The neonatal window of opportunity-early priming for life
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The neonatal window of opportunity-early priming for life. / Renz, Harald; Adkins, Becky D; Bartfeld, Sina; Blumberg, Richard S; Farber, Donna L; Garssen, Johan; Ghazal, Peter; Hackam, David J; Marsland, Benjamin J; McCoy, Kathy D; Penders, John; Prinz, Immo; Verhasselt, Valerie; von Mutius, Erika; Weiser, Jeffrey N; Wesemann, Duane R; Hornef, Mathias W.
In: J ALLERGY CLIN IMMUN, Vol. 141, No. 4, 04.2018, p. 1212-1214.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The neonatal window of opportunity-early priming for life
AU - Renz, Harald
AU - Adkins, Becky D
AU - Bartfeld, Sina
AU - Blumberg, Richard S
AU - Farber, Donna L
AU - Garssen, Johan
AU - Ghazal, Peter
AU - Hackam, David J
AU - Marsland, Benjamin J
AU - McCoy, Kathy D
AU - Penders, John
AU - Prinz, Immo
AU - Verhasselt, Valerie
AU - von Mutius, Erika
AU - Weiser, Jeffrey N
AU - Wesemann, Duane R
AU - Hornef, Mathias W
PY - 2018/4
Y1 - 2018/4
N2 - The concept of the neonatal window of opportunity assigns the early postnatal period a critical role for lifelong host-microbial and immune homeostasis. It is supported by epidemiological evidence that links postnatal environmental exposure with disease susceptibility and mechanisms in the neonate host that facilitate the postnatal transposition, establish a stable microbiome, and promote immune maturation. During the conference on “The neonatal window of opportunity – early priming for life,” postnatal micro-biome and immune maturation, epidemiological evidence, and fundamental mechanisms were discussed to identify new targets for future preventive and interventional measures.From December 5 to 7, 2016, the Herrenhausen Conference “The neonatal window of opportunity – early priming for life” took place at Hannover, Germany, sponsored by the Volkswagen Foundation. The concept of the “neonatal window of opportunity,” that is, a critical nonredundant time frame in a newborn’s life during which environmental factors drive immune and tissue maturation and influence the susceptibility to immune-mediated and other diseases in adult life, was discussed.
AB - The concept of the neonatal window of opportunity assigns the early postnatal period a critical role for lifelong host-microbial and immune homeostasis. It is supported by epidemiological evidence that links postnatal environmental exposure with disease susceptibility and mechanisms in the neonate host that facilitate the postnatal transposition, establish a stable microbiome, and promote immune maturation. During the conference on “The neonatal window of opportunity – early priming for life,” postnatal micro-biome and immune maturation, epidemiological evidence, and fundamental mechanisms were discussed to identify new targets for future preventive and interventional measures.From December 5 to 7, 2016, the Herrenhausen Conference “The neonatal window of opportunity – early priming for life” took place at Hannover, Germany, sponsored by the Volkswagen Foundation. The concept of the “neonatal window of opportunity,” that is, a critical nonredundant time frame in a newborn’s life during which environmental factors drive immune and tissue maturation and influence the susceptibility to immune-mediated and other diseases in adult life, was discussed.
KW - Child Development/physiology
KW - Environmental Exposure
KW - Homeostasis
KW - Host Microbial Interactions/immunology
KW - Humans
KW - Hypersensitivity/immunology
KW - Immune System/growth & development
KW - Immune Tolerance
KW - Infant, Newborn
KW - Microbiota
KW - Risk Factors
U2 - 10.1016/j.jaci.2017.11.019
DO - 10.1016/j.jaci.2017.11.019
M3 - SCORING: Journal article
C2 - 29247715
VL - 141
SP - 1212
EP - 1214
JO - J ALLERGY CLIN IMMUN
JF - J ALLERGY CLIN IMMUN
SN - 0091-6749
IS - 4
ER -