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The Neutrophil-to-lymphocyte Ratio as a Prognostic Factor for Patients with Urothelial Carcinoma of the Bladder Following Radical Cystectomy

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The Neutrophil-to-lymphocyte Ratio as a Prognostic Factor for Patients with Urothelial Carcinoma of the Bladder Following Radical Cystectomy : Validation and Meta-analysis. / Lucca, Ilaria; Jichlinski, Patrice; Shariat, Shahrokh F; Rouprêt, Morgan; Rieken, Malte; Kluth, Luis A; Rink, Michael; Mathieu, Romain; Mbeutcha, Aurelie; Maj-Hes, Agnes; Fajkovic, Harun; Briganti, Alberto; Seitz, Christian; Karakiewicz, Pierre I; de Martino, Michela; Lotan, Yair; Babjuk, Marko; Klatte, Tobias.

In: EUR UROL FOCUS, Vol. 2, No. 1, 04.2016, p. 79-85.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lucca, I, Jichlinski, P, Shariat, SF, Rouprêt, M, Rieken, M, Kluth, LA, Rink, M, Mathieu, R, Mbeutcha, A, Maj-Hes, A, Fajkovic, H, Briganti, A, Seitz, C, Karakiewicz, PI, de Martino, M, Lotan, Y, Babjuk, M & Klatte, T 2016, 'The Neutrophil-to-lymphocyte Ratio as a Prognostic Factor for Patients with Urothelial Carcinoma of the Bladder Following Radical Cystectomy: Validation and Meta-analysis', EUR UROL FOCUS, vol. 2, no. 1, pp. 79-85. https://doi.org/10.1016/j.euf.2015.03.001

APA

Lucca, I., Jichlinski, P., Shariat, S. F., Rouprêt, M., Rieken, M., Kluth, L. A., Rink, M., Mathieu, R., Mbeutcha, A., Maj-Hes, A., Fajkovic, H., Briganti, A., Seitz, C., Karakiewicz, P. I., de Martino, M., Lotan, Y., Babjuk, M., & Klatte, T. (2016). The Neutrophil-to-lymphocyte Ratio as a Prognostic Factor for Patients with Urothelial Carcinoma of the Bladder Following Radical Cystectomy: Validation and Meta-analysis. EUR UROL FOCUS, 2(1), 79-85. https://doi.org/10.1016/j.euf.2015.03.001

Vancouver

Lucca I, Jichlinski P, Shariat SF, Rouprêt M, Rieken M, Kluth LA et al. The Neutrophil-to-lymphocyte Ratio as a Prognostic Factor for Patients with Urothelial Carcinoma of the Bladder Following Radical Cystectomy: Validation and Meta-analysis. EUR UROL FOCUS. 2016 Apr;2(1):79-85. https://doi.org/10.1016/j.euf.2015.03.001

Bibtex

@article{a10cb797ef7148f69b1b0855053cb8b6,
title = "The Neutrophil-to-lymphocyte Ratio as a Prognostic Factor for Patients with Urothelial Carcinoma of the Bladder Following Radical Cystectomy: Validation and Meta-analysis",
abstract = "BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic inflammatory response has been proposed as a prognostic factor for patients with urothelial carcinoma of the bladder (UCB) following radical cystectomy (RC).OBJECTIVE: To validate NLR as a prognostic biomarker and to perform a pooled meta-analysis.DESIGN, SETTING, AND PARTICIPANTS: The NLR was assessed in 4061 patients within 30 days before RC. A systematic review of the literature was undertaken using electronic databases.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Associations with overall survival (OS) and cancer-specific survival (CSS) were evaluated using Cox models. Hazard ratios (HRs) were pooled in a meta-analysis using random-effects modeling.RESULTS AND LIMITATIONS: A high NLR (≥2.7) was associated with advanced pathological tumor stages (p<0.001), lymph node involvement (p<0.001), lymphovascular invasion (p=0.008), and positive soft0tissue surgical margins (p=0.001). In multivariate analyses, a high NLR was independently associated with both OS (HR 1.11, 95% confidence interval [CI] 1.01-1.22; p=0.029) and cancer-specific survival (CSS) (HR 1.21, 95% CI 1.07-1.37, p=0.003). The discrimination of the multivariate models increased by 0.2% on inclusion of NLR. Five studies were included in the meta-analysis. The HR for NLR greater than the cutoff was 1.46 (95% CI 1.01-1.92) for OS and 1.51 (95% CI 1.17-1.85) for CSS. Limitations include the retrospective study design and the lack of standardized follow-up.CONCLUSION: In patients with UCB treated with RC, a high preoperative NLR is associated with more advanced tumor stage, lymph node metastasis, and worse prognosis. The NLR may be a readily available and useful biomarker for preoperative prognostic stratification.PATIENT SUMMARY: We investigated the neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker in patients with bladder cancer treated with radical cystectomy. We found that a high NLR is associated with worse oncologic outcomes, suggesting it could play a role in risk stratification.",
keywords = "Journal Article",
author = "Ilaria Lucca and Patrice Jichlinski and Shariat, {Shahrokh F} and Morgan Roupr{\^e}t and Malte Rieken and Kluth, {Luis A} and Michael Rink and Romain Mathieu and Aurelie Mbeutcha and Agnes Maj-Hes and Harun Fajkovic and Alberto Briganti and Christian Seitz and Karakiewicz, {Pierre I} and {de Martino}, Michela and Yair Lotan and Marko Babjuk and Tobias Klatte",
note = "Copyright {\textcopyright} 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.",
year = "2016",
month = apr,
doi = "10.1016/j.euf.2015.03.001",
language = "English",
volume = "2",
pages = "79--85",
journal = "EUR UROL FOCUS",
issn = "2405-4569",
publisher = "Elsevier BV",
number = "1",

