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The multiple faces of autoimmune-mediated bone loss

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The multiple faces of autoimmune-mediated bone loss. / Schett, Georg; David, Jean-Pierre.

In: NAT REV ENDOCRINOL, Vol. 6, No. 12, 01.12.2010, p. 698-706.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schett, G & David, J-P 2010, 'The multiple faces of autoimmune-mediated bone loss', NAT REV ENDOCRINOL, vol. 6, no. 12, pp. 698-706. https://doi.org/10.1038/nrendo.2010.190

APA

Schett, G., & David, J-P. (2010). The multiple faces of autoimmune-mediated bone loss. NAT REV ENDOCRINOL, 6(12), 698-706. https://doi.org/10.1038/nrendo.2010.190

Vancouver

Schett G, David J-P. The multiple faces of autoimmune-mediated bone loss. NAT REV ENDOCRINOL. 2010 Dec 1;6(12):698-706. https://doi.org/10.1038/nrendo.2010.190

Bibtex

@article{15e2c232659f40c098857b5888dd44fa,
title = "The multiple faces of autoimmune-mediated bone loss",
abstract = "Inflammation perturbs normal bone homeostasis and is known to induce bone loss, as it promotes both local cartilage degradation and local and systemic bone destruction by osteoclasts, as well as inhibits bone formation by osteoblasts. Thus, not surprisingly, inflammatory autoimmune diseases often lead to local and/or general bone loss. However, the mechanisms that target the bone in autoimmune disease are complex and diverse, as they range from a direct attack on the bone and cartilage by the immune cells to indirect consequences of disturbances of the systemic control of bone remodeling. This Review discusses current understanding of the mechanisms of autoimmune-mediated bone loss in view of new insight from two new fields of research: osteoimmunology, which analyzes the direct effect of immune cells on bone, and the integrative metabolism approach, which established the existence of neuroendocrine loops that regulate bone remodeling.",
keywords = "Animals, Autoimmune Diseases, Bone Remodeling, Bone Resorption, Diabetes Mellitus, Type 1, Humans, Lupus Erythematosus, Systemic, Models, Biological, Thyroid Diseases",
author = "Georg Schett and Jean-Pierre David",
year = "2010",
month = dec,
day = "1",
doi = "10.1038/nrendo.2010.190",
language = "English",
volume = "6",
pages = "698--706",
journal = "NAT REV ENDOCRINOL",
issn = "1759-5029",
publisher = "NATURE PUBLISHING GROUP",
number = "12",

}

RIS

TY - JOUR

T1 - The multiple faces of autoimmune-mediated bone loss

AU - Schett, Georg

AU - David, Jean-Pierre

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Inflammation perturbs normal bone homeostasis and is known to induce bone loss, as it promotes both local cartilage degradation and local and systemic bone destruction by osteoclasts, as well as inhibits bone formation by osteoblasts. Thus, not surprisingly, inflammatory autoimmune diseases often lead to local and/or general bone loss. However, the mechanisms that target the bone in autoimmune disease are complex and diverse, as they range from a direct attack on the bone and cartilage by the immune cells to indirect consequences of disturbances of the systemic control of bone remodeling. This Review discusses current understanding of the mechanisms of autoimmune-mediated bone loss in view of new insight from two new fields of research: osteoimmunology, which analyzes the direct effect of immune cells on bone, and the integrative metabolism approach, which established the existence of neuroendocrine loops that regulate bone remodeling.

AB - Inflammation perturbs normal bone homeostasis and is known to induce bone loss, as it promotes both local cartilage degradation and local and systemic bone destruction by osteoclasts, as well as inhibits bone formation by osteoblasts. Thus, not surprisingly, inflammatory autoimmune diseases often lead to local and/or general bone loss. However, the mechanisms that target the bone in autoimmune disease are complex and diverse, as they range from a direct attack on the bone and cartilage by the immune cells to indirect consequences of disturbances of the systemic control of bone remodeling. This Review discusses current understanding of the mechanisms of autoimmune-mediated bone loss in view of new insight from two new fields of research: osteoimmunology, which analyzes the direct effect of immune cells on bone, and the integrative metabolism approach, which established the existence of neuroendocrine loops that regulate bone remodeling.

KW - Animals

KW - Autoimmune Diseases

KW - Bone Remodeling

KW - Bone Resorption

KW - Diabetes Mellitus, Type 1

KW - Humans

KW - Lupus Erythematosus, Systemic

KW - Models, Biological

KW - Thyroid Diseases

U2 - 10.1038/nrendo.2010.190

DO - 10.1038/nrendo.2010.190

M3 - SCORING: Journal article

C2 - 21045788

VL - 6

SP - 698

EP - 706

JO - NAT REV ENDOCRINOL

JF - NAT REV ENDOCRINOL

SN - 1759-5029

IS - 12

ER -