The MLL recombinome of acute leukemias in 2013

C Meyer; J Hofmann; T Burmeister; D Gröger; T S Park; M Emerenciano; M Pombo de Oliveira; A Renneville; P Villarese; E Macintyre; H Cavé; E Clappier; K Mass-Malo; J Zuna; J Trka; E De Braekeleer; M De Braekeleer; S H Oh; G Tsaur; L Fechina; V H J van der Velden; J J M van Dongen; E Delabesse; R Binato; M L M Silva; A Kustanovich; O Aleinikova; M H Harris; T Lund-Aho; V Juvonen; O Heidenreich; J Vormoor; W W L Choi; M Jarosova; A Kolenova; C Bueno; P Menendez; S Wehner; C Eckert; P Talmant; S Tondeur; E Lippert; E Launay; C Henry; P Ballerini; H Lapillone; M B Callanan; J M Cayuela; C Herbaux; G Cazzaniga; P M Kakadiya; S Bohlander; M Ahlmann; J R Choi; P Gameiro; D S Lee; J Krauter; P Cornillet-Lefebvre; G Te Kronnie; B W Schäfer; S Kubetzko; C N Alonso; U zur Stadt; R Sutton; N C Venn; S Izraeli; L Trakhtenbrot; H O Madsen; P Archer; J Hancock; N Cerveira; M R Teixeira; L Lo Nigro; A Möricke; M Stanulla; M Schrappe; L Sedék; T Szczepański; C M Zwaan; E A Coenen; M M van den Heuvel-Eibrink; S Strehl; M Dworzak; R Panzer-Grümayer; T Dingermann; T Klingebiel; R Marschalek

doi:10.1038/leu.2013.135

The MLL recombinome of acute leukemias in 2013

Standard

The MLL recombinome of acute leukemias in 2013. / Meyer, C; Hofmann, J; Burmeister, T; Gröger, D; Park, T S; Emerenciano, M; Pombo de Oliveira, M; Renneville, A; Villarese, P; Macintyre, E; Cavé, H; Clappier, E; Mass-Malo, K; Zuna, J; Trka, J; De Braekeleer, E; De Braekeleer, M; Oh, S H; Tsaur, G; Fechina, L; van der Velden, V H J; van Dongen, J J M; Delabesse, E; Binato, R; Silva, M L M; Kustanovich, A; Aleinikova, O; Harris, M H; Lund-Aho, T; Juvonen, V; Heidenreich, O; Vormoor, J; Choi, W W L; Jarosova, M; Kolenova, A; Bueno, C; Menendez, P; Wehner, S; Eckert, C; Talmant, P; Tondeur, S; Lippert, E; Launay, E; Henry, C; Ballerini, P; Lapillone, H; Callanan, M B; Cayuela, J M; Herbaux, C; Cazzaniga, G; Kakadiya, P M; Bohlander, S; Ahlmann, M; Choi, J R; Gameiro, P; Lee, D S; Krauter, J; Cornillet-Lefebvre, P; Te Kronnie, G; Schäfer, B W; Kubetzko, S; Alonso, C N; zur Stadt, U; Sutton, R; Venn, N C; Izraeli, S; Trakhtenbrot, L; Madsen, H O; Archer, P; Hancock, J; Cerveira, N; Teixeira, M R; Lo Nigro, L; Möricke, A; Stanulla, M; Schrappe, M; Sedék, L; Szczepański, T; Zwaan, C M; Coenen, E A; van den Heuvel-Eibrink, M M; Strehl, S; Dworzak, M; Panzer-Grümayer, R; Dingermann, T; Klingebiel, T; Marschalek, R.