}

RIS

TY - JOUR

T1 - The Neutrophil-to-lymphocyte Ratio as a Prognostic Factor for Patients with Urothelial Carcinoma of the Bladder Following Radical Cystectomy

T2 - Validation and Meta-analysis

AU - Lucca, Ilaria

AU - Jichlinski, Patrice

AU - Shariat, Shahrokh F

AU - Rouprêt, Morgan

AU - Rieken, Malte

AU - Kluth, Luis A

AU - Rink, Michael

AU - Mathieu, Romain

AU - Mbeutcha, Aurelie

AU - Maj-Hes, Agnes

AU - Fajkovic, Harun

AU - Briganti, Alberto

AU - Seitz, Christian

AU - Karakiewicz, Pierre I

AU - de Martino, Michela

AU - Lotan, Yair

AU - Babjuk, Marko

AU - Klatte, Tobias

N1 - Copyright © 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.

PY - 2016/4

Y1 - 2016/4

N2 - BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic inflammatory response has been proposed as a prognostic factor for patients with urothelial carcinoma of the bladder (UCB) following radical cystectomy (RC).OBJECTIVE: To validate NLR as a prognostic biomarker and to perform a pooled meta-analysis.DESIGN, SETTING, AND PARTICIPANTS: The NLR was assessed in 4061 patients within 30 days before RC. A systematic review of the literature was undertaken using electronic databases.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Associations with overall survival (OS) and cancer-specific survival (CSS) were evaluated using Cox models. Hazard ratios (HRs) were pooled in a meta-analysis using random-effects modeling.RESULTS AND LIMITATIONS: A high NLR (≥2.7) was associated with advanced pathological tumor stages (p<0.001), lymph node involvement (p<0.001), lymphovascular invasion (p=0.008), and positive soft0tissue surgical margins (p=0.001). In multivariate analyses, a high NLR was independently associated with both OS (HR 1.11, 95% confidence interval [CI] 1.01-1.22; p=0.029) and cancer-specific survival (CSS) (HR 1.21, 95% CI 1.07-1.37, p=0.003). The discrimination of the multivariate models increased by 0.2% on inclusion of NLR. Five studies were included in the meta-analysis. The HR for NLR greater than the cutoff was 1.46 (95% CI 1.01-1.92) for OS and 1.51 (95% CI 1.17-1.85) for CSS. Limitations include the retrospective study design and the lack of standardized follow-up.CONCLUSION: In patients with UCB treated with RC, a high preoperative NLR is associated with more advanced tumor stage, lymph node metastasis, and worse prognosis. The NLR may be a readily available and useful biomarker for preoperative prognostic stratification.PATIENT SUMMARY: We investigated the neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker in patients with bladder cancer treated with radical cystectomy. We found that a high NLR is associated with worse oncologic outcomes, suggesting it could play a role in risk stratification.

AB - BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic inflammatory response has been proposed as a prognostic factor for patients with urothelial carcinoma of the bladder (UCB) following radical cystectomy (RC).OBJECTIVE: To validate NLR as a prognostic biomarker and to perform a pooled meta-analysis.DESIGN, SETTING, AND PARTICIPANTS: The NLR was assessed in 4061 patients within 30 days before RC. A systematic review of the literature was undertaken using electronic databases.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Associations with overall survival (OS) and cancer-specific survival (CSS) were evaluated using Cox models. Hazard ratios (HRs) were pooled in a meta-analysis using random-effects modeling.RESULTS AND LIMITATIONS: A high NLR (≥2.7) was associated with advanced pathological tumor stages (p<0.001), lymph node involvement (p<0.001), lymphovascular invasion (p=0.008), and positive soft0tissue surgical margins (p=0.001). In multivariate analyses, a high NLR was independently associated with both OS (HR 1.11, 95% confidence interval [CI] 1.01-1.22; p=0.029) and cancer-specific survival (CSS) (HR 1.21, 95% CI 1.07-1.37, p=0.003). The discrimination of the multivariate models increased by 0.2% on inclusion of NLR. Five studies were included in the meta-analysis. The HR for NLR greater than the cutoff was 1.46 (95% CI 1.01-1.92) for OS and 1.51 (95% CI 1.17-1.85) for CSS. Limitations include the retrospective study design and the lack of standardized follow-up.CONCLUSION: In patients with UCB treated with RC, a high preoperative NLR is associated with more advanced tumor stage, lymph node metastasis, and worse prognosis. The NLR may be a readily available and useful biomarker for preoperative prognostic stratification.PATIENT SUMMARY: We investigated the neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker in patients with bladder cancer treated with radical cystectomy. We found that a high NLR is associated with worse oncologic outcomes, suggesting it could play a role in risk stratification.

KW - Journal Article

U2 - 10.1016/j.euf.2015.03.001

DO - 10.1016/j.euf.2015.03.001

M3 - SCORING: Journal article

C2 - 28723455

VL - 2

SP - 79

EP - 85

JO - EUR UROL FOCUS

JF - EUR UROL FOCUS

SN - 2405-4569

IS - 1

ER -