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The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis

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The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis. / Lombino, Franco L; Muhia, Mary; Lopez-Rojas, Jeffrey; Brill, Monika S; Thies, Edda; Ruschkies, Laura; Lutz, David; Richter, Melanie; Hausrat, Torben J; Lopes, André T; McNally, Francis J; Hermans-Borgmeyer, Irm; Dunleavy, Jessica E M; Hoffmeister-Ullerich, Sabine; Frotscher, Michael; Misgeld, Thomas; Kreutz, Michael R; de Anda, Froylan Calderon; Kneussel, Matthias.

In: SCI REP-UK, Vol. 9, No. 1, 04.11.2019, p. 15940.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lombino, FL, Muhia, M, Lopez-Rojas, J, Brill, MS, Thies, E, Ruschkies, L, Lutz, D, Richter, M, Hausrat, TJ, Lopes, AT, McNally, FJ, Hermans-Borgmeyer, I, Dunleavy, JEM, Hoffmeister-Ullerich, S, Frotscher, M, Misgeld, T, Kreutz, MR, de Anda, FC & Kneussel, M 2019, 'The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis', SCI REP-UK, vol. 9, no. 1, pp. 15940. https://doi.org/10.1038/s41598-019-52367-3

APA

Lombino, F. L., Muhia, M., Lopez-Rojas, J., Brill, M. S., Thies, E., Ruschkies, L., Lutz, D., Richter, M., Hausrat, T. J., Lopes, A. T., McNally, F. J., Hermans-Borgmeyer, I., Dunleavy, J. E. M., Hoffmeister-Ullerich, S., Frotscher, M., Misgeld, T., Kreutz, M. R., de Anda, F. C., & Kneussel, M. (2019). The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis. SCI REP-UK, 9(1), 15940. https://doi.org/10.1038/s41598-019-52367-3

Vancouver

Lombino FL, Muhia M, Lopez-Rojas J, Brill MS, Thies E, Ruschkies L et al. The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis. SCI REP-UK. 2019 Nov 4;9(1):15940. https://doi.org/10.1038/s41598-019-52367-3

Bibtex

@article{664b1cbfcc0f49b787be70cbee58b0a3,
title = "The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis",
abstract = "Microtubule severing regulates cytoskeletal rearrangement underlying various cellular functions. Katanin, a heterodimer, consisting of catalytic (p60) and regulatory (p80) subunits severs dynamic microtubules to modulate several stages of cell division. The role of p60 katanin in the mammalian brain with respect to embryonic and adult neurogenesis is poorly understood. Here, we generated a Katna1 knockout mouse and found that consistent with a critical role of katanin in mitosis, constitutive homozygous Katna1 depletion is lethal. Katanin p60 haploinsufficiency induced an accumulation of neuronal progenitors in the subventricular zone during corticogenesis, and impaired their proliferation in the adult hippocampus dentate gyrus (DG) subgranular zone. This did not compromise DG plasticity or spatial and contextual learning and memory tasks employed in our study, consistent with the interpretation that adult neurogenesis may be associated with selective forms of hippocampal-dependent cognitive processes. Our data identify a critical role for the microtubule-severing protein katanin p60 in regulating neuronal progenitor proliferation in vivo during embryonic development and adult neurogenesis.",
author = "Lombino, {Franco L} and Mary Muhia and Jeffrey Lopez-Rojas and Brill, {Monika S} and Edda Thies and Laura Ruschkies and David Lutz and Melanie Richter and Hausrat, {Torben J} and Lopes, {Andr{\'e} T} and McNally, {Francis J} and Irm Hermans-Borgmeyer and Dunleavy, {Jessica E M} and Sabine Hoffmeister-Ullerich and Michael Frotscher and Thomas Misgeld and Kreutz, {Michael R} and {de Anda}, {Froylan Calderon} and Matthias Kneussel",
year = "2019",
month = nov,
day = "4",
doi = "10.1038/s41598-019-52367-3",
language = "English",
volume = "9",
pages = "15940",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis

AU - Lombino, Franco L

AU - Muhia, Mary

AU - Lopez-Rojas, Jeffrey

AU - Brill, Monika S

AU - Thies, Edda

AU - Ruschkies, Laura

AU - Lutz, David

AU - Richter, Melanie

AU - Hausrat, Torben J

AU - Lopes, André T

AU - McNally, Francis J

AU - Hermans-Borgmeyer, Irm

AU - Dunleavy, Jessica E M

AU - Hoffmeister-Ullerich, Sabine

AU - Frotscher, Michael

AU - Misgeld, Thomas

AU - Kreutz, Michael R

AU - de Anda, Froylan Calderon

AU - Kneussel, Matthias

PY - 2019/11/4

Y1 - 2019/11/4

N2 - Microtubule severing regulates cytoskeletal rearrangement underlying various cellular functions. Katanin, a heterodimer, consisting of catalytic (p60) and regulatory (p80) subunits severs dynamic microtubules to modulate several stages of cell division. The role of p60 katanin in the mammalian brain with respect to embryonic and adult neurogenesis is poorly understood. Here, we generated a Katna1 knockout mouse and found that consistent with a critical role of katanin in mitosis, constitutive homozygous Katna1 depletion is lethal. Katanin p60 haploinsufficiency induced an accumulation of neuronal progenitors in the subventricular zone during corticogenesis, and impaired their proliferation in the adult hippocampus dentate gyrus (DG) subgranular zone. This did not compromise DG plasticity or spatial and contextual learning and memory tasks employed in our study, consistent with the interpretation that adult neurogenesis may be associated with selective forms of hippocampal-dependent cognitive processes. Our data identify a critical role for the microtubule-severing protein katanin p60 in regulating neuronal progenitor proliferation in vivo during embryonic development and adult neurogenesis.

AB - Microtubule severing regulates cytoskeletal rearrangement underlying various cellular functions. Katanin, a heterodimer, consisting of catalytic (p60) and regulatory (p80) subunits severs dynamic microtubules to modulate several stages of cell division. The role of p60 katanin in the mammalian brain with respect to embryonic and adult neurogenesis is poorly understood. Here, we generated a Katna1 knockout mouse and found that consistent with a critical role of katanin in mitosis, constitutive homozygous Katna1 depletion is lethal. Katanin p60 haploinsufficiency induced an accumulation of neuronal progenitors in the subventricular zone during corticogenesis, and impaired their proliferation in the adult hippocampus dentate gyrus (DG) subgranular zone. This did not compromise DG plasticity or spatial and contextual learning and memory tasks employed in our study, consistent with the interpretation that adult neurogenesis may be associated with selective forms of hippocampal-dependent cognitive processes. Our data identify a critical role for the microtubule-severing protein katanin p60 in regulating neuronal progenitor proliferation in vivo during embryonic development and adult neurogenesis.

U2 - 10.1038/s41598-019-52367-3

DO - 10.1038/s41598-019-52367-3

M3 - SCORING: Journal article

C2 - 31685876

VL - 9

SP - 15940

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -