 cases, 74 (72.5%) received invasive ventilation and were tested for viral, bacterial, and fungal pathogens on Days 0-7, 8-14, and 15-21 after the initiation of mechanical ventilation. Approximately 45% developed one or more respiratory superinfections. There was a clear correlation between the duration of invasive ventilation and the prevalence of coinfecting pathogens. Male patients with obesity and those suffering from chronic obstructive pulmonary disease and/or diabetes mellitus had a significantly higher probability to develop a respiratory superinfection. The prevalence of viral coinfections was high, with a predominance of the herpes simplex virus (HSV), followed by cytomegalovirus. No respiratory viruses or intracellular bacteria were detected in our cohort. We observed a high coincidence between Aspergillus fumigatus and HSV infection. Gram-negative bacteria were the most frequent pathogen group. Klebsiella aerogenes was detected early after intubation, while Klebsiella pneumoniae and Pseudomonas aeruginosa were related to a prolonged respiratory weaning.

U2 - 10.1002/jmv.27548

DO - 10.1002/jmv.27548

M3 - SCORING: Journal article

VL - 94

SP - 1920

EP - 1925

JO - J MED VIROL

JF - J MED VIROL

SN - 0146-6615

IS - 5

ER -