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The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues

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The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues. / Cortesi, Filippo; Delfanti, Gloria; Casorati, Giulia; Dellabona, Paolo.

In: FRONT IMMUNOL, Vol. 9, 2018, p. 2375.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Cortesi, F, Delfanti, G, Casorati, G & Dellabona, P 2018, 'The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues', FRONT IMMUNOL, vol. 9, pp. 2375. https://doi.org/10.3389/fimmu.2018.02375

APA

Cortesi, F., Delfanti, G., Casorati, G., & Dellabona, P. (2018). The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues. FRONT IMMUNOL, 9, 2375. https://doi.org/10.3389/fimmu.2018.02375

Vancouver

Cortesi F, Delfanti G, Casorati G, Dellabona P. The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues. FRONT IMMUNOL. 2018;9:2375. https://doi.org/10.3389/fimmu.2018.02375

Bibtex

@article{619b1bf602c04a3b9ec2323618f30ac6,
title = "The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues",
abstract = "CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and stimulation by inflammatory cytokines, such as IL-12 and IL-18. Increasing evidence suggest that this occurs mainly upon NKT cell interaction with CD1d-expressing cells of the Mononuclear Phagocytic System, i.e., monocytes, macrophages and DCs, which patrol parenchymatous organs and mucosae to maintain tissue homeostasis and immune surveillance. In this review, we discuss critical examples of this crosstalk, presenting the known underlying mechanisms and their effects on both cell types and the environment, and suggest that the interaction with CD1d-expressing mononuclear phagocytes in tissues is the fundamental job of NKT cells.",
keywords = "Cell Communication, Dendritic Cells/immunology, Disease Susceptibility, Humans, Lymphoid Tissue/cytology, Mononuclear Phagocyte System/immunology, Myeloid Cells/immunology, Natural Killer T-Cells/immunology, Neoplasms/etiology, Organ Specificity/immunology, Phagocytes/immunology, Tumor Microenvironment",
author = "Filippo Cortesi and Gloria Delfanti and Giulia Casorati and Paolo Dellabona",
year = "2018",
doi = "10.3389/fimmu.2018.02375",
language = "English",
volume = "9",
pages = "2375",
journal = "FRONT IMMUNOL",
issn = "1664-3224",
publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues

AU - Cortesi, Filippo

AU - Delfanti, Gloria

AU - Casorati, Giulia

AU - Dellabona, Paolo

PY - 2018

Y1 - 2018

N2 - CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and stimulation by inflammatory cytokines, such as IL-12 and IL-18. Increasing evidence suggest that this occurs mainly upon NKT cell interaction with CD1d-expressing cells of the Mononuclear Phagocytic System, i.e., monocytes, macrophages and DCs, which patrol parenchymatous organs and mucosae to maintain tissue homeostasis and immune surveillance. In this review, we discuss critical examples of this crosstalk, presenting the known underlying mechanisms and their effects on both cell types and the environment, and suggest that the interaction with CD1d-expressing mononuclear phagocytes in tissues is the fundamental job of NKT cells.

AB - CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and stimulation by inflammatory cytokines, such as IL-12 and IL-18. Increasing evidence suggest that this occurs mainly upon NKT cell interaction with CD1d-expressing cells of the Mononuclear Phagocytic System, i.e., monocytes, macrophages and DCs, which patrol parenchymatous organs and mucosae to maintain tissue homeostasis and immune surveillance. In this review, we discuss critical examples of this crosstalk, presenting the known underlying mechanisms and their effects on both cell types and the environment, and suggest that the interaction with CD1d-expressing mononuclear phagocytes in tissues is the fundamental job of NKT cells.

KW - Cell Communication

KW - Dendritic Cells/immunology

KW - Disease Susceptibility

KW - Humans

KW - Lymphoid Tissue/cytology

KW - Mononuclear Phagocyte System/immunology

KW - Myeloid Cells/immunology

KW - Natural Killer T-Cells/immunology

KW - Neoplasms/etiology

KW - Organ Specificity/immunology

KW - Phagocytes/immunology

KW - Tumor Microenvironment

U2 - 10.3389/fimmu.2018.02375

DO - 10.3389/fimmu.2018.02375

M3 - SCORING: Review article

C2 - 30369933

VL - 9

SP - 2375

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

ER -