The microenvironment in the human lung partly determines the site of the first metastasis

Merve Yanar; Florian Abel; Thomas Haalck; Susanne Klutmann; Udo Schumacher

The microenvironment in the human lung partly determines the site of the first metastasis

Standard

The microenvironment in the human lung partly determines the site of the first metastasis. / Yanar, Merve; Abel, Florian; Haalck, Thomas ; Klutmann, Susanne ; Schumacher, Udo.

In: ANTICANCER RES, Vol. 34, No. 7, 01.07.2014, p. 3845-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Yanar, M, Abel, F, Haalck, T , Klutmann, S & Schumacher, U 2014, 'The microenvironment in the human lung partly determines the site of the first metastasis', ANTICANCER RES, vol. 34, no. 7, pp. 3845-9.

APA

Yanar, M., Abel, F., Haalck, T., Klutmann, S., & Schumacher, U. (2014). The microenvironment in the human lung partly determines the site of the first metastasis. ANTICANCER RES, 34(7), 3845-9.

Vancouver

Yanar M, Abel F, Haalck T , Klutmann S , Schumacher U. The microenvironment in the human lung partly determines the site of the first metastasis. ANTICANCER RES. 2014 Jul 1;34(7):3845-9.

Bibtex

@article{57064e9753f5488887c399cafe80bac8,

title = "The microenvironment in the human lung partly determines the site of the first metastasis",

abstract = "BACKGROUND: Due to local ventilation and perfusion differences in the pulmonary lobes, the microenvironmental influence on metastasis formation in the lung can be studied. We, therefore, investigated whether the anatomical distribution of first lung metastases follow a particular pattern.MATERIALS AND METHODS: Thirty-three out of 273 patients with melanoma who underwent 18F-fluorodeoxyglucose positron emission tomography and computed tomography (18FDG-PET/CT) were identified as patients with detected primary pulmonary metastases. All solitary metastases were allocated to the appropriate lung segment.RESULTS: Segment L3 had the significantly highest number of metastases (n=11; p<0.001). Overall, both upper lung lobes manifested numerously more metastases in comparison to the lower lobes (26 metastases (70%) vs. 11 metastases (30%); p<0.001).CONCLUSION: Our results provide novel information supporting the hypothesis that pulmonary metastases occur prevalently in the upper lung segments.",

keywords = "Adult, Aged, Aged, 80 and over, Female, Fluorodeoxyglucose F18, Humans, Lung, Lung Neoplasms, Male, Melanoma, Middle Aged, Multimodal Imaging, Positron-Emission Tomography, Radiopharmaceuticals, Tomography, X-Ray Computed, Tumor Microenvironment",

author = "Merve Yanar and Florian Abel and Thomas Haalck and Susanne Klutmann and Udo Schumacher",

year = "2014",

month = jul,

day = "1",

language = "English",

volume = "34",

pages = "3845--9",

journal = "ANTICANCER RES",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "7",

}

RIS

TY - JOUR

T1 - The microenvironment in the human lung partly determines the site of the first metastasis

AU - Yanar, Merve

AU - Abel, Florian

AU - Haalck, Thomas

AU - Klutmann, Susanne

AU - Schumacher, Udo

PY - 2014/7/1

Y1 - 2014/7/1

N2 - BACKGROUND: Due to local ventilation and perfusion differences in the pulmonary lobes, the microenvironmental influence on metastasis formation in the lung can be studied. We, therefore, investigated whether the anatomical distribution of first lung metastases follow a particular pattern.MATERIALS AND METHODS: Thirty-three out of 273 patients with melanoma who underwent 18F-fluorodeoxyglucose positron emission tomography and computed tomography (18FDG-PET/CT) were identified as patients with detected primary pulmonary metastases. All solitary metastases were allocated to the appropriate lung segment.RESULTS: Segment L3 had the significantly highest number of metastases (n=11; p<0.001). Overall, both upper lung lobes manifested numerously more metastases in comparison to the lower lobes (26 metastases (70%) vs. 11 metastases (30%); p<0.001).CONCLUSION: Our results provide novel information supporting the hypothesis that pulmonary metastases occur prevalently in the upper lung segments.

AB - BACKGROUND: Due to local ventilation and perfusion differences in the pulmonary lobes, the microenvironmental influence on metastasis formation in the lung can be studied. We, therefore, investigated whether the anatomical distribution of first lung metastases follow a particular pattern.MATERIALS AND METHODS: Thirty-three out of 273 patients with melanoma who underwent 18F-fluorodeoxyglucose positron emission tomography and computed tomography (18FDG-PET/CT) were identified as patients with detected primary pulmonary metastases. All solitary metastases were allocated to the appropriate lung segment.RESULTS: Segment L3 had the significantly highest number of metastases (n=11; p<0.001). Overall, both upper lung lobes manifested numerously more metastases in comparison to the lower lobes (26 metastases (70%) vs. 11 metastases (30%); p<0.001).CONCLUSION: Our results provide novel information supporting the hypothesis that pulmonary metastases occur prevalently in the upper lung segments.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Lung

KW - Lung Neoplasms

KW - Male

KW - Melanoma

KW - Middle Aged

KW - Multimodal Imaging

KW - Positron-Emission Tomography

KW - Radiopharmaceuticals

KW - Tomography, X-Ray Computed

KW - Tumor Microenvironment

M3 - SCORING: Journal article

C2 - 24982412

VL - 34

SP - 3845

EP - 3849

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 7

ER -