In: LEUKEMIA, Vol. 27, No. 11, 01.11.2013, p. 2165-76.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Meyer, C, Hofmann, J, Burmeister, T, Gröger, D, Park, TS, Emerenciano, M, Pombo de Oliveira, M, Renneville, A, Villarese, P, Macintyre, E, Cavé, H, Clappier, E, Mass-Malo, K, Zuna, J, Trka, J, De Braekeleer, E, De Braekeleer, M, Oh, SH, Tsaur, G, Fechina, L, van der Velden, VHJ, van Dongen, JJM, Delabesse, E, Binato, R, Silva, MLM, Kustanovich, A, Aleinikova, O, Harris, MH, Lund-Aho, T, Juvonen, V, Heidenreich, O, Vormoor, J, Choi, WWL, Jarosova, M, Kolenova, A, Bueno, C, Menendez, P, Wehner, S, Eckert, C, Talmant, P, Tondeur, S, Lippert, E, Launay, E, Henry, C, Ballerini, P, Lapillone, H, Callanan, MB, Cayuela, JM, Herbaux, C, Cazzaniga, G, Kakadiya, PM, Bohlander, S, Ahlmann, M, Choi, JR, Gameiro, P, Lee, DS, Krauter, J, Cornillet-Lefebvre, P, Te Kronnie, G, Schäfer, BW, Kubetzko, S, Alonso, CN, zur Stadt, U, Sutton, R, Venn, NC, Izraeli, S, Trakhtenbrot, L, Madsen, HO, Archer, P, Hancock, J, Cerveira, N, Teixeira, MR, Lo Nigro, L, Möricke, A, Stanulla, M, Schrappe, M, Sedék, L, Szczepański, T, Zwaan, CM, Coenen, EA, van den Heuvel-Eibrink, MM, Strehl, S, Dworzak, M, Panzer-Grümayer, R, Dingermann, T, Klingebiel, T & Marschalek, R 2013, 'The MLL recombinome of acute leukemias in 2013', LEUKEMIA, vol. 27, no. 11, pp. 2165-76. https://doi.org/10.1038/leu.2013.135

APA

Meyer, C., Hofmann, J., Burmeister, T., Gröger, D., Park, T. S., Emerenciano, M., Pombo de Oliveira, M., Renneville, A., Villarese, P., Macintyre, E., Cavé, H., Clappier, E., Mass-Malo, K., Zuna, J., Trka, J., De Braekeleer, E., De Braekeleer, M., Oh, S. H., Tsaur, G., ... Marschalek, R. (2013). The MLL recombinome of acute leukemias in 2013. LEUKEMIA, 27(11), 2165-76. https://doi.org/10.1038/leu.2013.135

Vancouver

Meyer C, Hofmann J, Burmeister T, Gröger D, Park TS, Emerenciano M et al. The MLL recombinome of acute leukemias in 2013. LEUKEMIA. 2013 Nov 1;27(11):2165-76. https://doi.org/10.1038/leu.2013.135

Bibtex

@article{4ac6ec092ce74dedac7000385bccc4ec,

title = "The MLL recombinome of acute leukemias in 2013",

abstract = "Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the MLL gene (≈ 90%): AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, ELL, partial tandem duplications (MLL PTDs) and MLLT4/AF6, respectively. The MLL breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal MLL fusions deriving from complex rearrangements.",

keywords = "Acute Disease, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Chromosome Breakage, Female, Gene Rearrangement, Humans, Infant, Infant, Newborn, Leukemia, Male, Mice, Middle Aged, Myeloid-Lymphoid Leukemia Protein, Oncogene Proteins, Fusion, Polymerase Chain Reaction, Prognosis, Translocation, Genetic, Young Adult",

author = "C Meyer and J Hofmann and T Burmeister and D Gr{\"o}ger and Park, {T S} and M Emerenciano and {Pombo de Oliveira}, M and A Renneville and P Villarese and E Macintyre and H Cav{\'e} and E Clappier and K Mass-Malo and J Zuna and J Trka and {De Braekeleer}, E and {De Braekeleer}, M and Oh, {S H} and G Tsaur and L Fechina and {van der Velden}, {V H J} and {van Dongen}, {J J M} and E Delabesse and R Binato and Silva, {M L M} and A Kustanovich and O Aleinikova and Harris, {M H} and T Lund-Aho and V Juvonen and O Heidenreich and J Vormoor and Choi, {W W L} and M Jarosova and A Kolenova and C Bueno and P Menendez and S Wehner and C Eckert and P Talmant and S Tondeur and E Lippert and E Launay and C Henry and P Ballerini and H Lapillone and Callanan, {M B} and Cayuela, {J M} and C Herbaux and G Cazzaniga and Kakadiya, {P M} and S Bohlander and M Ahlmann and Choi, {J R} and P Gameiro and Lee, {D S} and J Krauter and P Cornillet-Lefebvre and {Te Kronnie}, G and Sch{\"a}fer, {B W} and S Kubetzko and Alonso, {C N} and {zur Stadt}, U and R Sutton and Venn, {N C} and S Izraeli and L Trakhtenbrot and Madsen, {H O} and P Archer and J Hancock and N Cerveira and Teixeira, {M R} and {Lo Nigro}, L and A M{\"o}ricke and M Stanulla and M Schrappe and L Sed{\'e}k and T Szczepa{\'n}ski and Zwaan, {C M} and Coenen, {E A} and {van den Heuvel-Eibrink}, {M M} and S Strehl and M Dworzak and R Panzer-Gr{\"u}mayer and T Dingermann and T Klingebiel and R Marschalek",

