The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is expressed in a subpopulation of mature cortical interneurons characterized by reduced structural features and connectivity.
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The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is expressed in a subpopulation of mature cortical interneurons characterized by reduced structural features and connectivity. / Gómez-Climent, María Ángeles; Guirado, Ramón; Castillo-Gómez, Esther; Varea, Emilio; Gutierrez-Mecinas, María; Gilabert-Juan, Javier; García-Mompó, Clara; Vidueira, Sandra; Sanchez-Mataredona, David; Hernández, Samuel; Blasco-Ibáñez, José Miguel; Crespo, Carlos; Rutishauser, Urs; Schachner, Melitta; Nacher, Juan.
In: CEREB CORTEX, Vol. 21, No. 5, 5, 2011, p. 1028-1041.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is expressed in a subpopulation of mature cortical interneurons characterized by reduced structural features and connectivity.
AU - Gómez-Climent, María Ángeles
AU - Guirado, Ramón
AU - Castillo-Gómez, Esther
AU - Varea, Emilio
AU - Gutierrez-Mecinas, María
AU - Gilabert-Juan, Javier
AU - García-Mompó, Clara
AU - Vidueira, Sandra
AU - Sanchez-Mataredona, David
AU - Hernández, Samuel
AU - Blasco-Ibáñez, José Miguel
AU - Crespo, Carlos
AU - Rutishauser, Urs
AU - Schachner, Melitta
AU - Nacher, Juan
PY - 2011
Y1 - 2011
N2 - Principal neurons in the adult cerebral cortex undergo synaptic, dendritic, and spine remodeling in response to different stimuli, and several reports have demonstrated that the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) participates in these plastic processes. However, there is only limited information on the expression of this molecule on interneurons and on its role in the structural plasticity of these cells. We have found that PSA-NCAM is expressed in mature interneurons widely distributed in all the extension of the cerebral cortex and have excluded the expression of this molecule in most principal cells. Although PSA-NCAM expression is generally considered a marker of immature neurons, birth-dating analyses reveal that these interneurons do not have an adult or perinatal origin and that they are generated during embryonic development. PSA-NCAM expressing interneurons show reduced density of perisomatic and peridendritic puncta expressing different synaptic markers and receive less perisomatic synapses, when compared with interneurons lacking this molecule. Moreover, they have reduced dendritic arborization and spine density. These data indicate that PSA-NCAM expression is important for the connectivity of interneurons in the adult cerebral cortex and that its regulation may play an important role in the structural plasticity of inhibitory networks.
AB - Principal neurons in the adult cerebral cortex undergo synaptic, dendritic, and spine remodeling in response to different stimuli, and several reports have demonstrated that the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) participates in these plastic processes. However, there is only limited information on the expression of this molecule on interneurons and on its role in the structural plasticity of these cells. We have found that PSA-NCAM is expressed in mature interneurons widely distributed in all the extension of the cerebral cortex and have excluded the expression of this molecule in most principal cells. Although PSA-NCAM expression is generally considered a marker of immature neurons, birth-dating analyses reveal that these interneurons do not have an adult or perinatal origin and that they are generated during embryonic development. PSA-NCAM expressing interneurons show reduced density of perisomatic and peridendritic puncta expressing different synaptic markers and receive less perisomatic synapses, when compared with interneurons lacking this molecule. Moreover, they have reduced dendritic arborization and spine density. These data indicate that PSA-NCAM expression is important for the connectivity of interneurons in the adult cerebral cortex and that its regulation may play an important role in the structural plasticity of inhibitory networks.
M3 - SCORING: Journal article
VL - 21
SP - 1028
EP - 1041
JO - CEREB CORTEX
JF - CEREB CORTEX
SN - 1047-3211
IS - 5
M1 - 5
ER -