Research ExplorerPublicationsThe Predictive Significance of Metastasis-Associated in Colo...

The Predictive Significance of Metastasis-Associated in Colon Cancer-1 (MACC1) in Primary Breast Cancer

Standard

The Predictive Significance of Metastasis-Associated in Colon Cancer-1 (MACC1) in Primary Breast Cancer. / Prguda-Mujic, J.; Milde-Langosch, K.; Mueller, V.; Suljagic, M.; Coric, J.; Ler, D.

In: ANN CLIN LAB SCI, Vol. 48, No. 2, 03.2018, p. 191-196.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Prguda-Mujic, J, Milde-Langosch, K, Mueller, V, Suljagic, M, Coric, J & Ler, D 2018, 'The Predictive Significance of Metastasis-Associated in Colon Cancer-1 (MACC1) in Primary Breast Cancer', ANN CLIN LAB SCI, vol. 48, no. 2, pp. 191-196. <https://www.ncbi.nlm.nih.gov/pubmed/29678846 http://www.annclinlabsci.org/content/48/2/191.long>

APA

Prguda-Mujic, J., Milde-Langosch, K., Mueller, V., Suljagic, M., Coric, J., & Ler, D. (2018). The Predictive Significance of Metastasis-Associated in Colon Cancer-1 (MACC1) in Primary Breast Cancer. ANN CLIN LAB SCI, 48(2), 191-196. https://www.ncbi.nlm.nih.gov/pubmed/29678846 http://www.annclinlabsci.org/content/48/2/191.long

Vancouver

Prguda-Mujic J, Milde-Langosch K, Mueller V, Suljagic M, Coric J, Ler D. The Predictive Significance of Metastasis-Associated in Colon Cancer-1 (MACC1) in Primary Breast Cancer. ANN CLIN LAB SCI. 2018 Mar;48(2):191-196.

Bibtex

@article{45b1578951514940accb7fbc0323842c,
title = "The Predictive Significance of Metastasis-Associated in Colon Cancer-1 (MACC1) in Primary Breast Cancer",
abstract = "BACKGROUND: Metastasis-Associated in Colon Cancer-1(MACC1) was first identified as a transcriptional activator of the HGF/MET pathway. Deregulation of HGF/MET signaling is reported as a prognostic marker for tumorigenesis, early stage invasion, and metastasis which is associated with poor clinical outcome in breast cancer patients. The aim of the present study was to further investigate the prognostic or predictive value of MACC1 expression in breast cancer. MATERIALS AND METHODS: We analyzed the MACC1 expression in 105 primary breast cancer samples by Western-Blot analysis and immunohistochemistry. RESULTS: A significant correlation of high MACC1 expression with shorter disease-free survival was found within the group of lymph-node-negative patients. Additionally, an association of high MACC1 expression and shorter disease-free survival was observed within estrogen receptor positive tumors and patients without adjuvant chemotherapy. CONCLUSION: Our results support a biologic role and potentially open the perspective for the use of MACC1 as a prognostic marker for treatment decision in breast cancer patients.",
keywords = "Adult Aged Breast Neoplasms/*metabolism/*pathology Female Follow-Up Studies Gene Expression Regulation, Neoplastic/*physiology HEK293 Cells Humans Kaplan-Meier Estimate Middle Aged Prognosis Retrospective Studies Statistics as Topic Transcription Factors/genetics/*metabolism Transfection Macc1 breast cancer c-MET lymph node status treatment",
author = "J. Prguda-Mujic and K. Milde-Langosch and V. Mueller and M. Suljagic and J. Coric and D. Ler",
note = "{\textcopyright} 2018 by the Association of Clinical Scientists, Inc.",
year = "2018",
month = mar,
language = "English",
volume = "48",
pages = "191--196",
journal = "ANN CLIN LAB SCI",
issn = "0091-7370",
publisher = "Association of Clinical Scientists",
number = "2",

}

RIS

TY - JOUR

T1 - The Predictive Significance of Metastasis-Associated in Colon Cancer-1 (MACC1) in Primary Breast Cancer

AU - Prguda-Mujic, J.

AU - Milde-Langosch, K.

AU - Mueller, V.

AU - Suljagic, M.

AU - Coric, J.

AU - Ler, D.

N1 - © 2018 by the Association of Clinical Scientists, Inc.

PY - 2018/3

Y1 - 2018/3

N2 - BACKGROUND: Metastasis-Associated in Colon Cancer-1(MACC1) was first identified as a transcriptional activator of the HGF/MET pathway. Deregulation of HGF/MET signaling is reported as a prognostic marker for tumorigenesis, early stage invasion, and metastasis which is associated with poor clinical outcome in breast cancer patients. The aim of the present study was to further investigate the prognostic or predictive value of MACC1 expression in breast cancer. MATERIALS AND METHODS: We analyzed the MACC1 expression in 105 primary breast cancer samples by Western-Blot analysis and immunohistochemistry. RESULTS: A significant correlation of high MACC1 expression with shorter disease-free survival was found within the group of lymph-node-negative patients. Additionally, an association of high MACC1 expression and shorter disease-free survival was observed within estrogen receptor positive tumors and patients without adjuvant chemotherapy. CONCLUSION: Our results support a biologic role and potentially open the perspective for the use of MACC1 as a prognostic marker for treatment decision in breast cancer patients.

AB - BACKGROUND: Metastasis-Associated in Colon Cancer-1(MACC1) was first identified as a transcriptional activator of the HGF/MET pathway. Deregulation of HGF/MET signaling is reported as a prognostic marker for tumorigenesis, early stage invasion, and metastasis which is associated with poor clinical outcome in breast cancer patients. The aim of the present study was to further investigate the prognostic or predictive value of MACC1 expression in breast cancer. MATERIALS AND METHODS: We analyzed the MACC1 expression in 105 primary breast cancer samples by Western-Blot analysis and immunohistochemistry. RESULTS: A significant correlation of high MACC1 expression with shorter disease-free survival was found within the group of lymph-node-negative patients. Additionally, an association of high MACC1 expression and shorter disease-free survival was observed within estrogen receptor positive tumors and patients without adjuvant chemotherapy. CONCLUSION: Our results support a biologic role and potentially open the perspective for the use of MACC1 as a prognostic marker for treatment decision in breast cancer patients.

KW - Adult Aged Breast Neoplasms/metabolism/pathology Female Follow-Up Studies Gene Expression Regulation, Neoplastic/physiology HEK293 Cells Humans Kaplan-Meier Estimate Middle Aged Prognosis Retrospective Studies Statistics as Topic Transcription Factors/gen

M3 - SCORING: Journal article

C2 - 29678846

VL - 48

SP - 191

EP - 196

JO - ANN CLIN LAB SCI

JF - ANN CLIN LAB SCI

SN - 0091-7370

IS - 2

ER -