year = "2013",

month = nov,

day = "1",

doi = "10.1038/leu.2013.135",

language = "English",

volume = "27",

pages = "2165--76",

journal = "LEUKEMIA",

issn = "0887-6924",

publisher = "NATURE PUBLISHING GROUP",

number = "11",

}

RIS

TY - JOUR

T1 - The MLL recombinome of acute leukemias in 2013

AU - Meyer, C

AU - Hofmann, J

AU - Burmeister, T

AU - Gröger, D

AU - Park, T S

AU - Emerenciano, M

AU - Pombo de Oliveira, M

AU - Renneville, A

AU - Villarese, P

AU - Macintyre, E

AU - Cavé, H

AU - Clappier, E

AU - Mass-Malo, K

AU - Zuna, J

AU - Trka, J

AU - De Braekeleer, E

AU - De Braekeleer, M

AU - Oh, S H

AU - Tsaur, G

AU - Fechina, L

AU - van der Velden, V H J

AU - van Dongen, J J M

AU - Delabesse, E

AU - Binato, R

AU - Silva, M L M

AU - Kustanovich, A

AU - Aleinikova, O

AU - Harris, M H

AU - Lund-Aho, T

AU - Juvonen, V

AU - Heidenreich, O

AU - Vormoor, J

AU - Choi, W W L

AU - Jarosova, M

AU - Kolenova, A

AU - Bueno, C

AU - Menendez, P

AU - Wehner, S

AU - Eckert, C

AU - Talmant, P

AU - Tondeur, S

AU - Lippert, E

AU - Launay, E

AU - Henry, C

AU - Ballerini, P

AU - Lapillone, H

AU - Callanan, M B

AU - Cayuela, J M

AU - Herbaux, C

AU - Cazzaniga, G

AU - Kakadiya, P M

AU - Bohlander, S

AU - Ahlmann, M

AU - Choi, J R

AU - Gameiro, P

AU - Lee, D S

AU - Krauter, J

AU - Cornillet-Lefebvre, P

AU - Te Kronnie, G

AU - Schäfer, B W

AU - Kubetzko, S

AU - Alonso, C N

AU - zur Stadt, U

AU - Sutton, R

AU - Venn, N C

AU - Izraeli, S

AU - Trakhtenbrot, L

AU - Madsen, H O

AU - Archer, P

AU - Hancock, J

AU - Cerveira, N

AU - Teixeira, M R

AU - Lo Nigro, L

AU - Möricke, A

AU - Stanulla, M

AU - Schrappe, M

AU - Sedék, L

AU - Szczepański, T

AU - Zwaan, C M

AU - Coenen, E A

AU - van den Heuvel-Eibrink, M M

AU - Strehl, S

AU - Dworzak, M

AU - Panzer-Grümayer, R

AU - Dingermann, T

AU - Klingebiel, T

AU - Marschalek, R

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the MLL gene (≈ 90%): AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, ELL, partial tandem duplications (MLL PTDs) and MLLT4/AF6, respectively. The MLL breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal MLL fusions deriving from complex rearrangements.

AB - Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the MLL gene (≈ 90%): AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, ELL, partial tandem duplications (MLL PTDs) and MLLT4/AF6, respectively. The MLL breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal MLL fusions deriving from complex rearrangements.

KW - Acute Disease

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Animals

KW - Child

KW - Child, Preschool

KW - Chromosome Breakage

KW - Female

KW - Gene Rearrangement

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Leukemia

KW - Male

KW - Mice

KW - Middle Aged

KW - Myeloid-Lymphoid Leukemia Protein

KW - Oncogene Proteins, Fusion

KW - Polymerase Chain Reaction

KW - Prognosis

KW - Translocation, Genetic

KW - Young Adult

U2 - 10.1038/leu.2013.135

DO - 10.1038/leu.2013.135

M3 - SCORING: Journal article

C2 - 23628958

VL - 27

SP - 2165

EP - 2176

JO - LEUKEMIA

JF - LEUKEMIA

SN - 0887-6924

IS - 11

ER -