Research ExplorerPublicationsThe plasma contact system 2.0.

The plasma contact system 2.0.

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The plasma contact system 2.0. / Maas, Coen; Oschatz, Chris; Renné, Thomas.

In: SEMIN THROMB HEMOST, Vol. 37, No. 4, 4, 2011, p. 375-381.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Maas, C, Oschatz, C & Renné, T 2011, 'The plasma contact system 2.0.', SEMIN THROMB HEMOST, vol. 37, no. 4, 4, pp. 375-381. <http://www.ncbi.nlm.nih.gov/pubmed/21805443?dopt=Citation>

APA

Maas, C., Oschatz, C., & Renné, T. (2011). The plasma contact system 2.0. SEMIN THROMB HEMOST, 37(4), 375-381. [4]. http://www.ncbi.nlm.nih.gov/pubmed/21805443?dopt=Citation

Vancouver

Maas C, Oschatz C, Renné T. The plasma contact system 2.0. SEMIN THROMB HEMOST. 2011;37(4):375-381. 4.

Bibtex

@article{823d1428cb454c6a874fd33e99e8d4fb,
title = "The plasma contact system 2.0.",
abstract = "The contact system is a protease cascade that is initiated by factor XII activation on cardiovascular cells. The system starts procoagulant and proinflammatory reactions, via the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively. The biochemistry of the contact system in vitro is well understood. However, activators of the system in vivo and their contributions to disease states have remained enigmatic. Recent experimental and clinical data have identified misfolded proteins, collagens, and polyphosphates as the long-sought activators of the contact system in vivo. Here we present an overview about contact system activators and their contributions to health and pathology.",
keywords = "Animals, Humans, Blood Coagulation/*physiology, Kallikrein-Kinin System/*physiology, Factor XII/*physiology, Animals, Humans, Blood Coagulation/*physiology, Kallikrein-Kinin System/*physiology, Factor XII/*physiology",
author = "Coen Maas and Chris Oschatz and Thomas Renn{\'e}",
year = "2011",
language = "English",
volume = "37",
pages = "375--381",
journal = "SEMIN THROMB HEMOST",
issn = "0094-6176",
publisher = "Thieme Medical Publishers",
number = "4",

}

RIS

TY - JOUR

T1 - The plasma contact system 2.0.

AU - Maas, Coen

AU - Oschatz, Chris

AU - Renné, Thomas

PY - 2011

Y1 - 2011

N2 - The contact system is a protease cascade that is initiated by factor XII activation on cardiovascular cells. The system starts procoagulant and proinflammatory reactions, via the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively. The biochemistry of the contact system in vitro is well understood. However, activators of the system in vivo and their contributions to disease states have remained enigmatic. Recent experimental and clinical data have identified misfolded proteins, collagens, and polyphosphates as the long-sought activators of the contact system in vivo. Here we present an overview about contact system activators and their contributions to health and pathology.

AB - The contact system is a protease cascade that is initiated by factor XII activation on cardiovascular cells. The system starts procoagulant and proinflammatory reactions, via the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively. The biochemistry of the contact system in vitro is well understood. However, activators of the system in vivo and their contributions to disease states have remained enigmatic. Recent experimental and clinical data have identified misfolded proteins, collagens, and polyphosphates as the long-sought activators of the contact system in vivo. Here we present an overview about contact system activators and their contributions to health and pathology.

KW - Animals

KW - Humans

KW - Blood Coagulation/physiology

KW - Kallikrein-Kinin System/physiology

KW - Factor XII/physiology

KW - Animals

KW - Humans

KW - Blood Coagulation/physiology

KW - Kallikrein-Kinin System/physiology

KW - Factor XII/physiology

M3 - SCORING: Journal article

VL - 37

SP - 375

EP - 381

JO - SEMIN THROMB HEMOST

JF - SEMIN THROMB HEMOST

SN - 0094-6176

IS - 4

M1 - 4

ER -