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The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw--results of a clinical case series with an average follow-up of 20 months

Standard

The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw--results of a clinical case series with an average follow-up of 20 months. / Stockmann, Philipp; Burger, Moritz; von Wilmowsky, Cornelius; Ebker, Tobias; Lutz, Rainer; Bauersachs, Anne; Nkenke, Emeka; Neukam, Friedrich Wilhelm; Wehrhan, Falk.

In: CLIN ORAL INVEST, Vol. 18, No. 4, 01.05.2014, p. 1299-304.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stockmann, P, Burger, M, von Wilmowsky, C, Ebker, T, Lutz, R, Bauersachs, A, Nkenke, E, Neukam, FW & Wehrhan, F 2014, 'The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw--results of a clinical case series with an average follow-up of 20 months', CLIN ORAL INVEST, vol. 18, no. 4, pp. 1299-304. https://doi.org/10.1007/s00784-013-1092-2

APA

Stockmann, P., Burger, M., von Wilmowsky, C., Ebker, T., Lutz, R., Bauersachs, A., Nkenke, E., Neukam, F. W., & Wehrhan, F. (2014). The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw--results of a clinical case series with an average follow-up of 20 months. CLIN ORAL INVEST, 18(4), 1299-304. https://doi.org/10.1007/s00784-013-1092-2

Vancouver

Stockmann P, Burger M, von Wilmowsky C, Ebker T, Lutz R, Bauersachs A et al. The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw--results of a clinical case series with an average follow-up of 20 months. CLIN ORAL INVEST. 2014 May 1;18(4):1299-304. https://doi.org/10.1007/s00784-013-1092-2

Bibtex

@article{88e1691c70544f819eec46810af2c81b,
title = "The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw--results of a clinical case series with an average follow-up of 20 months",
abstract = "OBJECTIVES: The present case series evaluates the success rate of osteotomy and primary wound closure in patients with bisphosphonate-associated osteonecrosis of the jaw (BRONJ).MATERIALS AND METHODS: Eighty patients suffering from BRONJ were included in the study. All patients received intravenous bisphosphonate therapy and underwent osteotomy and primary wound closure according to a standardised protocol. After discharge, the patients were reviewed on a regular basis over an average time period of 20 months.RESULTS: During follow-up in 11 patients, a recurrence of BRONJ occurred in the former operation field. Seventeen patients died due to their underlying disease. The success rate of osteotomy and primary wound closure in the treatment of BRONJ was calculated at 84.2 % 20 months after surgery. The results showed non-significant difference concerning the outcome of surgery in the different clinical stages of BRONJ.CONCLUSIONS: In accordance with previous studies, stage-independent osteotomy and primary wound closure combined with antibiotics shall be deemed a viable treatment option in patients suffering from BRONJ.CLINICAL RELEVANCE: With a high success rate, osteotomy in combination with primary wound closure seems to be a viable alternative to more conservative protocols in the treatment of BRONJ.",
author = "Philipp Stockmann and Moritz Burger and {von Wilmowsky}, Cornelius and Tobias Ebker and Rainer Lutz and Anne Bauersachs and Emeka Nkenke and Neukam, {Friedrich Wilhelm} and Falk Wehrhan",
year = "2014",
month = may,
day = "1",
doi = "10.1007/s00784-013-1092-2",
language = "English",
volume = "18",
pages = "1299--304",
journal = "CLIN ORAL INVEST",
issn = "1432-6981",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw--results of a clinical case series with an average follow-up of 20 months

AU - Stockmann, Philipp

AU - Burger, Moritz

AU - von Wilmowsky, Cornelius

AU - Ebker, Tobias

AU - Lutz, Rainer

AU - Bauersachs, Anne

AU - Nkenke, Emeka

AU - Neukam, Friedrich Wilhelm

AU - Wehrhan, Falk

PY - 2014/5/1

Y1 - 2014/5/1

N2 - OBJECTIVES: The present case series evaluates the success rate of osteotomy and primary wound closure in patients with bisphosphonate-associated osteonecrosis of the jaw (BRONJ).MATERIALS AND METHODS: Eighty patients suffering from BRONJ were included in the study. All patients received intravenous bisphosphonate therapy and underwent osteotomy and primary wound closure according to a standardised protocol. After discharge, the patients were reviewed on a regular basis over an average time period of 20 months.RESULTS: During follow-up in 11 patients, a recurrence of BRONJ occurred in the former operation field. Seventeen patients died due to their underlying disease. The success rate of osteotomy and primary wound closure in the treatment of BRONJ was calculated at 84.2 % 20 months after surgery. The results showed non-significant difference concerning the outcome of surgery in the different clinical stages of BRONJ.CONCLUSIONS: In accordance with previous studies, stage-independent osteotomy and primary wound closure combined with antibiotics shall be deemed a viable treatment option in patients suffering from BRONJ.CLINICAL RELEVANCE: With a high success rate, osteotomy in combination with primary wound closure seems to be a viable alternative to more conservative protocols in the treatment of BRONJ.

AB - OBJECTIVES: The present case series evaluates the success rate of osteotomy and primary wound closure in patients with bisphosphonate-associated osteonecrosis of the jaw (BRONJ).MATERIALS AND METHODS: Eighty patients suffering from BRONJ were included in the study. All patients received intravenous bisphosphonate therapy and underwent osteotomy and primary wound closure according to a standardised protocol. After discharge, the patients were reviewed on a regular basis over an average time period of 20 months.RESULTS: During follow-up in 11 patients, a recurrence of BRONJ occurred in the former operation field. Seventeen patients died due to their underlying disease. The success rate of osteotomy and primary wound closure in the treatment of BRONJ was calculated at 84.2 % 20 months after surgery. The results showed non-significant difference concerning the outcome of surgery in the different clinical stages of BRONJ.CONCLUSIONS: In accordance with previous studies, stage-independent osteotomy and primary wound closure combined with antibiotics shall be deemed a viable treatment option in patients suffering from BRONJ.CLINICAL RELEVANCE: With a high success rate, osteotomy in combination with primary wound closure seems to be a viable alternative to more conservative protocols in the treatment of BRONJ.

U2 - 10.1007/s00784-013-1092-2

DO - 10.1007/s00784-013-1092-2

M3 - SCORING: Journal article

C2 - 23989467

VL - 18

SP - 1299

EP - 1304

JO - CLIN ORAL INVEST

JF - CLIN ORAL INVEST

SN - 1432-6981

IS - 4

ER -