The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination
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The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination. / Taesler, Philipp; Rose, Michael.
In: SCI REP-UK, Vol. 11, No. 1, 07.05.2021, p. 9795.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination
AU - Taesler, Philipp
AU - Rose, Michael
PY - 2021/5/7
Y1 - 2021/5/7
N2 - The experience of pain is generated by activations throughout a complex pain network with the insular cortex as a central processing area. The state of ongoing oscillatory activity can influence subsequent processing throughout this network. In particular the ongoing theta-band power can be relevant for later pain processing, however a direct functional relation to post-stimulus processing or behaviour is missing. Here, we used a non-invasive brain-computer interface to either increase or decrease ongoing theta-band power originating in the insular cortex. Our results show a differential modulation of oscillatory power and even more important a transfer to independently measured pain processing and sensation. Pain evoked neural power and subjective pain discrimination were differentially affected by the induced modulations of the oscillatory state. The results demonstrate a functional relevance of insular based theta-band oscillatory states for the processing and subjective discrimination of nociceptive stimuli and offer the perspective for clinical applications.
AB - The experience of pain is generated by activations throughout a complex pain network with the insular cortex as a central processing area. The state of ongoing oscillatory activity can influence subsequent processing throughout this network. In particular the ongoing theta-band power can be relevant for later pain processing, however a direct functional relation to post-stimulus processing or behaviour is missing. Here, we used a non-invasive brain-computer interface to either increase or decrease ongoing theta-band power originating in the insular cortex. Our results show a differential modulation of oscillatory power and even more important a transfer to independently measured pain processing and sensation. Pain evoked neural power and subjective pain discrimination were differentially affected by the induced modulations of the oscillatory state. The results demonstrate a functional relevance of insular based theta-band oscillatory states for the processing and subjective discrimination of nociceptive stimuli and offer the perspective for clinical applications.
U2 - 10.1038/s41598-021-89206-3
DO - 10.1038/s41598-021-89206-3
M3 - SCORING: Journal article
C2 - 33963226
VL - 11
SP - 9795
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
ER -