The periaqueductal gray and Bayesian integration in placebo analgesia
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The periaqueductal gray and Bayesian integration in placebo analgesia. / Grahl, Arvina; Onat, Selim; Büchel, Christian.
In: ELIFE, Vol. 7, 20.03.2018, p. e32930.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The periaqueductal gray and Bayesian integration in placebo analgesia
AU - Grahl, Arvina
AU - Onat, Selim
AU - Büchel, Christian
N1 - © 2018, Grahl et al.
PY - 2018/3/20
Y1 - 2018/3/20
N2 - In placebo hypoalgesia research, the strength of treatment expectations and experiences are key components. However, the reliability or precision of expectations had been mostly ignored although being a likely source for interindividual differences. In the present study, we adopted a Bayesian framework, naturally combining expectation magnitudes and precisions. This postulates that expectations (prior) are integrated with incoming nociceptive information (likelihood) and both are weighted by their relative precision to form the pain percept and placebo effect. Sixty-two healthy subjects received heat pain during fMRI. Placebo effects were more pronounced in subjects with more precise treatment expectations and correlated positively with the relative precision of the prior expectation. Neural correlates of this precision were observed in the periaqueductal gray and the rostral ventromedial medulla, indicating that already at the level of the brainstem the precision of an expectation can influence pain perception presenting strong evidence for Bayesian integration in placebo hypoalgesia.
AB - In placebo hypoalgesia research, the strength of treatment expectations and experiences are key components. However, the reliability or precision of expectations had been mostly ignored although being a likely source for interindividual differences. In the present study, we adopted a Bayesian framework, naturally combining expectation magnitudes and precisions. This postulates that expectations (prior) are integrated with incoming nociceptive information (likelihood) and both are weighted by their relative precision to form the pain percept and placebo effect. Sixty-two healthy subjects received heat pain during fMRI. Placebo effects were more pronounced in subjects with more precise treatment expectations and correlated positively with the relative precision of the prior expectation. Neural correlates of this precision were observed in the periaqueductal gray and the rostral ventromedial medulla, indicating that already at the level of the brainstem the precision of an expectation can influence pain perception presenting strong evidence for Bayesian integration in placebo hypoalgesia.
U2 - 10.7554/eLife.32930
DO - 10.7554/eLife.32930
M3 - SCORING: Journal article
VL - 7
SP - e32930
JO - ELIFE
JF - ELIFE
SN - 2050-084X
ER -